Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Regenerative Biomaterials, Год журнала: 2022, Номер 10

Опубликована: Дек. 8, 2022

Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary diseases. Direct drug delivery to the lungs allows one obtain high concentration in site action with limited systemic distribution, leading a more effective therapy reduced required doses and side effects. On other hand, there are several difficulties obtaining formulation that would meet all criteria related physicochemical, aerodynamic biological properties, which is reason why only very few investigated systems can reach clinical trial phase proceed everyday use as result. Therefore, we focused on powders consisting polysaccharides, lipids, proteins or natural synthetic polymers form microparticles delivered by inhalation carriers. We summarized most common trends research today provide best dry right fraction for be able release before being removed mechanisms. This review article addresses manufacturing methods novel modifications, pros cons different materials, loading capacities profiles, properties such cytocompatibility, bactericidal anticancer properties.

Язык: Английский

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Localized, on-demand, sustained drug delivery from biopolymer-based materials

Expert Opinion on Drug Delivery, Год журнала: 2022, Номер 19(10), С. 1317 - 1335

Опубликована: Авг. 5, 2022

Local drug delivery facilitiates higher concentrations of molecules at or near the treatment site to enhance efficiency and reduce toxicity other systemic side effects. However, local systems face challenges in terms encapsulation, delivery, controlled release therapeutics.We provide an overview naturally derived biopolymer-based for localized, sustained, on-demand treatment. We introduce advantages limitations these release, as well recent applications.Naturally biopolymers like cellulose, silk fibroin, chitosan, alginate, hyaluronic acid, gelatin are good candidates localized because they readily chemically modified, biocompatible, biodegradable (with generation metabolically compatible degradation products), can be processed aqueous ambient environments maintain bioactivity various therapeutics. The tradeoff between effective dosage response by healthy tissue should balanced during design systems. Future directions will focused on strategies tunable biodegradation rates, explore commercial utility substituting currently utilized synthetic polymers implants delivery.

Язык: Английский

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Polypeptide-Based Systems: From Synthesis to Application in Drug Delivery

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2641 - 2641

Опубликована: Ноя. 20, 2023

Synthetic polypeptides are biocompatible and biodegradable macromolecules whose composition architecture can vary over a wide range. Their unique ability to form secondary structures, as well different pathways of modification biofunctionalization due the diversity amino acids, provide variation in physicochemical biological properties polypeptide-containing materials. In this review article, we summarize advances synthesis their copolymers application these systems for drug delivery (nano)particles or hydrogels. The issues, such (nano)particle types, methods preparation loading, influence characteristics on stability, degradability, cellular uptake, cytotoxicity, hemolysis, immunogenicity nanoparticles formulations, comprehensively discussed. Finally, recent development certain nanoformulations peptides, proteins, gene delivery, cancer therapy, antimicrobial anti-inflammatory summarized.

Язык: Английский

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A biocompatible, thin, wet-adhesive, and high-performance zinc-ion hybrid supercapacitor as an implantable power source for biomedical application

Nano Energy, Год журнала: 2024, Номер 132, С. 110345 - 110345

Опубликована: Окт. 10, 2024

Язык: Английский

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Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Chinese Chemical Letters, Год журнала: 2023, Номер 35(7), С. 109169 - 109169

Опубликована: Окт. 9, 2023

Язык: Английский

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