Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles to Treat PCOS

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 11151 - 11151

Опубликована: Июль 6, 2023

Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in women. Previously, we suggested that human mesenchymal stem cells (MSCs) can reverse PCOS condition by secreting factors. Here, evaluated therapeutic capability of MSC-derived extracellular vesicles (EVs), also exosomes, both vitro and vivo models. Exosomes were used to treat androgen-producing H293R injected a mouse model through intraovarian intravenous injection into letrozole (LTZ)-induced model. We assessed effects exosomes on or analyzing steroidogenic gene expression (quantitative real-time polymerase chain reaction (qRT-PCR)), body weight change, serum hormone levels, fertility pup delivery. Our data show effect EVs for reversing conditions, including issues. Interestingly, was more effective glucose regulation, an restoration. study suggests be promising biopharmaceutics treating conditions novel option. Despite fact need validation patients, may evaluate this treatment option with following clinical trials.

Язык: Английский

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Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(26), С. 6285 - 6304

Опубликована: Янв. 1, 2024

Phototherapy, including photothermal therapy (PTT) and photodynamic (PDT), has the advantages of spatiotemporal selectivity, non-invasiveness, negligible drug resistance. Phototherapy been approved for treating superficial epidermal tumors. However, its therapeutic efficacy is limited by hypoxic tumor microenvironment highly expressed heat shock protein. Moreover, poor tissue penetration focused irradiation laser region in phototherapy make deep tissues metastatic tumors challenging. Combination strategies, which integrate each treatment overcome their disadvantages, can significantly improve efficacy. Recently, many combination strategies have reported. Our study summarizes used combining with other cancer treatments such as chemotherapy, immunotherapy, sonodynamic therapy, gas starvation chemodynamic therapy. Some research cases were selected to analyze effect, delivery platform feature, synergetic anticancer mechanisms. additional are summarized tables. This review provides strong evidence that phototherapy-based enhance effect compared alone. Additionally, challenges future perspectives associated these combinational therapies discussed.

Язык: Английский

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5-Fluorouracil in Combination with Calcium Carbonate Nanoparticles Loaded with Antioxidant Thymoquinone against Colon Cancer: Synergistically Therapeutic Potential and Underlying Molecular Mechanism

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1030 - 1030

Опубликована: Авг. 25, 2024

Colon cancer is the third most common worldwide, with high mortality. Adverse side effects and chemoresistance of first-line chemotherapy 5-fluorouracil (5-FU) have promoted widespread use combination therapies. Thymoquinone (TQ) a natural compound potent antioxidant activity. Loading antioxidants into nano delivery systems has been major advance in enhancing their bioavailability to improve clinical application. Hence, this study aimed prepare optimal TQ-loaded calcium carbonate nanoparticles (TQ-CaCO3 NPs) investigate therapeutic potential underlying molecular mechanisms TQ-CaCO3 NPs 5-FU against colon cancer. Firstly, we developed purely aragonite CaCO3 facile mechanical ball-milling method. The pH-sensitive biocompatible sustained release properties were prepared using synthesized method (a high-speed homogenizer). vitro revealed that (15 μM) (7.5 inhibited CT26 cell proliferation migration, induced apoptosis cycle arrest G0/G1 phase, suppressed spheroid growth, exhibiting synergistic effect. Finally, network pharmacology docking results indicated targets crucial signaling pathways Therefore, combined could enhance anti-colon broader targets, warranting further application for treatment.

Язык: Английский

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Aptamer-functionalized liposomes for drug delivery

Biomedical Journal, Год журнала: 2023, Номер 47(4), С. 100685 - 100685

Опубликована: Дек. 10, 2023

Among the various targeting ligands for drug delivery, aptamers have attracted much interest in recent years because of their smaller size compared to antibodies, ease modification, and better batch-to-batch consistency. In addition, can be selected target both known even unknown cell surface biomarkers. For loading, liposomes are most successful vehicle many FDA-approved formulations based on liposomes. this paper, aptamer-functionalized targeted delivery reviewed. We begin with description related selection, followed by methods conjugate fate such conjugates vivo. Then a few examples applications addition intravenous injection systemic hoping achieve accumulation at sites, certain applications, it is also possible aptamer/liposome applied directly tissue as intratumor dropping eye adhering cornea. While previous reviews focused cancer therapy, current review mainly covers other last four years. Finally, article discusses potential issues aptamer some future research opportunities.

Язык: Английский

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Calcium-based nanomaterials for cancer therapy

Journal of Materials Science, Год журнала: 2024, Номер 59(24), С. 10650 - 10676

Опубликована: Июнь 1, 2024

Язык: Английский

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Preparation of ternary hybridized chitosan microspheres with photothermal effect for pH-sensitive long-lasting controlled release system and its release mechanism

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 135755 - 135755

Опубликована: Окт. 17, 2024

Язык: Английский

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Preparation of pH-Sensitive Astragalus Polysaccharide Nanoparticles Loaded with Paclitaxel and Evaluation of Antitumor Activity

Journal of Pharmaceutical Innovation, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 23, 2025

Язык: Английский

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Targeted delivery of neratinib/xanthan gum-capped calcium carbonate nanoparticles induces apoptosis through PI3K/AKT pathway in breast cancer mice model

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142963 - 142963

Опубликована: Апрель 1, 2025

Язык: Английский

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Intranasal pterostilbene nanoparticles delivery alleviates neuroinflammation and brain injury after intracerebral hemorrhage

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111248 - 111248

Опубликована: Апрель 1, 2025

Язык: Английский

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Near-Infrared Titania Nanoparticle-Based Photoimmunotherapy via Tumor-Microenvironment-Responsive Gene Editing of SerpinB9 for Triple-Negative Breast Cancer

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(3), С. 3059 - 3070

Опубликована: Янв. 18, 2024

Triple-negative breast cancer (TNBC) is a heterogeneous disease with multiple biological subtypes, offering poor clinical outcomes. No targeted therapy was approved for TNBC due to lack of tumor-specific targets. Here, we identify SerpinB9 as vulnerability target immunomodulatory tumors, suggesting that gene editing via the CRISPR/Cas9 system may be viable approach TNBC-targeted therapy. To increase bioavailability and improve delivery efficiency editing, designed glutathione-responsive nanoparticles deliver Cas9 ribonucleoprotein targeting (TiO2–x@Cas9-RNP@HA). Under near-infrared light irradiation, TiO2–x can produce both photodynamic (PDT) photothermal (PTT) effects. PTT induce tumor cell ablation immunogenic death. PDT ROS killing downregulation SerpinB9. Inhibition expression (TiO2–x@Cas9-RNP@HA) combined titania phototherapy synergistically inhibit growth. These results demonstrate potential nanoparticle-based precise SerpinB9-targeted therapies in TNBCs.

Язык: Английский

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