Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(30)
Опубликована: Авг. 11, 2024
Ferrous
ion
accumulation
and
lethal
oxidative
stress
mediate
irreversible
retinal
pigment
epithelial
(RPE)
cell
ferroptosis
subsequent
photoreceptor
degeneration,
a
potential
key
pathogenic
factor
in
the
onset
of
dry
age-related
macular
degeneration
(dAMD),
causing
vision
loss
global
elderly
population.
However,
currently,
no
effective
interventional
treatment
strategy
exists
clinical
practice.
Herein,
lesion
site-targeted
melanin-like
nanoparticles,
named
ConA-MelNPs,
are
designed
as
novel
inhibitor
for
degenerative
diseases.
ConA-MelNPs
possessed
chelating
iron
characteristics,
alleviating
severe
mitochondrial
damage
caused
by
protecting
RPE
cells
from
induced
sodium
iodate
(NaIO
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Фев. 21, 2025
Abstract
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
a
promising
therapeutic
strategy
in
regenerative
medicine,
demonstrating
significant
potential
for
clinical
applications.
Evidence
suggests
that
MSCs
not
only
exhibit
multipotent
differentiation
but
also
exert
critical
effects
retinal
degenerative
diseases
via
robust
paracrine
mechanisms.
protect
from
damage
by
modulating
inflammation,
inhibiting
apoptosis,
alleviating
oxidative
stress,
and
suppressing
cell
death
pathways.
Furthermore,
contribute
to
structural
functional
stability
facilitating
vascular
remodeling
donating
mitochondria
cells.
Of
particular
interest,
MSC-derived
exosomes
gained
widespread
attention
compelling
cell-free
therapy.
Owing
their
potent
anti-inflammatory,
anti-apoptotic,
vascular-stabilizing
properties,
show
promise
the
treatment
of
diseases.
ACS Nano,
Год журнала:
2024,
Номер
18(34), С. 22793 - 22828
Опубликована: Авг. 14, 2024
Extracellular
vesicles
(EVs)
are
nanoscale
membrane
of
various
sizes
that
can
be
secreted
by
most
cells.
EVs
contain
a
diverse
array
cargo,
including
RNAs,
lipids,
proteins,
and
other
molecules
with
functions
intercellular
communication,
immune
modulation,
regulation
physiological
pathological
processes.
The
biofluids
in
the
eye,
tears,
aqueous
humor,
vitreous
important
sources
for
EV-based
diagnosis
ocular
disease.
Because
molecular
cargos
may
reflect
biology
their
parental
cells,
these
biofluids,
as
well
blood,
have
been
recognized
promising
candidates
biomarkers
early
Moreover,
also
used
therapeutics
targeted
drug
delivery
nanocarriers
many
disorders
because
low
immunogenicity
superior
biocompatibility
nature.
In
this
review,
we
provide
an
overview
recent
advances
field
studies
on
We
summarized
origins
applied
disease,
assessed
different
methods
EV
isolation
from
biofluid
samples,
highlighted
bioengineering
strategies
systems,
introduced
latest
applications
treatment
presented
potential
current
clinical
trials.
Finally,
briefly
discussed
challenges
disease
some
issues
concern
better
focusing
translational
future.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Фев. 8, 2024
Vascular
dementia
(VD)
is
a
prevalent
cognitive
disorder
among
the
elderly.
Its
pathological
mechanism
encompasses
neuronal
damage,
synaptic
dysfunction,
vascular
abnormalities,
neuroinflammation,
and
oxidative
stress,
others.
In
recent
years,
extracellular
vesicles
(EVs)
derived
from
mesenchymal
stem
cells
(MSCs)
have
garnered
significant
attention
as
an
emerging
therapeutic
strategy.
Current
research
indicates
that
MSC-derived
(MSC-EVs)
play
pivotal
role
in
both
diagnosis
treatment
of
VD.
Thus,
this
article
delves
into
advancements
MSC-EVs
VD,
discussing
mechanisms
by
which
EVs
influence
pathophysiological
processes
These
form
theoretical
foundation
for
their
neuroprotective
effect
VD
treatment.
Additionally,
highlights
potential
applications
diagnosis.
conclusion,
present
promising
innovative
strategy
With
rigorous
ongoing
innovation,
concept
can
transition
practical
clinical
treatment,
providing
more
effective
options
patients.
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1647 - 1647
Опубликована: Окт. 8, 2024
The
most
prevalent
reason
for
vision
impairment
in
aging
inhabitants
is
age-related
macular
degeneration
(AMD),
a
posterior
ocular
disease
with
poor
understanding
of
the
anatomic,
genetic,
and
pathophysiological
progression
disease.
Recently,
new
insights
exploring
role
atrophic
changes
retinal
pigment
epithelium,
extracellular
drusen
deposits,
lysosomal
lipofuscin,
various
genes
have
been
investigated
AMD.
Hence,
this
review
explores
incidence
risk
factors
AMD,
such
as
oxidative
stress,
inflammation,
complement
system,
involvement
bioactive
lipids
their
angiogenesis.
In
addition
to
intravitreal
anti-vascular
endothelial
growth
factor
(VEGF)
therapy
other
therapeutic
interventions
oral
kinase
inhibitors,
photodynamic,
gene,
antioxidant
therapy,
well
benefits
drawbacks
AMD
treatment
options,
strategic
drug
delivery
methods,
including
routes
focus
on
pharmacokinetics,
are
investigated.
Further,
recent
advancements
nanoformulations
polymeric
lipid
nanocarriers,
liposomes,
etc.,
intended
pros
cons
too
summarized.
Therefore,
purpose
give
researchers
an
pathophysiology,
emphasis
angiogenesis,
function
lipids,
options.
Additionally,
options
that
development
system(s)
via
several
can
aid
advancement
choices.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 16, 2024
Stem
cell
therapy
constitutes
a
pivotal
subject
in
contemporary
discourse,
with
donor
stem
cells
having
been
employed
research
and
clinical
treatments
for
several
decades.
Primary
transplantation
encompasses
diverse
types,
including
ectomesenchymal
cells,
hematopoietic
various
derivatives
such
as
vesicles
extracellular
vesicles.
Nevertheless,
the
emergence
of
engineering
techniques
has
heralded
new
epoch
therapy,
markedly
broadening
their
therapeutic
potential.
Induced
pluripotent
(iPSCs)
epitomize
significant
milestone
modern
medical
biology.
This
groundbreaking
discovery
offers
potential
disciplines
biology,
pathophysiology,
cellular
regenerative
medicine.
As
result,
iPSCs
derived
differentiated
have
become
pioneering
avenue
research.
mesenchymal
(iMSCs),
from
iPSCs,
represent
novel
frontier
MSCs
related
Empirical
evidence
suggests
that
iMSCs
demonstrate
enhanced
proliferative
capacities
compared
to
natural
MSCs,
diminished
age-related
variability
heterogeneity.
Numerous
trials
highlighted
prospective
superiority
iMSCs.
article
synthesizes
current
basic
pertaining
iMSCs,
aiming
provide
reference
point
future
endeavors.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Май 18, 2023
Mesenchymal
stem
cells
(MSCs)
from
multiple
tissues
have
the
capability
of
multidirectional
differentiation
and
self-renewal.
Many
reports
indicated
that
MSCs
exert
curative
effects
on
a
variety
age-related
diseases
through
regeneration
repair
aging
organs.
However,
as
research
has
progressed,
it
become
clear
is
derived
exosomes
(MSC-Exos)
may
real
role
to
play,
they
can
be
modified
achieve
better
therapeutic
results,
making
them
even
more
advantageous
than
for
treating
disease.
This
review
generalizes
biological
characteristics
their
mechanisms
in
diseases,
example,
treat
such
oxidative
stress
(OS),
Wnt/β-catenin
signaling
pathway,
mitogen-activated
protein
kinases
(MAPK)
so
on.
In
addition,
current
vivo
vitro
trials
are
described,
ongoing
clinical
discussed,
well
prospects
challenges
future
use
disease
treatment.
will
provide
references
using
diseases.
