ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(20), С. 23397 - 23415
Опубликована: Окт. 12, 2024
Hydrogen
sulfide
(H2S)
is
recognized
as
the
third
gaseous
signaling
molecule
present,
playing
a
crucial
role
in
cellular
processes.
When
designing
nanomaterials,
H2S
not
only
serves
cancer
biomarker
but
also
directly
influences
tumor
cell
proliferation
and
metastasis
by
modulating
its
concentration.
However,
gas
donor
inability
to
actively
accumulate
within
tumors
release
controlled
manner
results
restricted
treatment
efficacy
potential
toxic
side
effects.
Near-infrared
(NIR)
responsive
photothermal
probes
are
characterized
their
rapid
response
time,
high
selectivity,
sensitivity,
noninvasive
attributes.
They
offer
opportunity
for
precise,
real-time,
modulation
of
concentrations
at
both
murine
levels.
The
integration
therapy
with
other
modalities
through
multifunctional
nanocarrier
platforms
shows
promise
enhancing
outcomes
while
minimizing
adverse
development
capable
controllably
properties
considered
essential
yet
challenging
academic
research.
This
Review
critically
assesses
two
primary
approaches
NIR
strategies
involving
H2S:
targeted
utilizing
combining
alternative
modalities.
Additionally,
this
addresses
current
limitations
these
technologies
outlines
future
directions
advancement.
Overall,
aims
provide
insights
guidance
seamless
therapy,
aligning
rigorous
standards
journals.
Abstract
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
and
controllable
local
cancer
treatment
for
cholangiocarcinoma
(CCA).
However,
the
efficacy
of
PDT
hindered
by
intratumoral
hypoxia
presence
an
antioxidant
microenvironment.
To
address
these
limitations,
combining
with
gas
may
be
promising
strategy
to
enhance
tumor
oxygenation.
Moreover,
augmentation
oxidative
damage
induced
can
achieved
inhibiting
NRF2,
core
regulatory
molecule
involved
in
response.
In
this
study,
integrated
nanotherapeutic
platform
called
CMArg@Lip,
incorporating
therapies
using
ROS‐responsive
liposomes
encapsulating
photosensitizer
Ce6,
NO
gas‐generating
agent
L‐arginine,
NRF2
inhibitor
ML385,
successfully
developed.
The
utilization
CMArg@Lip
effectively
deals
challenges
posed
microenvironment,
resulting
elevated
levels
subsequent
induction
ferroptosis
CCA.
Additionally,
findings
suggest
that
exhibits
notable
immunomodulatory
effects,
including
promotion
immunogenic
cell
death
facilitation
dendritic
maturation.
Furthermore,
it
contributes
anti‐tumor
function
cytotoxic
T
lymphocytes
through
downregulation
PD‐L1
expression
cells
activation
STING
signaling
pathway
myeloid‐derived
suppressor
cells,
thereby
reprogramming
immunosuppressive
microenvironment
via
various
mechanisms.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Hydrogen
therapy
has
shown
new
potential
in
cancer
treatment,
particularly
high-pressure
and
hypoxic
areas,
where
it
demonstrates
the
ability
to
alter
tumor
microenvironment
regulate
metabolism.
disrupts
mitochondrial
function
of
cells,
interferes
with
their
energy
metabolism,
ultimately
leads
depletion
apoptosis.
In
this
study,
a
sonocatalyst
(BPM),
is
designed
generate
hydrogen
oxygen
situ
within
tumors,
further
enhancing
therapeutic
efficacy.
The
mesocrystalline
structure
BPM,
composed
bismuth
fluoride,
polyoxometalates,
molybdenum
carbide,
significantly
improves
charge
separation
electron
transfer
efficiency
under
ultrasound
irradiation,
resulting
an
efficient
water-splitting
reaction.
By
simultaneously
generating
depleting
glutathione,
BPM
effectively
triggers
oxidative
stress
alleviates
hypoxia,
thereby
disrupting
inhibiting
metabolism
cells.
Additionally,
enhances
antitumor
immune
responses
by
promoting
dendritic
cell
maturation,
activating
T
lymphocytes,
polarizing
macrophages
toward
M1
phenotype,
reversing
immunosuppressive
state
microenvironment.
results
indicate
that
holds
for
gas-immunotherapy
combination
treatments,
offering
multifunctional
strategy
improve
outcomes.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
515, С. 215921 - 215921
Опубликована: Май 21, 2024
Nitric
oxide
(NO)
is
an
important
biochemical
molecule
that
endogenously
produced
to
act
for
instance
as
neurotransmitter,
effect
cell
growth,
or
regulate
the
immune
response.
Therapeutic
treatment
with
exogeneous
NO
difficult
owing
its
gaseous
and
reactive
nature
and,
not
surprising,
specific
molecules
deliver
have
been
developed.
Amongst
various
triggers
deliberately
release
from
these
NO-releasing
molecules,
light
most
elegant
allows
a
high
degree
of
control
over
time
location
NO-release.
For
therapeutic
applications,
it
necessary
use
long-wavelength
light,
preferably
in
red
near
infrared
region,
which
challenging
achieve.
This
review
gives
overview
on
approaches
red-shift
activation
wavelength
light-activated
NO-release
nitrosoamines,
o-substituted
nitroarenes,
L-arginine,
cupferron,
nitrosyl
metal
complexes.
While
focusing
single
photon
excitation
events,
direct
mechanisms
are
covered
well
photoelectron
transfer,
energy
chemiluminescence
photothermal
light-triggered
oxidation
pathways.
each
NO-releaser
class,
photochemical
mechanism
discussed,
biological
applications
mentioned.
Translational Oncology,
Год журнала:
2024,
Номер
45, С. 101975 - 101975
Опубликована: Апрель 30, 2024
Hepatocellular
carcinoma
(HCC)
is
the
most
prevalent
type
of
liver
cancer,
mainly
occurring
in
Asian
countries
with
an
increased
incidence
rate
globally.
Currently,
several
kinds
therapies
have
been
deployed
for
HCC
therapy
including
surgical
resection,
chemotherapy,
radiotherapy
and
immunotherapy.
However,
this
tumor
still
incurable,
requiring
novel
strategies
its
treatment.
The
nanomedicine
has
provided
new
insights
regarding
treatment
cancer
that
liposomes
as
lipid-based
nanoparticles,
widely
applied
due
to
their
biocompaitiblity,
high
drug
loading
ease
synthesis
modification.
current
review
evaluates
application
therapy.
drugs
genes
lack
targeting
ability
into
tissues
cells.
Therefore,
or
on
can
increase
accumulation
site
suppression.
Moreover,
stimuli-responsive
pH-,
redox-
light-sensitive
are
able
deliver
microenvironment
improve
therapeutic
index.
Since
a
number
receptors
upregulate
cells,
functionalization
lactoferrin
peptides
promote
towards
phototherapy
be
induced
by
through
phtoosensitizers
stimulate
photothermal-
photodynamic-driven
ablation
Overall,
findings
line
fact
promising
nanocarriers
HCC.
