Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 2011 - 2011
Опубликована: Июль 24, 2023
With
their
seemingly
limitless
capacity
for
self-improvement,
stem
cells
have
a
wide
range
of
potential
uses
in
the
medical
field.
Stem-cell-secreted
extracellular
vesicles
(EVs),
as
paracrine
components
cells,
are
natural
nanoscale
particles
that
transport
variety
biological
molecules
and
facilitate
cell-to-cell
communication
which
been
also
widely
used
targeted
drug
delivery.
These
nanocarriers
exhibit
inherent
advantages,
such
strong
cell
or
tissue
targeting
low
immunogenicity,
synthetic
lack.
However,
despite
tremendous
therapeutic
EVs,
further
clinical
application
is
still
limited
by
yield
lack
standardized
isolation
purification
protocols.
In
recent
years,
inspired
concept
biomimetics,
new
approach
to
biomimetic
delivery
has
developed
through
combining
nanotechnology
bioengineering.
This
article
reviews
derived
from
EVs
discusses
advantages
challenges
order
stimulate
future
research.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Stroke
is
a
leading
cause
of
mortality
and
long-term
disability
globally,
with
acute
ischemic
stroke
(AIS)
being
the
most
common
subtype.
Despite
significant
advances
in
reperfusion
therapies,
their
limited
time
window
associated
risks
underscore
necessity
for
novel
treatment
strategies.
Stem
cell-derived
extracellular
vesicles
(EVs)
have
emerged
as
promising
therapeutic
approach
due
to
ability
modulate
post-stroke
microenvironment
facilitate
neuroprotection
neurorestoration.
This
review
synthesizes
current
research
on
potential
stem
EVs
AIS,
focusing
origin,
biogenesis,
mechanisms
action,
strategies
enhancing
targeting
capacity
efficacy.
Additionally,
we
explore
innovative
combination
therapies
discuss
both
challenges
prospects
EV-based
treatments.
Our
findings
reveal
that
exhibit
diverse
effects
such
promoting
neuronal
survival,
diminishing
neuroinflammation,
protecting
blood-brain
barrier,
angiogenesis
neurogenesis.
Various
strategies,
including
modifications
cargo
modifications,
been
developed
improve
efficacy
EVs.
Combining
other
treatments,
therapy,
cell
transplantation,
nanomedicine,
gut
microbiome
modulation,
holds
great
promise
improving
outcomes.
However,
heterogeneity
need
standardized
protocols
EV
production
quality
control
remain
be
addressed.
represent
avenue
offering
address
limitations
Further
needed
optimize
translate
benefits
clinical
practice,
an
emphasis
ensuring
safety,
overcoming
regulatory
hurdles,
specificity
delivery
target
tissues.
Graphical
Expert Review of Hematology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Acute
myeloid
leukemia
(AML)
cells
exhibit
a
profound
capacity
for
resistance
to
conventional
chemotherapeutic
agents,
posing
substantial
challenge
existing
therapeutic
paradigms.
Interestingly,
this
happens
in
the
face
of
luxuriant
proliferation
leukemic
blasts
peripheral
blood.
This
paradox
concurrent
proliferative
activity
and
cellular
quiescence
underscores
complex
biological
phenomenon
that
is
intricately
mediated
by
AML-derived
Extracellular
vesicles
(EVs).
An
extensive
literature
review
search
was
done
on
Pubmed/Scopus/Web
Sciences
databases
identify
studies
published
between
2013
2024
elucidating
demonstrating
effect
EVs,
Microvesicles
(MVs)
Exosomes
(Exos)
regulating
normal
dysregulated
bone
marrow
(BM)
niche.
The
delves
into
understanding
molecular
mechanisms
underlying
dual
behavior
AML
-
quiescence,
with
special
focus
role
EVs
their
subtypes
viz.
Exos
MVs
establishing
discrete
BM
microenvironment
subversive
chemotherapy.
It
offers
novel
perspective
intricate
interplay
microenvironment,
implications
interventions
targeting
persistence
drug
resistance.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(30), С. 36036 - 36051
Опубликована: Июль 24, 2023
Spodoptera
frugiperda
(S.
frugiperda)
is
an
invasive
pest
that
threatens
global
crop
production
and
food
security
poses
a
serious
threat
to
maize
worldwide.
Metal-organic
framework
(MOF)
nanocarriers
have
great
potential
for
agricultural
control
applications.
The
present
study
successfully
prepared
the
chemical
cross-linking
of
iron-based
metal-organic
nanoparticles
(MIL-101(Fe)-NH2
NPs)
with
sodium
lignosulfonate
(SL)
as
pH/laccase
double
stimuli-responsive
pesticide
release
system.
average
particle
size
chlorfenapyr
(CF)-loaded
(CF@MIL-101-SL
was
161.54
nm,
loading
efficiency
44.52%.
Bioactivity
assays
showed
CF@MIL-101-SL
NPs
increased
toxicity
CF
S.
caused
rupture
peritrophic
membrane
enlargement
midgut.
Data
from
16S
rRNA
gene
sequencing
treatment
reduced
resistance
pesticides
pathogens
affected
nutrient
energy
availability
by
remodeling
intestinal
microbiota
frugiperda.
dysregulated
microbial
community
interacted
broken
membrane,
which
exacerbated
damage
host.
Nontargeted
metabolomic
results
ABC
transporters
may
be
mechanism
enhanced
In
summary,
provides
effective
strategies
toxicological
studies
nanopesticides
against
insects.
Mesenchymal
stem
cell
(MSC)-based
therapies
are
increasingly
recognized
as
promising
cellular
therapeutics
and
show
the
ability
to
treat
various
diseases.
However,
underlying
mechanism
is
not
fully
elucidated.
Some
recent
studies
have
shown
an
unexpected
result
whereby
MSCs
undergo
rapid
apoptosis
following
administration
but
still
exert
therapeutic
effects
in
some
disease
treatments.
Such
a
believed
associate
with
released
apoptotic
vesicles
from
(MSC-ApoVs).
This
finding
inspires
novel
strategy
for
using
MSC-ApoVs
treatment.
The
present
review
aims
summarize
biogenesis,
physiological
functions,
potentials,
related
mechanisms
of
MSC-based
therapy.
In
addition,
potential
applications
natural
agents
drug
delivery
vehicles
proposed
highlighted.
hoped
provide
general
understanding
treatment
inspire
targeted
delivery.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 2011 - 2011
Опубликована: Июль 24, 2023
With
their
seemingly
limitless
capacity
for
self-improvement,
stem
cells
have
a
wide
range
of
potential
uses
in
the
medical
field.
Stem-cell-secreted
extracellular
vesicles
(EVs),
as
paracrine
components
cells,
are
natural
nanoscale
particles
that
transport
variety
biological
molecules
and
facilitate
cell-to-cell
communication
which
been
also
widely
used
targeted
drug
delivery.
These
nanocarriers
exhibit
inherent
advantages,
such
strong
cell
or
tissue
targeting
low
immunogenicity,
synthetic
lack.
However,
despite
tremendous
therapeutic
EVs,
further
clinical
application
is
still
limited
by
yield
lack
standardized
isolation
purification
protocols.
In
recent
years,
inspired
concept
biomimetics,
new
approach
to
biomimetic
delivery
has
developed
through
combining
nanotechnology
bioengineering.
This
article
reviews
derived
from
EVs
discusses
advantages
challenges
order
stimulate
future
research.
