Expert Opinion on Drug Delivery,
Год журнала:
2022,
Номер
19(10), С. 1317 - 1335
Опубликована: Авг. 5, 2022
Local
drug
delivery
facilitiates
higher
concentrations
of
molecules
at
or
near
the
treatment
site
to
enhance
efficiency
and
reduce
toxicity
other
systemic
side
effects.
However,
local
systems
face
challenges
in
terms
encapsulation,
delivery,
controlled
release
therapeutics.We
provide
an
overview
naturally
derived
biopolymer-based
for
localized,
sustained,
on-demand
treatment.
We
introduce
advantages
limitations
these
release,
as
well
recent
applications.Naturally
biopolymers
like
cellulose,
silk
fibroin,
chitosan,
alginate,
hyaluronic
acid,
gelatin
are
good
candidates
localized
because
they
readily
chemically
modified,
biocompatible,
biodegradable
(with
generation
metabolically
compatible
degradation
products),
can
be
processed
aqueous
ambient
environments
maintain
bioactivity
various
therapeutics.
The
tradeoff
between
effective
dosage
response
by
healthy
tissue
should
balanced
during
design
systems.
Future
directions
will
focused
on
strategies
tunable
biodegradation
rates,
explore
commercial
utility
substituting
currently
utilized
synthetic
polymers
implants
delivery.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 12, 2024
Biomaterials
are
substances
that
can
be
injected,
implanted,
or
applied
to
the
surface
of
tissues
in
biomedical
applications
and
have
ability
interact
with
biological
systems
initiate
therapeutic
responses.
Biomaterial-based
vaccine
delivery
possess
robust
packaging
capabilities,
enabling
sustained
localized
drug
release
at
target
site.
Throughout
process,
they
contribute
protecting,
stabilizing,
guiding
immunogen
while
also
serving
as
adjuvants
enhance
efficacy.
In
this
article,
we
provide
a
comprehensive
review
contributions
biomaterials
advancement
development.
We
begin
by
categorizing
biomaterial
types
properties,
detailing
their
reprocessing
strategies,
exploring
several
common
systems,
such
polymeric
nanoparticles,
lipid
hydrogels,
microneedles.
Additionally,
investigated
how
physicochemical
properties
routes
influence
immune
Notably,
delve
into
design
considerations
adjuvants,
showcasing
application
development
for
cancer,
acquired
immunodeficiency
syndrome,
influenza,
corona
virus
disease
2019
(COVID-19),
tuberculosis,
malaria,
hepatitis
B.
review,
highlight
successful
instances
where
enhanced
efficacy
discuss
limitations
future
directions
immunotherapy.
This
aims
offer
researchers
understanding
stimulate
further
progress
related
fields.
Pharmaceutics,
Год журнала:
2023,
Номер
15(11), С. 2641 - 2641
Опубликована: Ноя. 20, 2023
Synthetic
polypeptides
are
biocompatible
and
biodegradable
macromolecules
whose
composition
architecture
can
vary
over
a
wide
range.
Their
unique
ability
to
form
secondary
structures,
as
well
different
pathways
of
modification
biofunctionalization
due
the
diversity
amino
acids,
provide
variation
in
physicochemical
biological
properties
polypeptide-containing
materials.
In
this
review
article,
we
summarize
advances
synthesis
their
copolymers
application
these
systems
for
drug
delivery
(nano)particles
or
hydrogels.
The
issues,
such
(nano)particle
types,
methods
preparation
loading,
influence
characteristics
on
stability,
degradability,
cellular
uptake,
cytotoxicity,
hemolysis,
immunogenicity
nanoparticles
formulations,
comprehensively
discussed.
Finally,
recent
development
certain
nanoformulations
peptides,
proteins,
gene
delivery,
cancer
therapy,
antimicrobial
anti-inflammatory
summarized.
Expert Opinion on Drug Delivery,
Год журнала:
2022,
Номер
19(10), С. 1317 - 1335
Опубликована: Авг. 5, 2022
Local
drug
delivery
facilitiates
higher
concentrations
of
molecules
at
or
near
the
treatment
site
to
enhance
efficiency
and
reduce
toxicity
other
systemic
side
effects.
However,
local
systems
face
challenges
in
terms
encapsulation,
delivery,
controlled
release
therapeutics.We
provide
an
overview
naturally
derived
biopolymer-based
for
localized,
sustained,
on-demand
treatment.
We
introduce
advantages
limitations
these
release,
as
well
recent
applications.Naturally
biopolymers
like
cellulose,
silk
fibroin,
chitosan,
alginate,
hyaluronic
acid,
gelatin
are
good
candidates
localized
because
they
readily
chemically
modified,
biocompatible,
biodegradable
(with
generation
metabolically
compatible
degradation
products),
can
be
processed
aqueous
ambient
environments
maintain
bioactivity
various
therapeutics.
The
tradeoff
between
effective
dosage
response
by
healthy
tissue
should
balanced
during
design
systems.
Future
directions
will
focused
on
strategies
tunable
biodegradation
rates,
explore
commercial
utility
substituting
currently
utilized
synthetic
polymers
implants
delivery.
