Abstract
The
clinical
application
of
oncology
therapy
is
hampered
by
high
glutathione
concentrations,
hypoxia,
and
inefficient
activation
cell
death
mechanisms
in
cancer
cells.
In
this
study,
Fe
Mo
bimetallic
sulfide
nanomaterial
(FeS
2
@MoS
)
based
on
metal‐organic
framework
structure
rationally
prepared
with
peroxidase
(POD)‐,
catalase
(CAT)‐,
superoxide
dismutase
(SOD)‐like
activities
depletion
ability,
which
can
confer
versatility
for
treating
tumors
mending
wounds.
the
lesion
area,
FeS
SOD‐like
activity
facilitate
transformation
anions
(O
−
to
hydrogen
peroxide
(H
O
),
then
resulting
H
serves
as
a
substrate
Fenton
reaction
FMS
produce
highly
toxic
hydroxyl
radicals
(
∙
OH).
Simultaneously,
has
an
ability
deplete
(GSH)
catalyze
decomposition
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
curb
regeneration
GSH
from
source.
Thus
it
realize
effective
tumor
elimination
through
synergistic
apoptosis‐ferroptosis
strategy.
Based
alteration
system,
free
radical
production,
alleviation
hypoxia
microenvironment,
NPS
not
only
significantly
inhibit
vivo
vitro,
but
also
multidrug‐resistant
bacteria
hasten
wound
healing.
It
may
open
door
development
cascade
nanoplatforms
treatment
overcoming
infection.
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Immunogenic
cell
death
(ICD)
of
tumor
cells
serves
as
a
crucial
initial
signal
in
the
activation
anti-tumor
immune
responses,
holding
marked
promise
field
immunotherapy.
However,
low
immunogenicity
tumors
pose
challenges
achieving
complete
induction
ICD,
thereby
limiting
response
rates
immunotherapy
clinical
patients.
The
emergence
cuproptosis
new
form
regulated
has
presented
promising
strategy
for
enhanced
immunogenic
tumors.
To
trigger
cuproptosis,
copper-ionophore
elesclomol
(ES)
had
to
be
employed
copper-transporting-mediated
process.
Herein,
we
proposed
copper(II)-based
metal-organic
framework
nanoplatform
(Cu-MOF)
facilitate
cooperative
delivery
encapsulated
ES
and
copper
(ES-Cu-MOF)
induce
burst
enhance
ICD
fibrosarcoma.
Our
results
showed
that
ES-Cu-MOF
nano-regulator
could
effectively
release
Cu
2+
intracellular
environment,
resulting
elevated
mitochondrial
ROS
generation
initiated
cells.
Furthermore,
sequential
ICDs
were
significantly
triggered
via
activate
response.
inhibition
experiment
indicated
obviously
accumulated
site,
inducing
dendritic
activation.
This
enabled
an
increased
infiltration
cytotoxic
CD8
+
T
consequently
antitumor
responses
successfully
suppressing
fibrosarcoma
growth.
Thus,
offered
approach
cuproptosis-stimulated
cancer
Abstract
The
clinical
application
of
oncology
therapy
is
hampered
by
high
glutathione
concentrations,
hypoxia,
and
inefficient
activation
cell
death
mechanisms
in
cancer
cells.
In
this
study,
Fe
Mo
bimetallic
sulfide
nanomaterial
(FeS
2
@MoS
)
based
on
metal‐organic
framework
structure
rationally
prepared
with
peroxidase
(POD)‐,
catalase
(CAT)‐,
superoxide
dismutase
(SOD)‐like
activities
depletion
ability,
which
can
confer
versatility
for
treating
tumors
mending
wounds.
the
lesion
area,
FeS
SOD‐like
activity
facilitate
transformation
anions
(O
−
to
hydrogen
peroxide
(H
O
),
then
resulting
H
serves
as
a
substrate
Fenton
reaction
FMS
produce
highly
toxic
hydroxyl
radicals
(
∙
OH).
Simultaneously,
has
an
ability
deplete
(GSH)
catalyze
decomposition
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
curb
regeneration
GSH
from
source.
Thus
it
realize
effective
tumor
elimination
through
synergistic
apoptosis‐ferroptosis
strategy.
Based
alteration
system,
free
radical
production,
alleviation
hypoxia
microenvironment,
NPS
not
only
significantly
inhibit
vivo
vitro,
but
also
multidrug‐resistant
bacteria
hasten
wound
healing.
It
may
open
door
development
cascade
nanoplatforms
treatment
overcoming
infection.
