Abstract
It
is
widely
recognized
that
platinum‐based
chemotherapy,
particularly
cisplatin
therapy,
can
cause
ototoxicity.
At
present,
there
are
no
Food
and
Drug
Administration‐approved
drugs
to
prevent
or
alleviate
Ototoxicity
generally
believed
be
caused
by
excessive
reactive
oxygen
species
production
in
the
inner
ear.
Accordingly,
a
variety
of
antioxidants
have
been
developed
protect
against
To
improve
efficiency
drug
delivery
cochlea,
here,
we
synthesized
simple
easy‐to‐obtain
glutathione
carbon
dots
(GSH
CDs)
with
ultra‐small
dimensions.
The
experimental
results
revealed
GSH
CDs
strong
free‐radical
scavenging
activity
restore
mitochondrial
function,
maintain
hair
cell
stability,
cells
from
cisplatin‐induced
oxidative
stress.
Thus,
may
serve
as
new
therapeutic
agent
for
preventing
Abstract
Ferroptosis,
a
novel
form
of
nonapoptotic
cell
death,
can
effectively
enhance
photodynamic
therapy
(PDT)
performance
by
disrupting
intracellular
redox
homeostasis
and
promoting
apoptosis.
However,
the
extremely
hypoxic
tumor
microenvironment
(TME)
together
with
highly
expressed
hypoxia‐inducible
factor‐1α
(HIF‐1α)
presents
considerable
challenge
for
clinical
PDT
against
osteosarcoma
(OS).
Hence,
an
innovative
nanoplatform
that
enhances
antitumor
inducing
ferroptosis
alleviating
hypoxia
is
fabricated.
Capsaicin
(CAP)
widely
reported
to
specifically
activate
transient
receptor
potential
vanilloid
1
(TRPV1)
channel,
trigger
increase
in
Ca
2+
concentration,
which
closely
linked
ferroptosis,
participate
decreased
oxygen
consumption
inhibiting
HIF‐1α
cells,
potentiating
efficiency.
Thus,
CAP
photosensitizer
IR780
are
coencapsulated
into
biocompatible
human
serum
albumin
(HSA)
construct
(CI@HSA
NPs)
synergistic
treatment
under
near‐infrared
(NIR)
irradiation.
Furthermore,
underlying
signaling
pathways
combination
investigated.
CI@HSA
NPs
achieve
real‐time
dynamic
distribution
monitoring
exhibit
excellent
efficacy
superior
biosafety
vivo.
Overall,
this
work
highlights
promising
NIR
imaging‐guided
“pro‐death”
strategy
overcome
limitations
OS
hypoxia,
providing
inspiration
support
future
approaches.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
12(12), С. 4472 - 4485
Опубликована: Авг. 19, 2022
Hydrogen
sulfide
(H2S)
is
the
most
recently
discovered
gasotransmitter
molecule
that
activates
multiple
intracellular
signaling
pathways
and
exerts
concentration-dependent
antitumor
effect
by
interfering
with
mitochondrial
respiration
inhibiting
cellular
ATP
generation.
Inspired
fact
H2S
can
also
serve
as
a
promoter
for
Ca2+
influx,
tumor-specific
nanomodulators
([email
protected])
have
been
constructed
encapsulating
calcium
(CaS)
indocyanine
green
(ICG)
into
methoxy
poly
(ethylene
glycol)-b-poly
(lactide-co-glycolide)
(PLGA-PEG).
[email
protected]
achieve
biodegradability
high
biocompatibility
pH-responsive
release.
The
released
effectively
suppress
catalase
(CAT)
activity
synergize
to
facilitate
abnormal
retention
in
cells,
thus
leading
mitochondria
destruction
amplification
of
oxidative
stress.
Mitochondrial
dysfunction
further
contributes
blocking
synthesis
downregulating
heat
shock
proteins
(HSPs)
expression,
which
beneficial
overcome
endurance
tumor
cells
strengthen
ICG-induced
photothermal
performance.
Such
H2S-boosted
Ca2+-involved
therapy
exhibits
highly
effective
inhibition
almost
complete
elimination
within
14-day
treatment,
indicating
great
prospect
CaS-based
therapeutics.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2023,
Номер
18(4), С. 100829 - 100829
Опубликована: Июль 1, 2023
Current
antitumor
monotherapy
has
many
limitations,
highlighting
the
need
for
novel
synergistic
anticancer
strategies.
Ferroptosis
is
an
iron-dependent
form
of
nonapoptotic
cell
death
that
plays
a
pivotal
regulatory
role
in
tumorigenesis
and
treatment.
Photodynamic
therapy
(PDT)
causes
irreversible
chemical
damage
to
target
lesions
widely
used
therapy.
However,
PDT's
effectiveness
usually
hindered
by
several
obstacles,
such
as
hypoxia,
excess
glutathione
(GSH),
tumor
resistance.
improves
efficacy
PDT
increasing
oxygen
reactive
species
(ROS)
or
reducing
GSH
levels,
also
enhances
ferroptosis
induction
due
ROS
effect
microenvironment
(TME).
Strategies
based
on
nanoparticles
(NPs)
can
subtly
exploit
potential
synergy
PDT.
This
review
explores
recent
advances
current
challenges
landscape
underlying
mechanisms
regulating
PDT,
well
nano
delivery
system-mediated
activity.
These
include
polymers,
biomimetic
materials,
metal
organic
frameworks
(MOFs),
inorganics,
carrier-free
NPs.
Finally,
we
highlight
future
perspectives
this
emerging
paradigm
targeted
cancer
therapies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14614 - 14614
Опубликована: Сен. 27, 2023
Lung
adenocarcinoma
(LUAD)
is
the
most
common
lung
cancer,
which
accounts
for
about
35-40%
of
all
cancer
patients.
Despite
therapeutic
advancements
in
recent
years,
overall
survival
time
LUAD
patients
still
remains
poor,
especially
KRAS
mutant
LUAD.
Therefore,
it
necessary
to
further
explore
novel
targets
and
drugs
improve
prognos
Ferroptosis,
an
iron-dependent
regulated
cell
death
(RCD)
caused
by
lipid
peroxidation,
has
attracted
much
attention
recently
as
alternative
target
apoptosis
therapy.
Ferroptosis
been
found
be
closely
related
at
every
stage,
including
initiation,
proliferation,
progression.
In
this
review,
we
will
provide
a
comprehensive
overview
ferroptosis
mechanisms,
its
regulation
LUAD,
application
targeting
Biomedical Technology,
Год журнала:
2023,
Номер
3, С. 40 - 51
Опубликована: Янв. 23, 2023
Fenton
and
like
reaction
have
been
well
clarified
as
efficient
reactive
oxygen
species
(ROS)
sources
in
tumor,
widely
developed
into
a
cancer
treatment
method.
Meanwhile,
transition
metal-based
nanomaterials
with
or
characteristics
also
explored
therapeutic
agents
for
the
therapy,
mainly
chemo-dynamic
ferroptosis
induced
therapy.
Herein,to
summarize
recent
advances
mediated
nanoparticles
this
minireview,
we
first
introduced
mechanisms
of
two
methods
based
on
reaction,
then
well-designed
Fenton-like
therapies.
Finally
its
challenges
perspectives
are
discussed.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(5), С. 1379 - 1392
Опубликована: Янв. 1, 2024
The
constructed
ZnS–Ti
3
C
2
/PLLA
scaffolds
were
able
to
release
H
S
gas
disrupt
biofilm
and
further
remove
bacteria
through
photothermal.
In
addition,
the
Zn
2+
released
from
composite
could
promote
osteogenic
differentiation
of
BMSCs.
