Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 158, С. 114146 - 114146

Опубликована: Дек. 28, 2022

Lung cancer is the most common cause of mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed past decades, but prognosis lung still poor. In this study, we developed cisplatin (CDDP)-loaded human serum albumin (HSA)-based gold nanoshells (HCP@GNSs) for synergistic chemo-photothermal therapy (chemo-PTT). HCP@GNSs not only acted as drug nanocarriers chemotherapy also serve a superior mediator PTT, which could exhibit temperature increase upon near infrared (NIR) laser exposure that was sufficient photothermal ablation. were highly biocompatible hemocompatible nanocarriers, while chemo-PTT resulting from plus NIR displayed stronger cytotoxicity effect than or PTT alone, especially at low CDDP concentration. vivo analysis demonstrated HCP@GNSs-mediated increased necrosis tumors to achieve high tumor clearance rate with no adverse side effects. Moreover, HCP@GNSs-medicated induced recruitment dendritic cells, B-cells, natural killer T-cells distal inhibit growth tumors. Therefore, CDDP-loaded may be potential nanomedicine candidate curative treatment future.

Язык: Английский

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Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications

Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2574 - 2574

Опубликована: Ноя. 2, 2023

The widespread application of calcium carbonate is determined by its high availability in nature and simplicity synthesis laboratory conditions. Moreover, possesses highly attractive physicochemical properties that make it suitable for a wide range biomedical applications. This review provides conclusive analysis the results on using tunable vaterite metastability development biodegradable drug delivery systems therapeutic vehicles with controlled sustained release incorporated cargo. manuscript highlights nuances recrystallization to non-porous calcite, dissolution at acidic pH, biodegradation vivo conditions control over these processes. outlines main benefits instability liberation encapsulated molecules natural synthetic polymeric materials purposes.

Язык: Английский

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Radiosensitizer-based injectable hydrogel for enhanced radio-chemotherapy of TNBC

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Год журнала: 2024, Номер 52(7), С. 100414 - 100414

Опубликована: Июнь 27, 2024

Radionuclide therapy (RNT) stands out as a highly effective method for treating solid tumors. However, its therapeutic efficiency faces challenges due to the radioresistance of tumors, limited penetration depth and intracellular deposition rays in tumor tissue, which causes residue living cancer cells. Herein, we report novel approach by utilizing radionuclide 131I-labelled polydopamine encapsulated gold nanoparticle co-loaded with classical anticancer drug gemcitabine within hydrogel formed from oxidized glucan chitosan hydrochloride, combining RNT chemotherapy treatment. Au, high Z element, is able interact short-range β-rays emit bremsstrahlung secondary charged particles turn increase dose deposited Simultaneously, affect cell cycle redistribution, resulting an radiosensitive cellular component cycle, also inhibits repair radioactive damage DNA, has radiosensitizing effect. In both vivo vitro experiments, injectable demonstrates excellent biosecurity, stability labeling, capabilities single-photon emission computed tomography (SPECT) imaging. Compared analysis single revealed that combination markedly growth triple-negative breast cancer. This integrated strategy establishes efficient synergistic treatment platform, offering new avenues advancing clinical

Язык: Английский

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Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations monotherapy augment therapeutic efficacy. However, it remains a challenge design single delivery vehicle that can incorporate chemotherapeutics radionuclides into compact structure. Here, chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble nanoparticles due its inherent amphiphilicity. then be effectively labeled with lutetium-177 (177Lu) diagnostic gallium-68 (68Ga)/copper-64 (64Cu) high radiolabeling efficiency radiochemical stability. Impressively, single-dose chemoradiation [177Lu]Lu-DOTA-EB-CPT plus EB-CPT inhibited tumor growth in HCT116 tumor-bearing mice compared respective individual approach. [64Cu]Cu-NOTA-EB-CPT also exhibited excellent vivo characteristics including favorable blood circulation properties prolonged retention mice. safety, feasibility, tolerability, biodistribution [68Ga]Ga-NOTA-EB-ss-CPT were preliminarily characterized first-in-human study. This study presents simple but robust radiopharmaceutical leverages EB as an albumin binder strike delicate balance between enhanced accumulation, efficacy, facilitating integrated theranostic strategy within molecular radionuclide-labeled nanomedicine step toward clinical translation radiotheranostics.

Язык: Английский

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Assessment of Phytochemical Profile, Antioxidant, and Anticancer Activity Against Colon Cancer-HT-29: A Potent Therapeutic Medicinal Plant (Tarenna alpestris) in Megamalai Hills, Western Ghats, India

Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Язык: Английский

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Ultrasound-actuated Ion Homeostasis Perturbator for Oxidative Damage-augmented Ca2+ Interference Therapy and Combined Immunotherapy

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101666 - 101666

Опубликована: Март 1, 2025

Calcium ion therapy has shown promise for cancer treatment, but its efficacy is limited by the cellular calcium buffering mechanism. Herein, an homeostasis disruptor (PCCa) was synthesized using in situ mineralization method. The surface of porphyrin-metal-organic framework PCN coated with carbonate (CaCO3), aimed at causing Ca2+ overload and disrupting self-defense mechanism during imbalance. Upon internalization into tumor cells, PCCa undergoes lysosomal acidification-induced CaCO3 decomposition, leading to instantaneous overload. Simultaneously, under ultrasonic irradiation, meso-tetra-(4-carboxyphenyl)porphine (TCPP) within generates reactive oxygen species (ROS), which impairs capacity amplifies cell damage caused In addition, could also induce immunogenic death, release tumor-associated antigens (TAA), act as adjuvant, thereby promoting dendritic maturation enhancing antitumor activity CD8+ T cells. mouse models, not only led significant regression subcutaneous mammary tumors demonstrated substantial anti-metastatic effects. summary, proposed ultrasound-actuated interference strategy promising deactivate maintenance system, contributing attainment splendid treatment outcome reliable biosafety, may provide useful insights therapy.

Язык: Английский

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Synthesis, characterisation and imaging potential of holmium-166 loaded calcium carbonate nanoparticles for targeted internal radiation therapy of colorectal cancer

Health and Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Язык: Английский

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Harnessing the Power of Nanocarriers to Exploit the Tumor Microenvironment for Enhanced Cancer Therapy

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 746 - 746

Опубликована: Май 19, 2025

The tumor microenvironment (TME) has a major role in malignancy and its complex nature can mediate survival, metastasis, immune evasion, drug resistance. Thus, reprogramming or regulating the immunosuppressive TME significant contribution to make cancer therapy. Targeting with nanocarriers (NCs) been widely used directly deliver anticancer drugs control TME, which revealed auspicious outcomes. be reprogrammed by using range of NCs regulate factors activate immunostimulatory cells. Moreover, ameliorated via redox environment, oxygen content, pH value site. have capacity provide site-specific delivery therapeutic agents, controlled release, enhanced solubility stability, decreased toxicities, pharmacokinetics as well biodistribution. Numerous demonstrated their potential inducing distinct mechanisms delivering various preclinical studies, including metal NCs, liposomal solid lipid micelles, nanoemulsions, polymer-based dendrimers, nanoclays, nanocrystals, many more. Some them already received US Food Drug Administration approval, some entered different clinical phases. However, there are several challenges NC-mediated targeting, scale-up NC-based therapy, rapid clearance mononuclear phagocyte system, heterogeneity. In order harness full treatment, that need carefully studied, optimization loading into NC-associated immunogenicity, biocompatibility for successful translation therapies practice. this review, applications remodel therapy extensively discussed. findings from numerous studies these also highlighted.

Язык: Английский

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Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis

ACS Infectious Diseases, Год журнала: 2023, Номер 9(5), С. 1137 - 1149

Опубликована: Апрель 27, 2023

The search for novel therapeutic strategies to treat fungal diseases is of special importance nowadays given the emerging threat drug resistance. Various particulate delivery systems are extensively being developing enhance bioavailability, site-specific penetration, and efficacy antimycotics. Recently, we have designed a topical formulation griseofulvin (Gf) drug, which currently commercially available in oral dosage forms due its limited skin permeation. proposed based on vaterite carriers that enabled effective incorporation ultrasonically assisted Gf hair follicles improving dermal bioavailability. Here, evaluated effect ultrasound viability murine fibroblasts co-incubated with either Gf-loaded or free form investigated influence both different subpopulations blood cells. study revealed no sufficient cyto- hemotoxicity carriers, even at highest concentrations. We also conducted series vivo experiments assess their multi-dose toxicity antifungal efficiency. Visual histological examinations healthy rabbits showed obvious adverse effects after US-assisted application carriers. At same time, investigation efficiency comparison isoconazole drugs guinea pig model trichophytosis vaterite-based provided most rapid cure infected animals together reduction procedure number. These findings pave way therapy superficial mycoses justifying further preclinical studies.

Язык: Английский

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On-chip fabrication of calcium carbonate nanoparticles loaded with various compounds using microfluidic approach

Biomaterials Advances, Год журнала: 2024, Номер 161, С. 213904 - 213904

Опубликована: Май 23, 2024

Язык: Английский

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