Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 27, 2024
The
concept
of
Yin-Yang,
originating
in
ancient
Chinese
philosophy,
symbolizes
two
opposing
but
complementary
forces
or
principles
found
all
aspects
life.
This
can
be
quite
fitting
the
context
extracellular
vehicles
(EVs)
and
inflammatory
diseases.
Over
past
decades,
numerous
studies
have
revealed
that
EVs
exhibit
dual
sides,
acting
as
both
pro-
anti-inflammatory
agents,
akin
to
Yin-Yang
theory
(i.e.,
sides
a
coin).
has
enabled
serve
potential
indicators
pathogenesis
manipulated
for
therapeutic
purposes
by
influencing
immune
pathways.
review
delves
into
recent
advances
understanding
their
regulation
specific
We
shed
light
on
current
prospects
engineering
treating
conditions.
principle
bestows
upon
them
great
as,
therapeutic,
preventive
agents
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(30), С. 36036 - 36051
Опубликована: Июль 24, 2023
Spodoptera
frugiperda
(S.
frugiperda)
is
an
invasive
pest
that
threatens
global
crop
production
and
food
security
poses
a
serious
threat
to
maize
worldwide.
Metal-organic
framework
(MOF)
nanocarriers
have
great
potential
for
agricultural
control
applications.
The
present
study
successfully
prepared
the
chemical
cross-linking
of
iron-based
metal-organic
nanoparticles
(MIL-101(Fe)-NH2
NPs)
with
sodium
lignosulfonate
(SL)
as
pH/laccase
double
stimuli-responsive
pesticide
release
system.
average
particle
size
chlorfenapyr
(CF)-loaded
(CF@MIL-101-SL
was
161.54
nm,
loading
efficiency
44.52%.
Bioactivity
assays
showed
CF@MIL-101-SL
NPs
increased
toxicity
CF
S.
caused
rupture
peritrophic
membrane
enlargement
midgut.
Data
from
16S
rRNA
gene
sequencing
treatment
reduced
resistance
pesticides
pathogens
affected
nutrient
energy
availability
by
remodeling
intestinal
microbiota
frugiperda.
dysregulated
microbial
community
interacted
broken
membrane,
which
exacerbated
damage
host.
Nontargeted
metabolomic
results
ABC
transporters
may
be
mechanism
enhanced
In
summary,
provides
effective
strategies
toxicological
studies
nanopesticides
against
insects.
Mesenchymal
stem
cell
(MSC)-based
therapies
are
increasingly
recognized
as
promising
cellular
therapeutics
and
show
the
ability
to
treat
various
diseases.
However,
underlying
mechanism
is
not
fully
elucidated.
Some
recent
studies
have
shown
an
unexpected
result
whereby
MSCs
undergo
rapid
apoptosis
following
administration
but
still
exert
therapeutic
effects
in
some
disease
treatments.
Such
a
believed
associate
with
released
apoptotic
vesicles
from
(MSC-ApoVs).
This
finding
inspires
novel
strategy
for
using
MSC-ApoVs
treatment.
The
present
review
aims
summarize
biogenesis,
physiological
functions,
potentials,
related
mechanisms
of
MSC-based
therapy.
In
addition,
potential
applications
natural
agents
drug
delivery
vehicles
proposed
highlighted.
hoped
provide
general
understanding
treatment
inspire
targeted
delivery.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 2011 - 2011
Опубликована: Июль 24, 2023
With
their
seemingly
limitless
capacity
for
self-improvement,
stem
cells
have
a
wide
range
of
potential
uses
in
the
medical
field.
Stem-cell-secreted
extracellular
vesicles
(EVs),
as
paracrine
components
cells,
are
natural
nanoscale
particles
that
transport
variety
biological
molecules
and
facilitate
cell-to-cell
communication
which
been
also
widely
used
targeted
drug
delivery.
These
nanocarriers
exhibit
inherent
advantages,
such
strong
cell
or
tissue
targeting
low
immunogenicity,
synthetic
lack.
However,
despite
tremendous
therapeutic
EVs,
further
clinical
application
is
still
limited
by
yield
lack
standardized
isolation
purification
protocols.
In
recent
years,
inspired
concept
biomimetics,
new
approach
to
biomimetic
delivery
has
developed
through
combining
nanotechnology
bioengineering.
This
article
reviews
derived
from
EVs
discusses
advantages
challenges
order
stimulate
future
research.
Cells,
Год журнала:
2024,
Номер
13(6), С. 495 - 495
Опубликована: Март 12, 2024
From
the
moment
a
cell
is
on
path
to
malignant
transformation,
its
interaction
with
other
cells
from
microenvironment
becomes
altered.
The
flow
of
molecular
information
at
heart
cellular
and
systemic
fate
in
tumors,
various
processes
participate
conveying
key
or
certain
cancer
cells.
For
instance,
loss
tight
junction
molecules
part
signal
sent
so
that
they
are
no
longer
bound
primary
tumors
thus
free
travel
metastasize.
Upon
targeting
single
by
therapeutic
drug,
gap
junctions
able
communicate
death
by-standing
discovery
importance
novel
modes
cell–cell
communication
such
as
different
types
extracellular
vesicles
tunneling
nanotubes
changing
way
scientists
look
these
processes.
However,
all
actively
involved
contexts
same
time
recruited
fulfill
specific
tasks?
What
does
multiplicity
mean
for
overall
progression
disease?
Here,
we
extend
an
open
invitation
think
about
significance
questions,
rather
than
engage
elusive
attempt
systematic
repertory
mechanisms
play.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 27, 2024
The
concept
of
Yin-Yang,
originating
in
ancient
Chinese
philosophy,
symbolizes
two
opposing
but
complementary
forces
or
principles
found
all
aspects
life.
This
can
be
quite
fitting
the
context
extracellular
vehicles
(EVs)
and
inflammatory
diseases.
Over
past
decades,
numerous
studies
have
revealed
that
EVs
exhibit
dual
sides,
acting
as
both
pro-
anti-inflammatory
agents,
akin
to
Yin-Yang
theory
(i.e.,
sides
a
coin).
has
enabled
serve
potential
indicators
pathogenesis
manipulated
for
therapeutic
purposes
by
influencing
immune
pathways.
review
delves
into
recent
advances
understanding
their
regulation
specific
We
shed
light
on
current
prospects
engineering
treating
conditions.
principle
bestows
upon
them
great
as,
therapeutic,
preventive
agents
