Materials,
Год журнала:
2022,
Номер
15(14), С. 4823 - 4823
Опубликована: Июль 11, 2022
The
aim
of
this
study
is
to
prepare
ciprofloxacin
(CIP)
or
levofloxacin
(LEVO)-incorporated
and
polydopamine
(PDA)-coated
nephrite
composites
for
application
in
drug-eluting
contact
lenses.
PDA
was
coated
onto
the
surface
improve
antibacterial
activity
payload
antibiotics.
CIP
LEVO
incorporated
into
layer
on
nephrite.
Furthermore,
CIP-incorporated/PDA-coated
were
embedded
PDA-coated
showed
dull
smooth
surfaces
according
dopamine
concentration
while
itself
has
sharp
morphology.
CIP-
LEVO-loaded/PDA-coated
also
have
properties.
Nano
and/or
sub-micron
clusters
observed
field
emission-scanning
electron
microscopy
(FE-SEM)
observation,
indicating
that
nanoparticles
accumulated
LEVO-incorporated/PDA-coated
sustained
release
vitro
these
properties
contributed
enhanced
compared
composites.
lenses
then,
an
study,
they
higher
bactericidal
effect
against
Staphylococcus
aureus
(S.
aureus)
We
suggest
composite-embedded
are
a
promising
candidate
therapeutic
application.
Advanced Materials,
Год журнала:
2023,
Номер
36(11)
Опубликована: Ноя. 10, 2023
Inkjet
printing
(IJP)
is
an
additive
manufacturing
process
that
selectively
deposits
ink
materials,
layer-by-layer,
to
create
3D
objects
or
2D
patterns
with
precise
control
over
their
structure
and
composition.
This
technology
has
emerged
as
attractive
versatile
approach
address
the
ever-evolving
demands
of
personalized
medicine
in
healthcare
industry.
Although
originally
developed
for
nonhealthcare
applications,
IJP
harnesses
potential
pharma-inks,
which
are
meticulously
formulated
inks
containing
drugs
pharmaceutical
excipients.
Delving
into
formulation
components
key
adaptable
material
deposition
enabled
by
unraveled.
The
review
extends
its
focus
substrate
including
paper,
films,
foams,
lenses,
3D-printed
showcasing
diverse
advantages,
while
exploring
a
wide
spectrum
therapeutic
applications.
Additionally,
benefits
hardware
software
improvements,
along
artificial
intelligence
integration,
discussed
enhance
IJP's
precision
efficiency.
Embracing
these
advancements,
holds
immense
reshape
traditional
processes,
ushering
era
medical
precision.
However,
further
exploration
optimization
needed
fully
utilize
capabilities.
As
researchers
push
boundaries
IJP,
vision
patient-specific
treatment
on
horizon
becoming
tangible
reality.
The
deployment
of
structures
that
enable
localized
release
bioactive
molecules
can
result
in
more
efficacious
treatment
disease
and
better
integration
implantable
bionic
devices.
strategic
design
a
biopolymeric
coating
be
used
to
engineer
the
optimal
profile
depending
on
task
at
hand.
As
illustrative
examples,
here
advances
delivery
drugs
from
bone,
brain,
ocular,
cardiovascular
implants
are
reviewed.
These
areas
focused
highlight
both
hard
soft
tissue
benefit
controlled
delivery.
composition
biopolymers
achieve
appropriate
selected
types,
their
corresponding
outcomes
brought
fore.
To
conclude,
key
factors
designing
drug-loaded
coatings
for
biomedical
highlighted.
Biomacromolecules,
Год журнала:
2023,
Номер
24(4), С. 1648 - 1661
Опубликована: Март 8, 2023
The
use
of
polydopamine-based
bioinspired
nanomaterials
has
shed
new
light
on
advanced
drug
delivery
arising
from
their
efficient
surface
functionalization.
More
recently,
the
polydopamine
self-assemblies
formed
in
two
different
modalities,
i.e.,
nonporous
and
mesoporous
nanoparticles,
have
begun
to
attract
attention
due
expedient
versatile
properties.
However,
possibility
for
dermal
local
therapy,
as
well
interaction
with
skin,
not
yet
been
demonstrated.
Our
study
aimed
compare
explore
feasibility
self-assembled
nanoparticles
(PDA)
(mPDA)
skin
delivery.
formation
PDA
mPDA
structures
was
confirmed
by
UV–vis–NIR
absorption
spectrum,
Fourier
transform
infrared
spectroscopy,
nitrogen
adsorption/desorption
isotherms.
Using
retinoic
acid
(RA)
model
drug,
effects
loading,
release,
photostability,
penetration,
radical
scavenging
were
investigated.
Laser
scanning
confocal
microscopy
(LSCM)
hematoxylin
eosin
(H&E)
introduced
probe
routes
possible
skin.
results
indicated
that
both
could
reduce
photodegradation
RA,
showed
significantly
better
activity
loading
capacity.
ex
vivo
permeation
revealed
enhanced
RA
into
deep
layers
comparison
solution,
which
follicular
intercellular
pathways
existed,
alteration
structure
stratum
corneum
observed.
In
capacity,
size
controllability,
physical
stability,
activity,
more
preferable
improvement
these
factors.
This
work
demonstrated
promising
application
delivery,
comparative
concept
types
biomaterials
can
provide
implications
other
fields.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(50), С. 55431 - 55446
Опубликована: Дек. 10, 2022
Design
of
advanced
contact
lenses
(CLs)
demands
materials
that
are
safe
and
comfortable
for
the
wearers
preserve
normal
eye
microbiota,
avoiding
chronic
inflammation
biofilm
development.
This
work
aimed
to
combine
natural
antibiofouling
phosphorylcholine
antioxidant
prebiotic
resveratrol
as
integral
components
CLs
may
have
additional
performance
preventing
oxidative-stress
related
diseases.
Different
from
previous
uses
2-methacryloyloxyethyl
(MPC)
coating,
we
explored
feasibility
adding
MPC
at
high
proportions
a
comonomer
2-hydroxyethyl
methacrylate
(HEMA)-based
hydrogels
while
still
allowing
loading
hydrophobic
resveratrol.
Homogeneous
distribution
along
hydrogel
depth
(confirmed
by
Raman
spectroscopy)
notably
increased
solvent
uptake
proportion
free
water
it
decreased
Young's
modulus.
Relevantly,
did
not
hinder
(>10
mg/g),
which
indeed
showed
network/water
partition
coefficients
>100.
Protocols
sterilization
under
aseptic
conditions
were
implemented,
effects
tear
proteins
on
release
rate
investigated.
sustained
more
than
24
h
in
vitro,
sorption
albumin
onto
hydrogel,
although
attenuated
MPC,
slowed
down
release.
The
combination
reduced
P.
aeruginosa
S.
aureus
growth
tested
novel
disk-agar
interface
setup.
developed
excellent
anti-inflammatory
properties
biocompatibility
ovo
rabbit
tests
provided
higher
prolonged
levels
fluid,
favored
biodistribution
anterior
posterior
segments
compared
drops.
Correlations
between
profiles
vitro
vivo
assessed.
preserved
during
entire
8
wearing.
In
sum,
prepared
with
help
address
safety
comfort
requirements
having
drug
releasing
capabilities.
