Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 864 - 864
Опубликована: Март 7, 2023
The
cell
interaction,
mechanism
of
entry
and
intracellular
fate
surface
decorated
nanoparticles
are
known
to
be
affected
by
the
density
targeting
agents.
However,
correlation
between
multivalency
kinetics
uptake
process
disposition
compartments
is
complicated
dependent
on
a
number
physicochemical
biological
parameters,
including
ligand,
nanoparticle
composition
colloidal
properties,
features
targeted
cells,
etc.
Here,
we
have
carried
out
an
in-depth
investigation
impact
increasing
folic
acid
kinetic
endocytic
route
folate
(FA)-targeted
fluorescently
labelled
gold
(AuNPs).
A
set
AuNPs
(15
nm
mean
size)
produced
Turkevich
method
was
with
0-100
FA-PEG3.5kDa-SH
molecules/particle,
saturated
about
500
rhodamine-PEG2kDa-SH
fluorescent
probes.
In
vitro
studies
using
receptor
overexpressing
KB
cells
(KBFR-high)
showed
that
internalization
progressively
increased
ligand
density,
reaching
plateau
at
50:1
FA-PEG3.5kDa-SH/particle
ratio.
Pulse-chase
experiments
higher
FA
(50
molecules/particle)
induces
more
efficient
particle
trafficking
lysosomes,
maximum
concentration
in
lysosomes
2
h,
than
lower
10
molecules/particle.
Pharmacological
inhibition
pathways
TEM
analysis
particles
high
internalized
predominantly
clathrin-independent
process.
Theranostics,
Год журнала:
2023,
Номер
13(15), С. 5386 - 5417
Опубликована: Янв. 1, 2023
Stimuli-activatable
strategies
prevail
in
the
design
of
nanomedicine
for
cancer
theranostics.Upon
exposure
to
endogenous/exogenous
stimuli,
stimuli-activatable
could
be
self-assembled,
disassembled,
or
functionally
activated
improve
its
biosafety
and
diagnostic/therapeutic
potency.A
myriad
tumor-specific
features,
including
a
low
pH,
high
redox
level,
overexpressed
enzymes,
along
with
exogenous
physical
stimulation
sources
(light,
ultrasound,
magnet,
radiation)
have
been
considered
nano-medicinal
products.Recently,
novel
stimuli
explored
elegant
designs
emerged
nanomedicine.In
addition,
multi-functional
theranostic
has
employed
imaging-guided
image-assisted
antitumor
therapy.In
this
review,
we
rationalize
development
clinical
pressing
needs.Stimuli-activatable
self-assembly,
disassembly
functional
activation
approaches
developing
realize
better
efficacy
are
elaborated
state-of-the-art
advances
their
structural
detailed.A
reflection,
status,
future
perspectives
provided.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Янв. 19, 2024
Abstract
Humanity
is
suffering
from
cancer
which
has
become
a
root
cause
of
untimely
deaths
individuals
around
the
globe
in
recent
past.
Nanotheranostics
integrates
therapeutics
and
diagnostics
to
monitor
treatment
response
enhance
drug
efficacy
safety.
We
hereby
propose
discuss
all
imaging
diagnostic
tools,
mechanism
targeting
tumor
cells,
current
nanotheranostic
platforms
available
for
cancer.
This
review
discusses
various
agents
novel
molecular
tools
like
MRI,
CT,
PET,
SPEC,
PAT
used
diagnostics.
Emphasis
given
gold
nanoparticles,
silica,
liposomes,
dendrimers,
metal-based
agents.
also
highlight
limitations
different
field
research
treatment.
Due
complexity
this
area,
multifunctional
hybrid
nanoparticles
functionalized
with
targeted
moieties
or
anti-cancer
drugs
show
best
feature
theranostics
that
enables
them
work
on
carrying
delivering
active
materials
desired
area
requirement
early
detection
diagnosis.
Non-invasive
techniques
have
specificity
receptor
binding
internalization
processes
nanosystems
within
cells.
may
provide
appropriate
medicine
at
dose
patient
time.
Graphical
abstract
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(37)
Опубликована: Апрель 23, 2024
Abstract
Breast
cancer
stem
cells
(CSCs)
are
responsible
for
the
occurrence,
resistance,
recurrence,
invasion,
and
metastasis
of
tumors.
However,
even
trace
amounts
CSCs
may
lead
to
tumor
resistance
which
fundamentally
reduces
therapeutic
efficiency
numerous
anticancer
drugs.
Thus,
development
a
agent
that
can
reduce
tumorigenicity
overcome
recurrence
is
essential.
Here
novel
multifunctional
prodrug
T‐P
reported
as
photosensitizer,
links
phenothiazine
drug
with
synthesized
aggregation‐induced
emission
photosensitizer
T‐C
via
an
ester
bond.
Importantly,
this
found
be
able
induce
pyroptosis
breast
well
activate
their
death
pathway
protein
phosphatase
2A
inhibit
systemic
anti‐tumor
effects.
rapidly
target
mitochondria
overlap
lysosomes
after
mitochondrial
escape,
it
cause
lysosomal
dysfunction.
It
releases
reactive
oxygen
species
through
photoactivation,
triggering
pyroptosis‐mediated
strong
immune
response.
On
5th
day
in
vivo
therapy
cancer,
primary
eliminated
growth
distant
tumors
also
inhibited.
This
research
would
provide
impetus
new
strategy
CSCs‐targeted
photoimmunotherapy
beyond.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 4, 2025
The
tumor
microenvironment
(TME)
is
a
complex
and
dynamic
ecosystem
that
plays
critical
role
in
cancer
progression.
It
comprises
various
cell
types,
including
immune
cells,
stromal
cells.
Among
these,
cancer-associated
fibroblasts
(CAFs)
represent
heterogeneous
population
with
diverse
origins,
phenotypes,
functions.
Activated
CAFs
secrete
multiple
factors
promote
growth,
migration,
angiogenesis,
contribute
to
chemoresistance.
Additionally,
extracellular
matrix
(ECM)
components,
such
as
collagen,
which
form
physical
barrier
hinders
the
penetration
of
chemotherapeutic
immunotherapeutic
agents.
This
ECM
also
influences
infiltration,
impeding
their
ability
effectively
target
As
result,
modulating
activity
has
emerged
promising
strategy
enhance
efficacy
immunotherapy.
Nano-delivery
systems,
constructed
from
nanomaterials
high
targeting
specificity
biocompatibility,
offer
compelling
approach
deliver
therapeutic
agents
or
immunomodulatory
directly
CAFs.
modulation
can
alter
CAF
function,
reduce
tumor-promoting
effects,
thereby
improve
outcomes
review
provides
an
in-depth
exploration
functions,
interactions
within
TME,
particularly
context
suppression.
Furthermore,
it
discusses
potential
applications
functional
nanocarrifers
enhancing
effectiveness
immunotherapy,
highlighting
significant
progress
nanotechnology
this
area.
