Journal of Cardiothoracic Surgery, Год журнала: 2024, Номер 19(1)
Опубликована: Окт. 1, 2024
Язык: Английский
International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 3975 - 3986
Опубликована: Сен. 1, 2024
Despite technological advances in science and medicine, acute lung injury (ALI) is still associated with high mortality rates the ICU. Therefore, finding novel drugs treatment approaches crucial to preventing ALI. Drug repurposing a common practice clinical research, primarily for that have previously received approval use patients, investigate uses of therapies. One such medication edaravone, which highly effective free-radical scavenger also has anti-inflammatory, anti-apoptotic, antioxidant, anti-fibrotic effects. Both basic studies shown edaravone can treat different types through its distinct properties. Edaravone exhibits significant protective benefits holds promising potential ALI caused by diverse factors, thereby offering approach treating This study aims provide new insights options reviewing both research on edaravone. The focus evaluating effectiveness various factors.
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 268 - 268
Опубликована: Фев. 20, 2024
Sepsis-induced ALI is marked by physiological, pathological, and biochemical irregularities caused infection. Growth differentiation factor 3 (GDF3) closely associated with the inflammatory response. Accumulating evidence has demonstrated a close relationship between GDF3 expression severity prognosis of sepsis. However, precise mechanism which protects against induced sepsis still unclear. Following intravenous administration in this research, we noted rise survival rate, decrease histopathological damage as evaluated through HE staining, decline count cells bronchoalveolar lavage fluid (BALF), reduction ratio lung wet/dry (W/D) weight, noteworthy levels pro-inflammatory cytokines both serum BALF when compared to septic mice who underwent cecal ligation puncture (CLP). These collective findings unequivocally indicate protective effects sepsis-induced ALI. In addition, group showed significant mRNA Caspase-1 NLRP3 CLP group. this, performed vitro tests confirm these discoveries obtained comparable outcomes, wherein notably decreased protein macrophages comparison LPS Furthermore, exhibited capacity reduce secretion molecules from macrophages. By illuminating GDF regulates macrophages, offers theoretical basis for preventing treating
Язык: Английский
Процитировано
1
Regenerative Biomaterials, Год журнала: 2024, Номер 11
Опубликована: Янв. 1, 2024
Abstract Acute lung injury (ALI) is a devastating inflammatory disease. MicroRNA155 (miR155) in alveolar macrophages and epithelial cells enhances reactions by inhibiting the suppressor of cytokine signaling 1 (SOCS1) ALI. Anti-miR155 oligonucleotide (AMO155) have been suggested as potential therapeutic reagent for However, safe efficient carrier required delivery AMO155 into lungs ALI therapy. In this study, cell membrane-derived nanovesicles (CMNVs) were produced from membranes LA4 mouse evaluated lungs. For preparation CMNVs, isolated CMNVs extrusion. Cholesterol-conjugated (AMO155c) was loaded extracellular vesicles (EVs) sonication. The physical characterization indicated that with AMO155c (AMO155c/CMNV) membrane-structured size ∼120 nm. efficiency efficacy compared those EVs or polyethylenimine (25 kDa, PEI25k). similar to EVs. As result, miR155 levels reduced AMO155c/CMNV AMO155c/EV. administered intratracheally models. SOCS1 increased more efficiently than others, suggesting effectively inhibited AMO155c/CMNV. addition, cytokines they AMO155c/EV AMO155c/PEI25k, reducing inflammation reactions. results suggest are useful treatment
Язык: Английский
Процитировано
1
European Journal of Pharmacology, Год журнала: 2024, Номер 984, С. 177034 - 177034
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
1
Biomaterials Research, Год журнала: 2024, Номер 28
Опубликована: Янв. 1, 2024
Acute lung injury (ALI) is a devastating inflammatory disease. In lungs with inflammation, microRNA155 (miR155) induces cytokines by inhibiting the expression of suppressor cytokine signaling-1 (SOCS1). addition, glycyrrhizic acid (GA) has been suggested as an anti-inflammatory drug for ALI, since it efficient inhibitor nuclear factor-κB. this study, combined delivery system anti-miR155 oligonucleotides (AMO155) and GA was developed R3V6 treatment ALI. R3V6s formed comicelles cholesterol-conjugated AMO155 (AMO155c) charge hydrophobic interactions. GA, amphiphilic drug, integrated to AMO155c-R3V6 micelles, producing AMO155c-R3V6-GA ternary micelles. The size smaller than that AMO155c-R3V6, suggesting integration reduced micelles effectively. had higher efficiency comparison AMO155-R3V6-GA AMO155c-R3V6-GA, cholesterol moiety AMO155c increased stability For in vivo evaluation, nebulized micelle solution were administrated into ALI animal models intratracheally. improved efficiency, compared AMO155c-polyethylenimine complex lungs. As result, SOCS1 increased, proinflammatory groups, other groups. conclusion, may be useful therapy
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 1 - 11
Опубликована: Окт. 21, 2023
Exacerbated inflammatory responses can be detrimental and pose fatal threats to the host, as exemplified by global impact of COVID-19 pandemic, resulting in millions fatalities. Developing novel drugs combat damaging effects inflammation is essential for both preventive measures therapeutic interventions. Accumulating evidence suggests that Angiotensin Converting Enzyme 2 (ACE2) possesses ability optimize responses. However, clinical applicability this potential limited due lack dependable ACE2 activators. In study, we conducted a screening an FDA-approved drug library successfully identified activator, termed H4. The activator demonstrated capability mitigate lung caused bacterial infections, effectively modulating neutrophil infiltration. Importantly, improve poorly water-soluble H4, developed prodrug variant with significantly enhanced water solubility while maintaining similar level efficacy H4 attenuating lungs mice exposed infections. This finding highlights formulated promising candidate treatment prevention diseases, including lung-related conditions.
Язык: Английский
Процитировано
2
Bioorganic Chemistry, Год журнала: 2024, Номер 147, С. 107396 - 107396
Опубликована: Апрель 30, 2024
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116456 - 116456
Опубликована: Март 28, 2024
Acute lung injury (ALI) is a common and critical respiratory disorder caused by various factors, with viral infection being the leading contributor. Dehydroandrographolide (DAP), constituent of Chinese herbal plant Andrographis paniculata, exhibits range activities including anti-inflammatory, in vitro antiviral immune-enhancing effects. This study evaluated anti-inflammatory effects pharmacokinetics (PK) profile DAP ALI mice induced intratracheal instillation Poly(I:C) (PIC). The results showed that oral administration (10–40 mg/kg) effectively suppressed increase wet–dry weight ratio, total cells, protein content, accumulation immune inflammatory cytokines neutrophil elastase levels bronchoalveolar lavage fluid PIC-treated mice. concentrations, determined an LC-MS/MS method, plasma after receiving (20 were unchanged compared to those normal However, concentrations relative PK parameters lungs significantly altered mice, exhibiting relatively higher maximum concentration, larger AUC, longer elimination half-life than These demonstrated could improve edema inflammation suggested might influence properties DAP, increased distribution residence. Our provides evidence displays significant activity against more likely distribute damaged tissue.
Язык: Английский
Процитировано
0
Immunologic Research, Год журнала: 2024, Номер 72(4), С. 683 - 696
Опубликована: Апрель 27, 2024
Язык: Английский
Процитировано
0
Journal of Cardiothoracic Surgery, Год журнала: 2024, Номер 19(1)
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0