Bacteria-based drug delivery for treating non-oncological diseases

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 668 - 683

Опубликована: Янв. 18, 2024

Язык: Английский

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A deep insight into ferroptosis in lung disease: facts and perspectives

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Март 18, 2024

In the last decade, ferroptosis has received much attention from scientific research community. It differs other modes of cell death at morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent caused lipid peroxide excess accompanied abnormal iron metabolism oxidative stress. recent years, more studies have shown that closely related to occurrence development lung diseases. COPD, asthma, injury, fibrosis, cancer, infection respiratory diseases become third most common chronic worldwide, bringing serious economic psychological burden people around world. However, exact mechanism which involved in progression not been fully revealed. this manuscript, we describe ferroptosis, targeting signaling pathways proteins, summarize relationship between diseases, explore intervention targeted therapy for

Язык: Английский

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Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model

International Immunopharmacology, Год журнала: 2023, Номер 124, С. 111063 - 111063

Опубликована: Окт. 17, 2023

Sepsis-induced lung injury is an acute hypoxic respiratory insufficiency caused by systemic infectious factors that results in alveolar epithelial cell and capillary endothelial injury, diffuse pulmonary interstitial edema, edema. Heme oxygenase (HO)-1 usually associated with inflammation has anti-inflammatory effects. Autophagy a degradation pathway eliminates cellular metabolic waste plays important protective role during stress. The phosphatidylinositol 3-kinase/ protein kinase B (PI3K/Akt) signaling key mediating responses to inflammatory reactions. Therefore, we hypothesized HO-1 autophagy regulated the PI3K/Akt mice sepsis-induced injury. was induced using cecal ligation puncture (CLP). Hemin or Sn-protoporphyrin IX (SnPP) administered via intraperitoneal injection before surgery. Survival rates were observed days 1-7 after surgery; histology discerned 24 h pro-inflammatory plasma tissue measured enzyme-linked immunosorbent assay (ELISA); HO-1, Beclin-1, microtubule-associated 1 light chain 3B (LC3B)-II, p62 lysosome membrane (LAMP)2 expression levels LC3B-II immunofluorescence autophagosomes detected electron microscopy Furthermore, when PI3K inhibitors LY294002, activators Recilisib hemin surgery, Akt, p-Akt, LC3-II post-surgery. We found overexpression increased survival rate inhibited attenuated of proinflammatory cytokines (TNF-α, IL-1β) cytokine (IL-10, HO-1) overexpression. Moreover, also LAMP2 expression; decreased significantly autophagosome formation. for HO-1-downregulated contrasted those mentioned above. LY294002 p-Akt/Akt, reversed inhibitory effect LY294002. involved mediation autophagy, which may be mice.

Язык: Английский

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Advances in DNA nanotechnology for chronic wound management: Innovative functional nucleic acid nanostructures for overcoming key challenges

Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 155 - 177

Опубликована: Сен. 8, 2024

Язык: Английский

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Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 109914 - 109914

Опубликована: Апрель 1, 2024

Язык: Английский

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Advances in Nanoparticles in Targeted Drug Delivery- A Review

Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100529 - 100529

Опубликована: Апрель 1, 2025

Язык: Английский

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Construct nucleic acid delivery carriers with excellent antibacterial capabilities for the treatment of bacterial MRSA-induced lung inflammation

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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Carrier Free 1,2,3,4,6-O-Pentagalloylglucose Nanoparticles for Treatment of Acute Lung Injury

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Acute lung injury (ALI) is a severe disease with high mortality rate, and novel therapeutic strategies must be developed crucially. The amelioration of inflammation oxidative stress promising strategy for alleviating ALI. 1,2,3,4,6-O-pentagalloylglucose (PGG) has pronounced effect on ALI, excellent anti-inflammatory antioxidant effects. However, poor solubility low bioavailability have affected its clinical application. In this study, carrier-free PGG nanoparticles (PGG NPs) were prepared by antisolvent precipitation method. NPs been engineered to improve solubility, sustained release behavior, higher than free PGG. Moreover, the pharmacodynamic results showed that remarkable protective ALI in rats better PGG, which related activation Nrf2/Keap1/HO-1/NLRP3 pathway. Overall, study not only demonstrates efficacy safety against but also holds promise as nanodrug system.

Язык: Английский

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Insight into Steroid-Induced ONFH: The Molecular Mechanism and Function of Epigenetic Modification in Mesenchymal Stem Cells

Biomolecules, Год журнала: 2023, Номер 14(1), С. 4 - 4

Опубликована: Дек. 20, 2023

Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which one causes hip pain and dysfunction. ONFH has very high disability rate, associated with heavy burden to patients, families, society. The pathogenesis not completely clear. At present, it believed that mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance osteogenic/adipogenic differentiation, poor vascularization repair. prevention treatment always been great challenge for clinical surgeons. However, recent studies have emphasized use mesenchymal stem cells (MSCs) treat steroid-induced (SONFH) promising therapy. This review focuses on role molecular mechanism epigenetic regulation in progress MSCs SONFH, discusses significance latest research SONFH from perspective epigenetics.

Язык: Английский

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Nucleic acid-based nanotherapeutics for treating sepsis and associated organ injuries

Theranostics, Год журнала: 2024, Номер 14(11), С. 4411 - 4437

Опубликована: Янв. 1, 2024

In recent years, gene therapy has been made possible with the success of nucleic acid drugs against sepsis and its related organ dysfunction.Therapeutics based on acids such as small interfering RNAs (siRNAs), microRNAs (miRNAs), messenger (mRNAs), plasmid DNAs (pDNAs) guarantee to treat previously undruggable diseases.The advantage acid-based lies in development nanocarriers, achieving targeted controlled delivery for improved efficacy minimal adverse effects.Entrapment into nanocarriers also ameliorates poor cellular uptake naked acids.In this study, we discuss current state art nanoparticles hyperinflammation apoptosis associated sepsis.The optimized design through physicochemical property modification ligand conjugation can target specific organs-such lung, heart, kidney, liver-to mitigate multiple sepsis-associated injuries.This review highlights nanomaterials designed fabricating anti-sepsis nanosystems, their characterization, mechanisms working sepsis, potential promoting therapeutic efficiency acids.The investigations nanoparticulate application management are summarized paper.Noteworthily, nanotherapeutic allows a novel strategy sepsis.Further clinical studies required confirm findings cell-and animal-based experiments.The capability large-scale production reproducibility nanoparticle products critical commercialization.It is expected that numerous possibilities will be investigated nanotherapeutics future.

Язык: Английский

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