Immunogenic Potential and Therapeutic Efficacy of Multi‐Epitope Encapsulated Silk Fibroin Nanoparticles against Pseudomonas aeruginosa‐Mediated Urinary Tract Infections DOI

Azam Rezvanirad,

Mehri Habibi, Mehdi Farokhi

и другие.

Macromolecular Bioscience, Год журнала: 2023, Номер 23(9)

Опубликована: Май 10, 2023

Pseudomonas aeruginosa (P. aeruginosa) causing urinary tract infections (UTIs) are a major concern among hospital-acquired infections. The need for an effective vaccine that reduces the is imperative. This study aims to evaluate efficacy of multi-epitope encapsulated in silk fibroin nanoparticles (SFNPs) against P. aeruginosa-mediated UTIs. A constructed from nine proteins using immunoinformatic analysis, expressed, and purified BL21 (DE3) cells. encapsulation efficiency SFNPs 85% with mean particle size 130 nm 24% antigen released after 35 days. formulations adjuvanted or alum significantly improve systemic mucosal humoral responses cytokine profile (IFN-γ, IL-4, IL-17) mice. Additionally, longevity IgG response maintained at least 110 days steady state. In bladder challenge, mice treated admixed demonstrate significant protection kidneys aeruginosa. highlights promising therapeutic potential

Язык: Английский

A state-of-the-art review on solid lipid nanoparticles as a nanovaccines delivery system DOI

Marjan Assefi,

Mehrnaz Ataeinaeini,

Ahmad Nazari

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 86, С. 104623 - 104623

Опубликована: Май 30, 2023

Язык: Английский

Процитировано

21
Photoresponsive polymeric microneedles: An innovative way to monitor and treat diseases DOI
Parbeen Singh, Brian Youden,

Andrew Carrier

и другие.

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1050 - 1067

Опубликована: Дек. 22, 2022

Язык: Английский

Процитировано

18
Self-heating mitochondrion-induced free radical blast for immunogenic cell death stimulation and HCC immunotherapy DOI
Mengyun Peng, Hongyan Dong,

Meiyu Shao

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 694 - 711

Опубликована: Янв. 18, 2024

Язык: Английский

Процитировано

2
Immunogenic Potential and Therapeutic Efficacy of Multi‐Epitope Encapsulated Silk Fibroin Nanoparticles against Pseudomonas aeruginosa‐Mediated Urinary Tract Infections DOI

Azam Rezvanirad,

Mehri Habibi, Mehdi Farokhi

и другие.

Macromolecular Bioscience, Год журнала: 2023, Номер 23(9)

Опубликована: Май 10, 2023

Pseudomonas aeruginosa (P. aeruginosa) causing urinary tract infections (UTIs) are a major concern among hospital-acquired infections. The need for an effective vaccine that reduces the is imperative. This study aims to evaluate efficacy of multi-epitope encapsulated in silk fibroin nanoparticles (SFNPs) against P. aeruginosa-mediated UTIs. A constructed from nine proteins using immunoinformatic analysis, expressed, and purified BL21 (DE3) cells. encapsulation efficiency SFNPs 85% with mean particle size 130 nm 24% antigen released after 35 days. formulations adjuvanted or alum significantly improve systemic mucosal humoral responses cytokine profile (IFN-γ, IL-4, IL-17) mice. Additionally, longevity IgG response maintained at least 110 days steady state. In bladder challenge, mice treated admixed demonstrate significant protection kidneys aeruginosa. highlights promising therapeutic potential

Язык: Английский

Процитировано

6