Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery DOI Creative Commons

Munire Abudurexiti,

Yue Zhao, Wang Xiao-ling

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 2011 - 2011

Опубликована: Июль 24, 2023

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components cells, are natural nanoscale particles that transport variety biological molecules and facilitate cell-to-cell communication which been also widely used targeted drug delivery. These nanocarriers exhibit inherent advantages, such strong cell or tissue targeting low immunogenicity, synthetic lack. However, despite tremendous therapeutic EVs, further clinical application is still limited by yield lack standardized isolation purification protocols. In recent years, inspired concept biomimetics, new approach to biomimetic delivery has developed through combining nanotechnology bioengineering. This article reviews derived from EVs discusses advantages challenges order stimulate future research.

Язык: Английский

Advancing stroke therapy: innovative approaches with stem cell-derived extracellular vesicles DOI Creative Commons
Jiahao Song, Da Zhou, Lili Cui

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 22, 2024

Abstract Stroke is a leading cause of mortality and long-term disability globally, with acute ischemic stroke (AIS) being the most common subtype. Despite significant advances in reperfusion therapies, their limited time window associated risks underscore necessity for novel treatment strategies. Stem cell-derived extracellular vesicles (EVs) have emerged as promising therapeutic approach due to ability modulate post-stroke microenvironment facilitate neuroprotection neurorestoration. This review synthesizes current research on potential stem EVs AIS, focusing origin, biogenesis, mechanisms action, strategies enhancing targeting capacity efficacy. Additionally, we explore innovative combination therapies discuss both challenges prospects EV-based treatments. Our findings reveal that exhibit diverse effects such promoting neuronal survival, diminishing neuroinflammation, protecting blood-brain barrier, angiogenesis neurogenesis. Various strategies, including modifications cargo modifications, been developed improve efficacy EVs. Combining other treatments, therapy, cell transplantation, nanomedicine, gut microbiome modulation, holds great promise improving outcomes. However, heterogeneity need standardized protocols EV production quality control remain be addressed. represent avenue offering address limitations Further needed optimize translate benefits clinical practice, an emphasis ensuring safety, overcoming regulatory hurdles, specificity delivery target tissues. Graphical

Язык: Английский

Процитировано

7

Extracellular vesicles secreted by leukemic cells as mediators of dysregulated hematopoiesis: acute myeloid leukemia as a case in point DOI

Vishakha Kasherwal,

Vaijayanti Kale, Anuradha Vaidya

и другие.

Expert Review of Hematology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Acute myeloid leukemia (AML) cells exhibit a profound capacity for resistance to conventional chemotherapeutic agents, posing substantial challenge existing therapeutic paradigms. Interestingly, this happens in the face of luxuriant proliferation leukemic blasts peripheral blood. This paradox concurrent proliferative activity and cellular quiescence underscores complex biological phenomenon that is intricately mediated by AML-derived Extracellular vesicles (EVs). An extensive literature review search was done on Pubmed/Scopus/Web Sciences databases identify studies published between 2013 2024 elucidating demonstrating effect EVs, Microvesicles (MVs) Exosomes (Exos) regulating normal dysregulated bone marrow (BM) niche. The delves into understanding molecular mechanisms underlying dual behavior AML - quiescence, with special focus role EVs their subtypes viz. Exos MVs establishing discrete BM microenvironment subversive chemotherapy. It offers novel perspective intricate interplay microenvironment, implications interventions targeting persistence drug resistance.

Язык: Английский

Процитировано

1

Enhanced Insecticidal Activity of Chlorfenapyr against Spodoptera frugiperda by Reshaping the Intestinal Microbial Community and Interfering with the Metabolism of Iron-Based Metal–Organic Frameworks DOI

Huiya Chen,

Liupeng Yang,

Jingtong Zhou

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(30), С. 36036 - 36051

Опубликована: Июль 24, 2023

Spodoptera frugiperda (S. frugiperda) is an invasive pest that threatens global crop production and food security poses a serious threat to maize worldwide. Metal-organic framework (MOF) nanocarriers have great potential for agricultural control applications. The present study successfully prepared the chemical cross-linking of iron-based metal-organic nanoparticles (MIL-101(Fe)-NH2 NPs) with sodium lignosulfonate (SL) as pH/laccase double stimuli-responsive pesticide release system. average particle size chlorfenapyr (CF)-loaded (CF@MIL-101-SL was 161.54 nm, loading efficiency 44.52%. Bioactivity assays showed CF@MIL-101-SL NPs increased toxicity CF S. caused rupture peritrophic membrane enlargement midgut. Data from 16S rRNA gene sequencing treatment reduced resistance pesticides pathogens affected nutrient energy availability by remodeling intestinal microbiota frugiperda. dysregulated microbial community interacted broken membrane, which exacerbated damage host. Nontargeted metabolomic results ABC transporters may be mechanism enhanced In summary, provides effective strategies toxicological studies nanopesticides against insects.

Язык: Английский

Процитировано

17

Apoptotic Vesicles of MSCs: The Natural Therapeutic Agents and Bio‐Vehicles for Targeting Drug Delivery DOI Open Access
Ruyi Lin, Tianyuan Zhang, Jianqing Gao

и другие.

Small, Год журнала: 2023, Номер 19(47)

Опубликована: Июль 25, 2023

Mesenchymal stem cell (MSC)-based therapies are increasingly recognized as promising cellular therapeutics and show the ability to treat various diseases. However, underlying mechanism is not fully elucidated. Some recent studies have shown an unexpected result whereby MSCs undergo rapid apoptosis following administration but still exert therapeutic effects in some disease treatments. Such a believed associate with released apoptotic vesicles from (MSC-ApoVs). This finding inspires novel strategy for using MSC-ApoVs treatment. The present review aims summarize biogenesis, physiological functions, potentials, related mechanisms of MSC-based therapy. In addition, potential applications natural agents drug delivery vehicles proposed highlighted. hoped provide general understanding treatment inspire targeted delivery.

Язык: Английский

Процитировано

16

Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery DOI Creative Commons

Munire Abudurexiti,

Yue Zhao, Wang Xiao-ling

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 2011 - 2011

Опубликована: Июль 24, 2023

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components cells, are natural nanoscale particles that transport variety biological molecules and facilitate cell-to-cell communication which been also widely used targeted drug delivery. These nanocarriers exhibit inherent advantages, such strong cell or tissue targeting low immunogenicity, synthetic lack. However, despite tremendous therapeutic EVs, further clinical application is still limited by yield lack standardized isolation purification protocols. In recent years, inspired concept biomimetics, new approach to biomimetic delivery has developed through combining nanotechnology bioengineering. This article reviews derived from EVs discusses advantages challenges order stimulate future research.

Язык: Английский

Процитировано

15