Mitochondria-targeted liposome-enveloped covalent organic framework co-delivery system for enhanced tumor therapy

Microporous and Mesoporous Materials, Год журнала: 2022, Номер 344, С. 112198 - 112198

Опубликована: Авг. 30, 2022

Язык: Английский

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RETRACTED: Theoretical simulation and experimental design of selenium and gold incorporated polymer-based microcarriers for ROS-mediated combined photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 643, С. 232 - 246

Опубликована: Апрель 10, 2023

Язык: Английский

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A review on selenium and gold nanoparticles combined photodynamic and photothermal prostate cancer tumors ablation

Discover Nano, Год журнала: 2023, Номер 18(1)

Опубликована: Дек. 7, 2023

Abstract The acceptance of nanoparticle technology in the quest for cancer treatment is due to its many potentials and possibilities filling gaps limitations current modalities. Insights into getting even more from this technology, as well synergistic properties photothermal therapy (PTT) photodynamic (PDT)—the use reactive oxygen species (ROS)—can also be exploited ablation prostate tumors. Therefore, combination gold selenium photoactive nanoparticles platforms drug delivery via PTT/PDT therapy, with a specific emphasis on 'micro-carrier' based approach, was discussed explored review under relevant subtopics ranging understanding complex chemistry biology pharmacologically active Se/Au-containing agents giving thorough knowledge these therapeutic agents' potential targeted successful strategy by investigating mechanisms behind their delivery, activation, effects. Furthermore, article presents comprehensive overview research environment, problems encountered, future perspectives continuous war against cancer.

Язык: Английский

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Multifunctional Inorganic–Organic Composite Carriers for Synergistic Dual Therapy of Melanoma

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(4), С. 2324 - 2336

Опубликована: Март 23, 2024

Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration PTT is main drawback. To improve therapeutic efficiency, development combined with other agents highly desirable. In this work, we designed multifunctional composite carriers based on polylactic acid (PLA) particles decorated gold nanorods (Au NRs) as nanoheaters selenium nanoparticles (Se NPs) reactive oxygen species (ROS) production in order perform against B16-F10 melanoma. do this, optimized synthesis PLA modified Se NPs Au NRs (PLA-Se:Au), studied cellular interactions cells, analyzed vivo biodistribution tumor inhibition efficiency. The results vitro experiments demonstrated synergistic effect from ROS induced by heating NRs. melanoma tumor-bearing mice, intratumoral injection PLA-Se:Au followed laser irradiation leads almost complete elimination tissues. Thus, optimal properties ROS-generating capacity allow us recommend promising candidate

Язык: Английский

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Targeted delivery of activatable 131I-radiopharmaceutical for sustained radiotherapy with improved pharmacokinetics

Journal of Controlled Release, Год журнала: 2024, Номер 373, С. 967 - 977

Опубликована: Июль 20, 2024

Язык: Английский

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