Abstract
Pulmonary
delivery
of
therapeutic
agents
has
been
considered
the
desirable
administration
route
for
local
lung
disease
treatment.
As
latest
generation
agents,
nucleic
acid
gradually
developed
as
gene
therapy
diseases
such
asthma,
chronic
obstructive
pulmonary
diseases,
and
fibrosis.
The
features
acid,
specific
physiological
structure,
pathophysiological
barriers
respiratory
tract
have
strongly
affected
efficiency
bioavailability
directly
related
to
treatment
outcomes.
development
pharmaceutics
material
science
provides
potential
highly
effective
medicine
delivery.
In
this
review,
key
factors
are
first
introduced
that
affect
acids.
advanced
inhaled
materials
further
summarized.
recent
progress
platform
designs
improving
acids
their
outcomes
systematically
analyzed,
with
application
perspectives
vectors
ACS Materials Au,
Год журнала:
2023,
Номер
3(6), С. 600 - 619
Опубликована: Авг. 21, 2023
Over
the
past
decade,
therapeutic
potential
of
nanomaterials
as
novel
drug
delivery
systems
complementing
conventional
pharmacology
has
been
widely
acknowledged.
Among
these
nanomaterials,
lipid-based
nanoparticles
(LNPs)
have
shown
remarkable
pharmacological
performance
and
promising
outcomes,
thus
gaining
substantial
interest
in
preclinical
clinical
research.
In
this
review,
we
introduce
main
types
LNPs
used
formulations
such
liposomes,
nanoemulsions,
solid
lipid
nanoparticles,
nanostructured
carriers,
polymer
hybrid
focusing
on
their
physicochemical
properties
potential.
We
discuss
computational
studies
modeling
techniques
to
enhance
understanding
how
interact
with
cargo
predict
effectiveness
interactions
applications.
also
analyze
benefits
drawbacks
various
LNP
production
nanoprecipitation,
emulsification,
evaporation,
thin
film
hydration,
microfluidic-based
methods,
an
impingement
jet
mixer.
Additionally,
major
challenges
associated
industrial
development,
including
stability
sterilization,
storage,
regulatory
compliance,
reproducibility,
quality
control.
Overcoming
facilitating
compliance
represent
key
steps
toward
LNP's
successful
commercialization
translation
into
settings.
Advanced Materials,
Год журнала:
2023,
Номер
36(4)
Опубликована: Авг. 7, 2023
Abstract
Lipid
nanoparticles
(LNPs)
are
currently
the
most
promising
clinical
nucleic
acids
drug
delivery
vehicles.
LNPs
prevent
degradation
of
cargo
during
blood
circulation.
Upon
entry
into
cell,
specific
components
lipid
can
promote
endosomal
escape
acids.
These
basic
properties
as
acid
carriers.
As
exhibit
hepatic
aggregation
characteristics,
enhancing
targeting
out
liver
is
a
crucial
way
to
improve
administrated
in
vivo.
Meanwhile,
loaded
often
considered
inadequate,
and
therefore,
much
effort
devoted
intracellular
release
efficiency
Here,
different
strategies
efficiently
deliver
from
concluded
their
mechanisms
investigated.
In
addition,
based
on
information
that
trials
or
have
completed
trials,
issues
necessary
be
approached
translation
discussed,
which
it
hoped
will
shed
light
development
LNP
drugs.
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 186 - 186
Опубликована: Фев. 12, 2024
In
recent
years,
lipid
nanoparticles
(LNPs)
have
attracted
extensive
attention
in
tumor
immunotherapy.
Targeting
immune
cells
cancer
therapy
has
become
a
strategy
of
great
research
interest.
mRNA
vaccines
are
potential
choice
for
immunotherapy,
due
to
their
ability
directly
encode
antigen
proteins
and
stimulate
strong
response.
However,
the
mode
delivery
lack
stability
key
issues
limiting
its
application.
LNPs
an
excellent
carrier,
structural
biocompatibility
make
them
effective
means
delivering
specific
targets.
This
study
summarizes
progress
LNP
carrier-assisted
targeted
controlled
release
immunity.
The
role
improving
stability,
immunogenicity,
targeting
is
discussed.
review
aims
systematically
summarize
latest
immunity
provide
new
ideas
strategies
as
well
more
treatment
plans
patients.
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
200, С. 115042 - 115042
Опубликована: Авг. 2, 2023
The
concept
of
using
mRNA
to
produce
its
own
medicine
in
situ
the
body
makes
it
an
ideal
drug
candidate,
holding
great
potential
revolutionize
way
we
approach
medicine.
unique
characteristics
mRNA,
as
well
customizable
biomedical
functions,
call
for
rational
design
delivery
systems
protect
and
transport
molecules.
In
this
review,
a
nanoparticle
toolkit
is
presented
development
mRNA-based
therapeutics
from
perspective.
Nano-delivery
derived
either
natural
or
chemical
synthesis,
nature
organic
inorganic
materials,
are
summarised.
Delivery
strategies
controlling
tissue
targeting
release,
role
nanoparticles
building
boosting
activity
drugs,
have
also
been
introduced.
end,
our
insights
into
clinical
translational
nano-drugs
presented.
ACS Nano,
Год журнала:
2024,
Номер
18(17), С. 10979 - 11024
Опубликована: Апрель 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Gene
therapy,
a
medical
approach
that
involves
the
correction
or
replacement
of
defective
and
abnormal
genes,
plays
an
essential
role
in
treatment
complex
refractory
diseases,
such
as
hereditary
cancer,
rheumatic
immune
diseases.
Nucleic
acids
alone
do
not
easily
enter
target
cells
due
to
their
easy
degradation
vivo
structure
cell
membranes.
The
introduction
genes
into
biological
is
often
dependent
on
gene
delivery
vectors,
adenoviral
which
are
commonly
used
therapy.
However,
traditional
viral
vectors
have
strong
immunogenicity
while
also
presenting
potential
infection
risk.
Recently,
biomaterials
attracted
attention
for
use
efficient
vehicles,
because
they
can
avoid
drawbacks
associated
with
vectors.
Biomaterials
improve
stability
nucleic
efficiency
intracellular
delivery.
This
review
focused
biomaterial-based
systems
therapy
disease
treatment.
Herein,
we
recent
developments
modalities
Additionally,
discuss
acid
strategies,
focus
systems.
Furthermore,
current
applications
summarized.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115065 - 115065
Опубликована: Июль 3, 2023
Ionizable
cationic
lipids
(ICLs)
play
an
essential
role
in
the
effectiveness
of
lipid
nanoparticles
(LNPs)
for
delivery
mRNA
therapeutics
and
vaccines;
therefore,
critical
evaluations
their
biological
performance
would
extend
existing
knowledge
field.
In
present
study,
we
examined
effects
three
clinically-approved
ICLs,
Dlin-MC3-DMA,
ALC-0315
SM-102,
as
well
DODAP,
on
vitro
vivo
LNPs
vaccine
efficacy.
mRNA-LNPs
containing
these
were
successfully
prepared,
which
all
found
to
be
very
similar
physicochemical
properties
encapsulation
efficiencies.
Furthermore,
results
studies
indicated
that
efficiently
taken
up
by
immortalized
primary
immune
cells
with
comparable
efficiency;
however,
SM-102-based
superior
inducing
protein
expression
antigen-specific
T
cell
proliferation.
contrast,
revealed
SM-102
yielded
almost
identical
levels
zebrafish
embryos,
significantly
higher
than
Dlin-MC3-DMA-based
LNPs.
Additionally,
a
mouse
immunization
study
demonstrated
single-dose
subcutaneous
administration
resulted
high
production
intracellular
cytokines
cells,
but
no
significant
differences
among
ICLs
observed,
suggesting
weak
correlation
between
outcomes.
This
provides
strong
evidence
modulate
data
does
not
adequately
predict
behavior
vivo.
