Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(4)
Опубликована: Апрель 1, 2024
Breast
cancer
remains
a
global
health
challenge,
necessitating
innovative
therapeutic
approaches.
Immunomodulation
and
immunotherapy
have
emerged
as
promising
strategies
for
breast
treatment.
Engineered
exosomes
are
the
sort
of
modified
with
surface
decoration
internal
molecules.
Through
suitable
modifications,
engineered
exhibit
capability
to
overcome
limitations
associated
traditional
This
ability
opens
up
novel
avenues
development
more
effective,
personalized,
minimally
invasive
interventions.
Abstract
Regeneration
is
a
complex
process
affected
by
many
elements
independent
or
combined,
including
inflammation,
proliferation,
and
tissue
remodeling.
Stem
cells
class
of
primitive
with
the
potentiality
differentiation,
regenerate
self‐replication,
multidirectional
immunomodulatory
functions.
their
cytokines
not
only
inextricably
linked
to
regeneration
ectodermal
skin
tissues,
but
also
can
be
used
for
treatment
variety
chronic
wounds.
produce
exosomes
in
paracrine
manner.
cell
play
an
important
role
regeneration,
repair,
accelerated
wound
healing,
biological
properties
which
are
similar
stem
cells,
while
safer
more
effective.
Skin
bone
tissues
critical
organs
body,
essential
sustaining
life
activities.
The
weak
repairing
ability
leads
pronounced
impact
on
quality
patients,
could
alleviated
treatment.
However,
there
obstacles
that
trough
improved
bioavailability.
This
paper
summarizes
applications
mechanisms
healing.
We
propose
new
ways
utilizing
through
different
nanoformulations,
liposomes
nanoliposomes,
polymer
micelles,
microspheres,
hydrogels,
scaffold
microneedles,
improve
use
healing
regeneration.
Abstract
Nanozymes,
as
innovative
materials,
have
demonstrated
remarkable
potential
in
the
field
of
electrochemical
biosensors.
This
article
provides
an
overview
mechanisms
and
extensive
practical
applications
nanozymes
First,
definition
characteristics
are
introduced,
emphasizing
their
significant
role
constructing
efficient
sensors.
Subsequently,
several
common
categories
nanozyme
materials
delved
into,
including
metal‐based,
carbon‐based,
metal‐organic
framework,
layered
double
hydroxide
nanostructures,
discussing
Regarding
mechanisms,
two
key
roles
particularly
focused
biosensors:
selective
enhancement
signal
amplification,
which
crucially
support
sensor
performance.
In
terms
applications,
widespread
use
nanozyme‐based
biosensors
showcased
various
domains.
From
detecting
biomolecules,
pollutants,
nucleic
acids,
proteins,
to
cells,
providing
robust
means
for
high‐sensitivity
detection.
Furthermore,
insights
into
future
development
is
provided,
encompassing
improvements
optimizations
design
integration,
expansion
application
fields
through
interdisciplinary
collaboration.
conclusion,
this
systematically
presents
biosensors,
offering
valuable
references
prospects
research
field.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 5, 2023
B
cells
occupy
a
vital
role
in
the
functioning
of
immune
system,
working
tandem
with
T
to
either
suppress
or
promote
tumor
growth
within
microenvironment(TME).
In
addition
direct
cell-to-cell
communication,
and
other
release
exosomes,
small
membrane
vesicles
ranging
size
from
30-150
nm,
that
facilitate
intercellular
signaling.
Exosome
research
is
an
important
development
cancer
research,
as
they
have
been
shown
carry
various
molecules
such
major
histocompatibility
complex(MHC)
integrins,
which
regulate
TME.
Given
close
association
between
TME
development,
targeting
substances
has
emerged
promising
strategy
for
therapy.
This
review
aims
present
comprehensive
overview
contributions
made
by
exosomes
microenvironment
(TME).
Additionally,
we
delve
into
potential
cell-derived
progression
cancer.
Advanced Materials,
Год журнала:
2024,
Номер
36(16)
Опубликована: Янв. 24, 2024
Abstract
Abnormal
silencing
of
fibroblast
growth
factor
(FGF)
signaling
significantly
contributes
to
joint
dysplasia
and
osteoarthritis
(OA);
However,
the
clinical
translation
FGF18‐based
protein
drugs
is
hindered
by
their
short
half‐life,
low
delivery
efficiency
need
for
repeated
articular
injections.
This
study
proposes
a
CRISPR/Cas9‐based
approach
effectively
activate
FGF18
gene
OA
chondrocytes
at
genome
level
in
vivo,
using
chondrocyte‐affinity
peptide
(CAP)
incorporated
hybrid
exosomes
(CAP/FGF18‐hyEXO)
loaded
with
an
FGF18‐targeted
gene‐editing
tool.
Furthermore,
CAP/FGF18‐hyEXO
are
encapsulated
methacrylic
anhydride‐modified
hyaluronic
(HAMA)
hydrogel
microspheres
via
microfluidics
photopolymerization
create
injectable
microgel
system
(CAP/FGF18‐hyEXO@HMs)
self‐renewable
hydration
layers
provide
persistent
lubrication
response
frictional
wear.
Together,
CAP/FGF18‐hyEXO@HMs,
combined
vivo
editing
continuous
lubrication,
have
demonstrated
capacity
synergistically
promote
cartilage
regeneration,
decrease
inflammation,
prevent
ECM
degradation
both
vitro
holding
great
potential
translation.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 3, 2024
Abstract
Exosomes
are
nanoscale
extracellular
vesicles
secreted
by
cells
and
enclosed
a
lipid
bilayer
membrane
containing
various
biologically
active
cargoes
such
as
proteins,
lipids,
nucleic
acids.
Engineered
exosomes
generated
through
genetic
modification
of
parent
show
promise
drug
delivery
vehicles,
they
have
been
demonstrated
to
great
therapeutic
potential
for
treating
cancer,
cardiovascular,
neurological,
immune
diseases,
but
systematic
knowledge
is
lacking
regarding
optimization
loading
assessment
efficacy.
This
review
summarizes
current
approaches
engineering
evaluating
their
effects,
techniques
assessing
exosome
release
kinetics,
cell
targeting,
biodistribution,
pharmacokinetics,
outcomes
critically
examined.
Additionally,
this
synthesizes
the
latest
applications
in
clinical
translation.
The
compiled
provides
framework
rational
design
rigorous
therapeutics.
Continued
advancement
robust
characterization
methods
reporting
standards
will
accelerate
development
technologies
pave
way
studies.
Graphical
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(9), С. 2236 - 2252
Опубликована: Янв. 1, 2024
Plant-derived
exosomes
(PDEs)
show
promising
potential
to
be
developed
as
a
therapeutic
agent
against
cancer,
owing
their
multiple
advantages
such
low
toxicity,
biocompatibility,
availability,
affordability,
etc.
Advanced Materials,
Год журнала:
2024,
Номер
36(41)
Опубликована: Июнь 9, 2024
Abstract
The
tumor
microenvironment
(TME)
of
typical
types
such
as
triple‐negative
breast
cancer
is
featured
by
hypoxia
and
immunosuppression
with
abundant
tumor‐associated
macrophages
(TAMs),
which
also
emerge
potential
therapeutic
targets
for
antitumor
therapy.
M1‐like
macrophage‐derived
exosomes
(M1‐Exos)
have
emerged
a
promising
candidate
their
tumor‐targeting
macrophage‐polarization
capabilities.
However,
the
limited
drug‐loading
efficiency
stability
M1‐Exos
hindered
effectiveness
in
applications.
Here,
hybrid
nanovesicle
developed
integrating
AS1411
aptamer‐conjugated
liposomes
(AApt‐Lips),
termed
M1E/AALs.
obtained
M1E/AALs
are
loaded
perfluorotributylamine
(PFTBA)
IR780,
P‐I,
to
construct
P‐I@M1E/AALs
reprogramming
TME
alleviating
engineering
TAMs.
P‐I@M1E/AAL‐mediated
therapy
enhances
situ
generation
reactive
oxygen
species,
repolarizes
TAMs
toward
an
phenotype,
promotes
infiltration
T
lymphocytes.
synergistic
based
on
significantly
suppresses
growth
prolongs
survival
4T1‐tumor‐bearing
mice.
By
multiple
treatment
modalities,
P‐I@M1E/AAL
nanoplatform
demonstrates
approach
overcoming
hypoxic
immunosuppressive
targeted
TAM
enhanced
photodynamic
immunotherapy.
This
study
highlights
innovative
TAM‐engineering
platform
tumors
characterized
TME.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 1 - 30
Опубликована: Апрель 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
