Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study

ACS Omega, Год журнала: 2025, Номер 10(1), С. 1207 - 1225

Опубликована: Янв. 3, 2025

Manufacturing bioactive materials for drug delivery involves developing that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is optimize therapeutic efficacy reduce side effects by combining knowledge from engineering, biology, pharmacology. This study presents detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," "drug delivery" identify highlight significant advancements field. From Web of Science, 36,504 articles were analyzed, 171 selected deeper identifying key journals, countries, institutions, authors. results field's interdisciplinary nature, grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, glass, tissue engineering. Future research this area will focus on more effective precise systems using technologies like 3D printing nanotechnology enhance customization control release, aiming efficient therapies.

Язык: Английский

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Advances and challenges in biomaterials for tendon and enthesis repair

Bioactive Materials, Год журнала: 2025, Номер 47, С. 531 - 545

Опубликована: Фев. 20, 2025

Язык: Английский

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Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives

Materials & Design, Год журнала: 2024, Номер 243, С. 113072 - 113072

Опубликована: Июнь 6, 2024

Musculoskeletal disorders, as one of the prevalent categories ailments, exert significant impacts on individuals' lives, occupations, and physical activities. Degenerative changes, injuries, infections, tumor resections causing defects in musculoskeletal tissues such cartilage, bones, skeletal muscles, menisci, ligaments, rotator cuffs can detrimentally affect patients' quality life mental well-being. Traditional autologous allogeneic transplantations have been clinically employed. However, transplantation suffers from limitation a finite number transplantable tissues, while faces challenges immune rejection. The extracellular matrix (ECM) serves natural scaffold for cells to fulfill physiological functions adhesion, proliferation, differentiation. Decellularized (dECM) emerges promising biomaterial generated through specific tissue or organ decellularization. Leveraging 3D bioprinting technology, dECM-based biomaterials enable customized printing construction. This study reviews various decellularization techniques, post-decellularization strategies, commonly used technologies. It summarizes integration with technology applied system research. These investigations showcase exciting potential system, offering prospects clinical translation orthopedics.

Язык: Английский

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Injectable melatonin carbon dot composite hydrogel enhances anti-inflammatory and tenogenic differentiation of tendon-derived stem cells for minimally invasive treatment of Achilles tendinopathy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160720 - 160720

Опубликована: Фев. 1, 2025

Язык: Английский

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CBD-Conjugated BMP-Inhibiting Exosomes on Collagen Scaffold Dual-Target Achilles Tendon Repair: Synergistic Regeneration and Heterotopic Ossification Prevention

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101790 - 101790

Опубликована: Апрель 22, 2025

Язык: Английский

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Metal-Phenolic Network Coatings Delivering Stem Cells from Apical Papilla Derived Nanovesicles for Bone Defect Regeneration

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

SCAPs-NV were reversibly loaded into tannic acid–Fe 3 -modified decellularized diaphragm tendons. The composite scaffolds showed dual functions: promoting osteogenic differentiation and angiogenesis.

Язык: Английский

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Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 600 - 612

Опубликована: Май 6, 2025

Язык: Английский

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Collagen targeting BMSCs-derived extracellular vesicles coupled with decellularized tendon scaffold for anterior cruciate ligament reconstruction

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163540 - 163540

Опубликована: Май 1, 2025

Язык: Английский

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Protein hydrogels for biomedical applications

Biosurface and Biotribology, Год журнала: 2024, Номер 10(3), С. 106 - 131

Опубликована: Сен. 1, 2024

Abstract Hydrogels, characterised as highly hydrophilic three‐dimensional polymer networks, have gained increasing attention due to their unique physicochemical properties, finding applications in various fields. Natural hydrogels exhibit higher biocompatibility and biodegradability compared traditional synthetic hydrogels. Proteins, being the principal materials of natural hydrogels, bear numerous modifiable functional groups. The resultant hydrogel possesses responsiveness, adjustable degradability, underway an excellent biomaterial. Seven common raw used construct protein are introduced. In terms comparing with authors conduct a detailed analysis comparison, highlighting advantages biodegradability, summarising characteristics. also address limitations list existing strengthening cross‐linking strategies, proposing new insights overcome application limits Additionally, drug delivery, biosensing, bio‐inks tissue engineering discussed. conclude by current challenges faced prospecting its future development.

Язык: Английский

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The role of extracellular vesicles in the treatment of tendinopathy by regulating the pathological immune microenvironment

Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 156489 - 156489

Опубликована: Окт. 9, 2024

Язык: Английский

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