Abstract
The
clinical
application
of
oncology
therapy
is
hampered
by
high
glutathione
concentrations,
hypoxia,
and
inefficient
activation
cell
death
mechanisms
in
cancer
cells.
In
this
study,
Fe
Mo
bimetallic
sulfide
nanomaterial
(FeS
2
@MoS
)
based
on
metal‐organic
framework
structure
rationally
prepared
with
peroxidase
(POD)‐,
catalase
(CAT)‐,
superoxide
dismutase
(SOD)‐like
activities
depletion
ability,
which
can
confer
versatility
for
treating
tumors
mending
wounds.
the
lesion
area,
FeS
SOD‐like
activity
facilitate
transformation
anions
(O
−
to
hydrogen
peroxide
(H
O
),
then
resulting
H
serves
as
a
substrate
Fenton
reaction
FMS
produce
highly
toxic
hydroxyl
radicals
(
∙
OH).
Simultaneously,
has
an
ability
deplete
(GSH)
catalyze
decomposition
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
curb
regeneration
GSH
from
source.
Thus
it
realize
effective
tumor
elimination
through
synergistic
apoptosis‐ferroptosis
strategy.
Based
alteration
system,
free
radical
production,
alleviation
hypoxia
microenvironment,
NPS
not
only
significantly
inhibit
vivo
vitro,
but
also
multidrug‐resistant
bacteria
hasten
wound
healing.
It
may
open
door
development
cascade
nanoplatforms
treatment
overcoming
infection.
Abstract
With
the
changing
disease
spectrum,
atherosclerosis
has
become
increasingly
prevalent
worldwide
and
associated
diseases
have
emerged
as
leading
cause
of
death.
Due
to
their
fascinating
physical,
chemical,
biological
characteristics,
nanomaterials
are
regarded
a
promising
tool
tackle
enormous
challenges
in
medicine.
The
emerging
discipline
nanomedicine
filled
huge
application
gap
atherosclerotic
field,
ushering
new
generation
diagnosis
treatment
strategies.
Herein,
based
on
essential
pathogenic
contributors
atherogenesis,
well
distinct
composition/structural
synthesis
strategies,
surface
design
nanoplatforms,
three
major
branches
(nanodiagnosis,
nanotherapy,
nanotheranostic)
elaborated.
Then,
state‐of‐art
studies
containing
sequence
representative
significant
achievements
summarized
detail
with
an
emphasis
intrinsic
interaction/relationship
between
nanomedicines
atherosclerosis.
Particularly,
attention
is
paid
biosafety
nanomedicines,
which
aims
pave
way
for
future
clinical
translation
this
burgeoning
field.
Finally,
comprehensive
review
concluded
by
proposing
unresolved
key
scientific
issues
sharing
vision
expectation
future,
fully
elucidating
closed
loop
from
atherogenesis
paradigm
advancing
early
achievement
applications.
Molecules,
Год журнала:
2023,
Номер
28(9), С. 3916 - 3916
Опубликована: Май 5, 2023
The
development
of
new
functional
materials
based
on
metal-organic
frameworks
(MOFs)
for
adsorption
and
catalytic
applications
is
one
the
promising
trends
modern
science.
Zr-based
MOFs,
specifically
UiO-66,
are
considered
as
supports
metallic
catalysts
5-hydroxymethylfurfural
platform
molecule
reduction
into
valuable
products.
present
work
focused
effect
NH2
modification
UiO-66
its
structure
properties.
samples
were
prepared
by
a
solvothermal
method.
obtained
was
studied
X-ray
diffraction,
IR
spectroscopy,
UV-visible
low-temperature
nitrogen
adsorption.
Basic
properties
investigated
HCl
CH3COOH
adsorption,
electrokinetic
electrophoretic
light
scattering.
UiO-66-NH2
with
different
contents
aminoterephthalate
linkers
successfully
prepared.
A
gradual
decrease
in
specific
surface
area
fraction
micropores
diameter
~0.9
nm
observed
an
increase
content.
proportional
total
number
basic
sites
established
content
up
to
75%.
At
same
time,
noticeable
their
strength
higher
observed.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100767 - 100767
Опубликована: Авг. 7, 2023
Atherosclerosis
is
the
build-up
of
fatty
deposits
in
arteries.
main
underlying
cause
cardiovascular
diseases
and
leading
global
morbidity
mortality.
Current
pharmaceutical
treatment
options
are
unable
to
effectively
treat
plaque
later
stages
disease.
Instead,
they
aimed
at
resolving
risk
factors.
Nanomaterials
nanoparticle-mediated
therapies
have
become
increasingly
popular
for
atherosclerosis
due
their
targeted
controlled
release
therapeutics.
In
this
review,
we
discuss
different
types
therapeutics
used
disease
focus
on
nanomaterial
strategies
employed
delivery
these
drugs,
enabling
effective
efficient
resolution
atherosclerotic
plaque.
The
ideal
strategy
each
drug
type
(e.g.
statins,
nucleic
acids,
small
molecule
peptides)
will
be
comprehensively
discussed.
Journal of Colloid and Interface Science,
Год журнала:
2023,
Номер
646, С. 370 - 380
Опубликована: Апрель 28, 2023
In
recent
years,
small
interfering
RNA
(siRNA)
has
been
widely
used
in
the
treatment
of
human
diseases,
especially
tumors,
and
shown
great
appeal.
However,
clinical
application
siRNA
faces
several
challenges.
Insufficient
efficacy,
poor
bioavailability,
stability,
lack
responsiveness
to
a
single
therapy
are
main
problems
affecting
tumor
therapy.
Here,
we
designed
cell-penetrating
peptide
(CPP)-modified
metal
organic
framework
nanoplatform
(named
PEG-CPP33@ORI@survivin
siRNA@ZIF-90,
PEG-CPP33@NPs)
for
targeted
co-delivery
oridonin
(ORI),
natural
anti-tumor
active
ingredient)
survivin
vivo.
This
can
improve
stability
bioavailability
efficacy
monotherapy.
The
high
drug-loading
capacity
pH-sensitive
properties
zeolite
imidazolides
endowed
PEG-CPP33@NPs
with
lysosomal
escape
abilities.
Polyethylene
glycol
(PEG)-conjugated
CPP
(PEG-CPP33)
coating
significantly
improved
uptake
vitro
results
showed
that
ORI
greatly
enhanced
effect
PEG-CPP33@NPs,
demonstrating
synergistic
between
siRNA.
summary,
novel
nanobiological
platform
loaded
presented
herein
advantages
cancer
therapy,
provides
an
attractive
strategy
chemotherapy
gene
