Abstract
The
primary
function
of
the
kidneys
is
to
maintain
systemic
homeostasis
(disruption
renal
structure
and
results
in
multilevel
impairment
body
function).
Kidney
diseases
are
characterized
by
a
chronic,
progressive
course
may
result
development
chronic
kidney
disease
(CKD).
Evaluation
composition
proteome
urinary
small
extracellular
vesicles
(sEVs)
as
so‐called
liquid
biopsy
promising
new
research
direction.
Knowing
sEV
could
allow
localization
cellular
changes
specific
sections
nephron
or
interstitial
tissue
before
fixed
changes,
detectable
only
at
an
advanced
stage
disease,
occur.
Research
currently
underway
on
role
sEVs
diagnosis
monitoring
many
entities.
Reports
literature
subject
include:
diabetic
nephropathy,
focal
glomerulosclerosis
glomerulopathies,
fibrosis
various
etiologies.
Studies
pediatric
patients
still
few,
involving
piloting
if
groups
without
validation
studies.
Here,
we
review
addressing
use
for
most
common
disorders
children.
We
evaluate
clinical
utility
define
limitations
markers
present
potential
biopsy.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
nano-platform
(GE11-HGFI@ND-DOX)
capable
of
specifically
targeting
colorectal
cancer
HCT-116
cells
with
highly
expressed
EGFR
receptors,
exhibiting
precise
and
enhanced
therapy,
while
enhancing
its
dispersivity
hydrophilicity
is
reported.
This
work
opens
up
prospects
for
the
development
synergistic
targeted
therapy
by
integrating
hydrophobins
nanodiamond
encapsulated
drug
delivery
systems.
Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2699 - 2699
Опубликована: Дек. 2, 2022
The
clinical
translation
of
messenger
mRNA
(mRNA)-based
therapeutics
requires
safe
and
effective
delivery
systems.
Although
considerable
progress
has
been
made
on
the
development
systems,
many
challenges,
such
as
dose-limiting
toxicity
specific
to
extrahepatic
tissues,
still
remain.
Cell-derived
vesicles,
a
type
endogenous
membranous
particle
secreted
from
living
cells,
can
be
leveraged
load
during
or
after
their
biogenesis.
Currently,
they
have
received
increasing
interest
for
due
natural
origin,
good
biocompatibility,
cell-specific
tropism,
unique
ability
cross
physiological
barriers.
In
this
review,
we
provide
an
overview
recent
advances
in
naturally
occurring
platforms
biomedical
applications.
Furthermore,
future
perspectives
cell-derived
vesicles
discussed.
Genes,
Год журнала:
2023,
Номер
14(3), С. 609 - 609
Опубликована: Фев. 28, 2023
The
prevalence
of
diabetes
is
increasing
globally,
and
this
trend
predicted
to
continue
for
future
decades.
Research
needed
uncover
new
ways
manage
its
co-morbidities.
A
significant
secondary
complication
kidney
disease,
which
can
ultimately
result
in
the
need
renal
replacement
therapy,
via
dialysis
or
transplantation.
Diabetic
disease
presents
a
substantial
burden
patients,
their
families
global
healthcare
services.
This
review
highlights
studies
that
have
harnessed
genomic,
epigenomic
functional
prediction
tools
novel
genes
pathways
associated
with
DKD
are
useful
identification
therapeutic
targets
biomarkers
risk
stratification.
Telomere
length
regulation
specific
pathway
gaining
attention
recently
because
association
DKD.
Researchers
employing
both
observational
genetics-based
identify
telomere-related
function
decline
diabetes.
Studies
also
uncovered
functions
beyond
immediate
telomere
length,
such
as
transcriptional
inflammation.
summarises
revealed
potential
harness
therapeutics
modulate
epigenetic
modifications,
treatment
DKD,
potentially
slow
reduce
disease.
Abstract
The
primary
function
of
the
kidneys
is
to
maintain
systemic
homeostasis
(disruption
renal
structure
and
results
in
multilevel
impairment
body
function).
Kidney
diseases
are
characterized
by
a
chronic,
progressive
course
may
result
development
chronic
kidney
disease
(CKD).
Evaluation
composition
proteome
urinary
small
extracellular
vesicles
(sEVs)
as
so‐called
liquid
biopsy
promising
new
research
direction.
Knowing
sEV
could
allow
localization
cellular
changes
specific
sections
nephron
or
interstitial
tissue
before
fixed
changes,
detectable
only
at
an
advanced
stage
disease,
occur.
Research
currently
underway
on
role
sEVs
diagnosis
monitoring
many
entities.
Reports
literature
subject
include:
diabetic
nephropathy,
focal
glomerulosclerosis
glomerulopathies,
fibrosis
various
etiologies.
Studies
pediatric
patients
still
few,
involving
piloting
if
groups
without
validation
studies.
Here,
we
review
addressing
use
for
most
common
disorders
children.
We
evaluate
clinical
utility
define
limitations
markers
present
potential
biopsy.