Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 688, С. 250 - 263

Опубликована: Фев. 21, 2025

Язык: Английский

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sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy

Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113580 - 113580

Опубликована: Фев. 28, 2025

Язык: Английский

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Ultrasound-Driven Nitric Oxide Generation for Enhanced Sonodynamic–Photothermal Therapy

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Recently, green gas therapy based on nitric oxide (NO) has gained considerable attention in cancer treatment. The supplementation of exogenous NO and its controlled release represent promising strategies for adjuvant tumor therapy. In this study, we developed a novel ultrasound (US)-triggered generation nanoplatform that integrates therapy, sonodynamic photothermal (PTT) into collaborative therapeutic modality. An environmentally friendly biomacromolecule, polydopamine, was employed to coload chlorin e6 (Ce6) donor (BNN6), resulting the nanocomposite PDA-Ce6/BNN6 (PCB). A single US stimulus simultaneously activated Ce6 produce reactive oxygen species (ROS) promoted BNN6 NO. dual effects ultrasonic mechanical action physiological modulation by substantially improved local vascular function enhanced cell permeability, thereby increasing targeted accumulation PCB within tumors. Reactive nitrogen (RNS) derived from ROS further exacerbated oxidative damage sensitivity cells hyperthermia. Both vitro vivo experiments demonstrated stimulation NO/ROS/RNS combined with PTT effectively inhibited growth proliferation. findings suggest extracorporeal can significantly amplify efficacy offer new insights developing other aimed at physically regulating deep

Язык: Английский

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Recent advancement in the anticancer efficacy of the natural flavonoid scutellarin: a comprehensive review

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

Scutellarin (SC), a natural flavonoid, has been expansively employed in treating innumerable inflammation-related diseases due to its antitumor, antiinflammatory, anticancer, and antioxidant potential. can inhibit significant inflammatory cell signaling pathways, comprisingPI3K/Akt, NF-κB, MAPK, while activating antioxidant-related pathways such as Nrf2 ARE. Numerous reviews have outlined scutellarin’s pharmacological effects associated mechanisms diseases. Several studies elucidated the of anticancer activity by inhibiting various pathways; however, our knowledge, none distinguished potential scutellarin based on different human cancer types. Our review detailed insights about type body. Furthermore, we also formulations, combinatorial therapies, comprehensive mechanistic research deliver enhanced effective treatment options for patients. This study will provide thorough into scutellarin, supporting development promising candidate treatment.

Язык: Английский

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A Review on the Study of Ligustilide from <i>Artemisia </i><i>capillaris</i> <i>Thunb.</i>, an Active Ingredient of Tibetan Wormwood, against Colorectal Cancer

Nursing Science, Год журнала: 2025, Номер 14(04), С. 487 - 499

Опубликована: Янв. 1, 2025

Язык: Английский

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