Tailoring biomaterials for vaccine delivery

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 12, 2024

Biomaterials are substances that can be injected, implanted, or applied to the surface of tissues in biomedical applications and have ability interact with biological systems initiate therapeutic responses. Biomaterial-based vaccine delivery possess robust packaging capabilities, enabling sustained localized drug release at target site. Throughout process, they contribute protecting, stabilizing, guiding immunogen while also serving as adjuvants enhance efficacy. In this article, we provide a comprehensive review contributions biomaterials advancement development. We begin by categorizing biomaterial types properties, detailing their reprocessing strategies, exploring several common systems, such polymeric nanoparticles, lipid hydrogels, microneedles. Additionally, investigated how physicochemical properties routes influence immune Notably, delve into design considerations adjuvants, showcasing application development for cancer, acquired immunodeficiency syndrome, influenza, corona virus disease 2019 (COVID-19), tuberculosis, malaria, hepatitis B. review, highlight successful instances where enhanced efficacy discuss limitations future directions immunotherapy. This aims offer researchers understanding stimulate further progress related fields.

Язык: Английский

---

Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2641 - 2641

Опубликована: Ноя. 20, 2023

Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition architecture can vary over a wide range. Their unique ability to form secondary structures, as well different pathways of modification biofunctionalization due the diversity amino acids, provide variation in physicochemical biological properties polypeptide-containing materials. In this review article, we summarize advances synthesis their copolymers application these systems for drug delivery (nano)particles or hydrogels. The issues, such (nano)particle types, methods preparation loading, influence characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, immunogenicity nanoparticles formulations, comprehensively discussed. Finally, recent development certain nanoformulations peptides, proteins, gene delivery, cancer therapy, antimicrobial anti-inflammatory summarized.

Язык: Английский

---

A biocompatible, thin, wet-adhesive, and high-performance zinc-ion hybrid supercapacitor as an implantable power source for biomedical application

Nano Energy, Год журнала: 2024, Номер 132, С. 110345 - 110345

Опубликована: Окт. 10, 2024

Язык: Английский

---

Localized, on-demand, sustained drug delivery from biopolymer-based materials

Expert Opinion on Drug Delivery, Год журнала: 2022, Номер 19(10), С. 1317 - 1335

Опубликована: Авг. 5, 2022

Local drug delivery facilitiates higher concentrations of molecules at or near the treatment site to enhance efficiency and reduce toxicity other systemic side effects. However, local systems face challenges in terms encapsulation, delivery, controlled release therapeutics.We provide an overview naturally derived biopolymer-based for localized, sustained, on-demand treatment. We introduce advantages limitations these release, as well recent applications.Naturally biopolymers like cellulose, silk fibroin, chitosan, alginate, hyaluronic acid, gelatin are good candidates localized because they readily chemically modified, biocompatible, biodegradable (with generation metabolically compatible degradation products), can be processed aqueous ambient environments maintain bioactivity various therapeutics. The tradeoff between effective dosage response by healthy tissue should balanced during design systems. Future directions will focused on strategies tunable biodegradation rates, explore commercial utility substituting currently utilized synthetic polymers implants delivery.

Язык: Английский

---

Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Chinese Chemical Letters, Год журнала: 2023, Номер 35(7), С. 109169 - 109169

Опубликована: Окт. 9, 2023

Язык: Английский

---