Peroxidase‐Mimicking Iron‐Based Single‐Atom Upconversion Photocatalyst for Enhancing Chemodynamic Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(34)

Опубликована: Май 27, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a novel approach to overcome cancer resistance and enhance anticancer efficacy. Despite the considerable effort devoted current chemodynamic therapeutic agents, developing efficient delivery systems induce ferroptosis remains demanding due their limited efficacy lack of selectivity. Herein, an iron‐based single‐atom upconversion photocatalyst (UmFe‐OA@hPM) mimicking natural horseradish peroxidases been developed. This nanoformulation not only targets tumors via existence hybrid platelet membrane (hPM) coating but also generates excessive hydroxyl radicals in response both tumor microenvironment external laser irradiation. nanoenzyme overcomes low tissue penetration UV light, which sensitizes iron‐doped graphitic carbon nitride network, attributed unique anti‐Stokes shift from infrared displayed by nanoparticles. Together with increase intracellular polyunsaturated fatty acid accumulation induced oleanolic (OA), lipid peroxidation is significantly elevated, leading enhancement CDT. UmFe‐OA@hPM demonstrated significant vitro, superior antitumor breast mouse models, suppression metastasis status when incorporated immune checkpoint blockade. These findings provide potential strategy for precisely controlled CDT deal aggressive cancers, especially combination immunotherapy.

Язык: Английский

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Nanomedicines Targeting Tumor Cells or Tumor-Associated Macrophages for Combinatorial Cancer Photodynamic Therapy and Immunotherapy: Strategies and Influencing Factors

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 10129 - 10144

Опубликована: Окт. 1, 2024

Immunotherapy is a promising cancer treatment because of its ability to sustainably enhance the natural immune response. However, effects multiple immunotherapies, including ICIs, are limited by resistance these agents, immune-related adverse events, and lack reasonable therapeutic targets available at right time place. The tumor microenvironment (TME), which features tumor-associated macrophages (TAMs), plays significant role in owing hypoxic blood vessels, resulting evasion. To immunotherapy, photodynamic therapy (PDT) can increase innate adaptive responses through immunogenic cell death (ICD) improve TME. Traditional photosensitizers (PSs) also include novel nanomedicines precisely target cells or TAMs. Here, we reviewed summarized current strategies possible influencing factors for photoimmunotherapy.

Язык: Английский

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Nanoparticle-mediated enhancement of DNA Vaccines: Revolutionizing immunization strategies

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140558 - 140558

Опубликована: Фев. 1, 2025

Язык: Английский

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Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out reach. This is predominantly fundamental issues at preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, insufficient validation nanothermometer performance physiological environments. The main impediments currently are important biophysicochemical that must addressed comprehensively, first foremost available vitro systems, before going on vivo investigations. review outlines critical perspective, well route suggestions underexplored aspects address significantly minimize existing translational gap.

Язык: Английский

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Tumor Treatment by Nano-Photodynamic Agents Embedded in Immune Cell Membrane-Derived Vesicles

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 481 - 481

Опубликована: Апрель 7, 2025

Non-invasive phototherapy includes modalities such as photodynamic therapy (PDT) and photothermal (PTT). When combined with tumor immunotherapy, these therapeutic approaches have demonstrated significant efficacy in treating advanced malignancies, thus attracting considerable attention from the scientific community. However, progress of therapies is hindered by inherent limitations potential adverse effects. Recent findings indicate that certain strategies, including phototherapy, can induce immunogenic cell death (ICD), thereby opening new avenues for integration immunotherapy. Currently, development biofilm nanomaterial-encapsulated drug delivery systems has reached a mature stage. Immune membrane-encapsulated nano-photosensitizers hold great promise, they enhance immune microenvironment. Based on bioengineering technology, membranes be designed according to microenvironment, enhancing targeting properties nano-photosensitizers. Additionally, space provided membrane allows co-encapsulation immunotherapeutic agents chemotherapy drugs, achieving synergistic effect. At same time, timing precisely controlled regulate action both drugs. This article summarizes analyzes current research based aforementioned advancements.

Язык: Английский

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Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines as Targeting Ligands

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

Tumor-associated macrophages (TAMs) are highly plastic tumor-infiltrating immune cells. Their reprogramming has emerged as a pivotal strategy in antitumor immunotherapy. The TLR7/8 agonist, IMDQ, significant potential for but lacks target specificity. To address this challenge, we developed novel folate receptor beta (FR-β) targeting chimeric molecules using 6-substituted pyrrolo[2,3-d]pyrimidines high-affinity ligands, which demonstrate superior FR-β capability compared with classical folic acid. These integrate the moiety marking first application of immunomodulator targeted constructs. In vitro and vivo studies demonstrated that our selectively reprogrammed TAMs toward an immunostimulatory phenotype, reshaped tumor microenvironment, inhibited progression without systemic toxicity. Given TAM accumulation is prevalent across all solid tumors, precisely universally applicable to treating various types cancers, potent effective

Язык: Английский

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Magnetic Persistent Luminescence Nanoparticles Repolarize Tumor-Associated Macrophages for Enhanced Cancer Immunotherapy

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 2094 - 2104

Опубликована: Май 3, 2025

Язык: Английский

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Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract Antigen‐presenting cells (APCs), particularly dendritic (DCs), play key roles in activating T for enhanced immune response cancer immunotherapy. In progression, an immunosuppressive tumor microenvironment (TME) is gradually developed, shielding from surveillance. One of the defects created by TME presence dysfunctional DCs, which triggers failures antigen recognition, processing, and presentation to cells, inducing impairment anti‐tumor responses. The demand ex vivo cell activation expansion replacement autologous DCs imperative adoptive therapy (ACT) due limited availability laborious isolation natural DCs. Therefore, fabrication artificial APCs (aAPCs) mimicking function holds promise immunotherapy, especially ACT. This review concentrates on design aAPCs using principles signaling immunological synapse: receptor (TCR)‐specific (signal 1), co‐stimulatory signal 2), cytokine‐mediated 3). Particularly, customization size, shape, stiffness, density, mobility ligands, as well dimension engagers optimization aAPCs, also discussed.

Язык: Английский

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Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 6059 - 6083

Опубликована: Май 1, 2025

Breast cancer remains the leading cause of female mortality worldwide, necessitating innovative and multifaceted approaches to address its various subtypes. Nanotechnology has attracted considerable attention due nanoscale dimensions, diverse carrier types, suitability for hydrophobic drug delivery, capacity controlled targeted administration. Nano-sized particles have become prevalent carriers therapeutic agents targeting breast cancer, thanks their reproducible synthesis adjustable properties, including size, shape, surface characteristics. In addition, certain nanoparticles can enhance effects synergistically. However, immune system often detects removes these nanoparticles, limiting efficacy. As a promising alternative, cell membrane-based delivery systems gained biocompatibility specificity. These membrane-coated are derived from sources, blood cells, stem cells. Leveraging unique properties membranes enables precise tumors associated biomarkers. Inspired by natural structures, disguise in bloodstream, enhancing retention time vivo improving tumor targeting. Consequently, membrane-derived (CMDNPs) been investigated potential applications diagnostics, photothermal therapy (PTT), vaccine development. This review comprehensively explores limitations clinical against cancer.

Язык: Английский

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Polyaniline-coated iron oxide nanoparticles reprogram macrophages and modulate the tumor microenvironment to inhibit breast cancer progression and metastasis

Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 21, 2025

Язык: Английский

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