An AIE-Based Theranostic Nanoplatform for Enhanced Colorectal Cancer Therapy: Real-Time Tumor-Tracking and Chemical-Enhanced Photodynamic Therapy DOI
Jiaqi Feng, Xiang Tian,

Ruige Cao

и другие.

Опубликована: Янв. 1, 2023

The combination of diagnostic and therapeutic agents in the form theranostic platforms is receiving increasing attention to enhance tumor efficacy. However, traditional systems relying on simultaneous encapsulation, embedding or conjugation various onto nanocarriers always require intricate synthetic process. Herein, a supramolecular drug-drug self-delivery nanosystem (DSDN) based newly developed aggregation-induced emission (AIE) photosensitizer (CBTM) an anti-tumor tyroservaltide (YSV) was constructed integrate near-infrared (NIR) fluorescence, photodynamic, chemotherapeutic effects. Transmission electron microscopy (TEM) dynamic light scattering (DLS) confirmed that YSV CBTM could co-assemble into YSV/CBTM nanoparticles via π-π stacking hydrogen bonding, with regular round-shape morphology homogeneous size. Inspiringly, entered CT26 cells high NIR fluorescence emission, allowing preoperative diagnosis. Meanwhile, as-prepared efficiently produce reactive oxygen species (ROS) under irradiation for effective photodynamic ablation cells. More importantly, peptide drug not only improve availability CBTM, but also serve as toxic adjuvant therapy (PDT) efficacy CBTM. Thereafter, most tumors were thoroughly ablated by combining PDT chemotherapy (CT) maximal killing colorectal tissues. Regarding advantages nanosystem, we believe this strategy significantly potentiate survival cancer mice maximizing efficacy, offer prospective insights advanced applications.

Язык: Английский

A short appraisal of polylactic-co-glycolic acid based polymer nanotechnology for colon cancer: recent advances and literature evidences DOI
Abhinav Vashishat,

Amrinder Singh,

Balak Das Kurmi

и другие.

Therapeutic Delivery, Год журнала: 2023, Номер 14(7), С. 459 - 472

Опубликована: Июль 1, 2023

The currently available formulations provided non-targeted treatment of colon cancer, the deadliest cancer variant. Due to biopharmaceutical hindrances, majority drugs are unable reach target site. Polylactic-co-glycolic acid (PLGA) is one versatile polymers in treatment, diagnostics and theranostics. unique mechanism surface modifications PLGA properties has been a keen interest be used different nanoparticles for improving attributes. ongoing use these smart nano-carriers allowed targeted delivery several active components on wide scale. main goal this review compile information PLGA-based nanocarriers which possess desirable drug applications, including biocompatibility, biodegradability tunable drug-release kinetics.

Язык: Английский

Процитировано

3
Mechanisms of Chemoresistance in High-Grade Gliomas DOI

Masoud Sohrabi Asl,

Arad Iranmehr, Sara Hanaei

и другие.

Interdisciplinary cancer research, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

1
An AIE-Based Theranostic Nanoplatform for Enhanced Colorectal Cancer Therapy: Real-Time Tumor-Tracking and Chemical-Enhanced Photodynamic Therapy DOI
Jiaqi Feng, Xiang Tian,

Ruige Cao

и другие.

Опубликована: Янв. 1, 2023

The combination of diagnostic and therapeutic agents in the form theranostic platforms is receiving increasing attention to enhance tumor efficacy. However, traditional systems relying on simultaneous encapsulation, embedding or conjugation various onto nanocarriers always require intricate synthetic process. Herein, a supramolecular drug-drug self-delivery nanosystem (DSDN) based newly developed aggregation-induced emission (AIE) photosensitizer (CBTM) an anti-tumor tyroservaltide (YSV) was constructed integrate near-infrared (NIR) fluorescence, photodynamic, chemotherapeutic effects. Transmission electron microscopy (TEM) dynamic light scattering (DLS) confirmed that YSV CBTM could co-assemble into YSV/CBTM nanoparticles via π-π stacking hydrogen bonding, with regular round-shape morphology homogeneous size. Inspiringly, entered CT26 cells high NIR fluorescence emission, allowing preoperative diagnosis. Meanwhile, as-prepared efficiently produce reactive oxygen species (ROS) under irradiation for effective photodynamic ablation cells. More importantly, peptide drug not only improve availability CBTM, but also serve as toxic adjuvant therapy (PDT) efficacy CBTM. Thereafter, most tumors were thoroughly ablated by combining PDT chemotherapy (CT) maximal killing colorectal tissues. Regarding advantages nanosystem, we believe this strategy significantly potentiate survival cancer mice maximizing efficacy, offer prospective insights advanced applications.

Язык: Английский

Процитировано

0