International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8929 - 8947
Опубликована: Сен. 1, 2024
Introduction:
Cell
death
regulation
holds
a
unique
value
in
the
field
of
cancer
therapy.
Recently,
disulfidptosis
has
garnered
substantial
scientific
attention.
Previous
studies
have
reported
that
sonodynamic
therapy
(SDT)
based
on
reactive
oxygen
species
(ROS)
can
regulate
cell
death,
achieving
an
limited
anti-cancer
effect.
However,
integration
SDT
with
as
strategy
not
been
extensively
developed.
In
this
study,
we
constructed
artificial
membrane
sonosensitizer,
specifically,
nanoliposome
(SC@lip)
coated
combination
chemotherapy
medicine
Sorafenib
(Sora)
and
sonosensitizer
Chlorin
e6
(Ce6),
to
realize
one-stop
enhanced
effect
induces
disulfidptosis-like
death.
Methods:
Ce6
were
co-encapsulated
into
PEG-modified
liposomes,
SC@Lip
was
using
simple
rotary
evaporation
phacoemulsification
method.
The
phagocytosis,
ROS
generation
ability,
glutathione
(GSH)
depletion
lipid
peroxidation
(LPO),
mediated
by
under
ultrasound
(US)
irradiation
evaluated.
Based
4T1
subcutaneous
tumor
model,
both
vivo
biological
safety
assessment
efficacy
assessed.
Results:
exhibits
high
efficiency
cellular
phagocytosis.
After
being
endocytosed
cells,
abundant
produced
activation,
survival
rates
below
5%.
When
applied
inhibited
growth
prolonged
time
mice.
vitro
experiments
show
enhance
trigger
thus
anti-tumor
vivo.
Conclusion:
is
multifunctional
nanoplatform
membrane,
which
integrate
functions
sonosensitization
GSH
biocompatible
nanoplatform,
be
used
promote
Keywords:
disulfidptosis,
therapy,
species,
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
35(7), С. 1015 - 1023
Опубликована: Июнь 21, 2024
Currently,
clinical
therapeutic
strategies
for
nasopharyngeal
carcinoma
(NPC)
confront
insurmountable
dilemmas
in
which
surgical
resection
is
incomplete
and
chemotherapy/radiotherapy
has
significant
side
effects.
Phototherapy
offers
a
maneuverable,
effective,
noninvasive
pattern
NPC
therapy.
Herein,
we
developed
lysosome-targeted
pH-responsive
nanophototheranostic
near-infrared
II
(NIR-II)
fluorescence
imaging-guided
photodynamic
therapy
(PDT)
photothermal
(PTT)
of
NPC.
A
S-D-A-D-S-type
NIR-II
phototheranostic
molecule
(IRFEM)
encapsulated
within
the
acid-sensitive
amphiphilic
DSPE-Hyd-PEG2k
to
form
IRFEM@DHP
nanoparticles
(NPs).
The
prepared
exhibits
good
accumulation
acidic
lysosomes
facilitating
release
IRFEM,
could
disrupt
lysosomal
function
by
generating
an
amount
heat
ROS
under
laser
irradiation.
Moreover,
guidelines
enhance
accuracy
PTT/PDT
avoid
damage
normal
tissues.
Remarkably,
enable
efficient
antitumor
effects
both
Nanoscale Advances,
Год журнала:
2024,
Номер
6(17), С. 4275 - 4308
Опубликована: Янв. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Inappropriate
glucose
metabolism
in
cancer
cells
is
associated
with
immunosuppressive
tumor
microenvironments
(TMEs).
Although
glycolysis
inhibition
enhances
T
cell-mediated
immune
responses,
the
integrated
platforms
combining
immunotherapy
remain
underdeveloped.
To
address
this
gap,
a
metabolism-targeted
poly(amino
acid)
nanoformulation
of
oxaliplatin(IV)-aspirin
prodrug
(NP/OXA-ASP2)
developed
to
improve
chemo-immunotherapy
by
suppressing
glycolysis.
This
nanoparticle
exhibits
selective
release,
discharging
90.0%
OXA-ASP2
under
reductive
conditions
within
36
h.
Furthermore,
over
80%
converts
OXA
and
ASP
12
h,
promoting
mitochondrial
damage
inhibition,
which
amplifies
immunogenic
cell
death
induced
OXA.
In
addition,
glycolytic
flux
reduces
lactate
leakage,
mitigating
TMEs.
Together,
these
mechanisms
contribute
stronger
efficacy.
Compared
plus
formulation,
NP/OXA-ASP2
demonstrates
superior
performances,
reducing
levels
at
site
25.4%,
increasing
proportion
cytotoxic
lymphocytes
1.53
times,
decreasing
regulatory
2.20
improving
1.39-fold
rate.
These
findings
underscore
that
promising
platform
for
integrating
metabolic
regulation
immunomodulation
holds
significant
potential
advancing
clinical
chemo-immunotherapy.
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
low
drug
delivery
rate
of
systemic
chemotherapyto
metastatic
lymph
nodes
(LNs)
may
be
due
to
tumor
growth
without
tumorneovascularization
in
the
LNs,
loss
existing
blood
vessels
and
sinusesdue
growth,
increased
intranodal
pressure.
lymphatic
drugdelivery
system
(LDDS)
is
a
method
injecting
anticancer
drugs
directly
intothe
LNs
can
overcome
these
problems.
world's
first
specific
clinicalstudy
using
LDDS
for
head
neck
cancer
started
2024
Japan.
In
thisreview,
background
development
up
present
clinicaltrials
described.
MXH10/Mo-lpr/lpr(MXH10/Mo/lpr)
recombinant
inbred
model
mouse,
vascular
flowthrough
clinical
N0
(cN0)
LN
model,
preclinical
studies
LDDS,and
its
application
treat
cancer.
Conventionally,
hematogenous
administrationhave
been
focus
attention
LNs.
methodfor
so
it
important
develop
solventand
that
increase
uniformity
distributionwithin
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
Embolotherapy
is
an
effective
antitumor
method,
which
essentially
blocks
the
oxygen
supply
and
induces
hypoxia
to
treat
tumors;
however,
traditional
practices
demand
high
expertise
harbor
risks
of
complications.
This
study
presents
a
mesoporous
polydopamine-based
(MPDA)
drug
delivery
platform
modified
by
engineered
fusion
proteins,
can
specifically
embolize
tumor
blood
vessels
deliver
hypoxia-activated
prodrug
tirapazamine
(TPZ).
The
protein
consists
affibody
targeting
HER-2,
substrate
for
MMP-2,
RGD
tripeptide,
truncated
tissue
factor
(tTF),
then
connected
MPDA
loaded
with
TPZ.
nanodrug
actively
target
interact
MMP-2
in
microenvironment
(TME),
vessels;
then,
under
TME
acidic
circumstances,
releases
TPZ,
activated
aggravated
embolization,
kills
tumors.
embolization
strategy,
only
specific
conditions,
extremely
safe,
it
compensates
inadequacies
conventional
therapy,
while
also
addressing
issue
deficiency
therapy.
C–C
Motif
Chemokine
Ligand
5
(CCL5)
is
known
for
its
role
in
immune
regulation
and
has
been
implicated
cancer
progression.
However,
expression
prognostic
significance
pan-cancer
require
comprehensive
evaluation.
This
study
was
initiated
to
decipher
the
of
CCL5
genes.
In
silico
analyses
involving
various
online
databases
molecular
experiments
knockdown
KIRC
cell
lines
evaluated
proliferation,
colony
formation,
migration.
significantly
up-regulated
several
cancers.
High
correlated
with
poorer
overall
survival
kidney
renal
carcinoma
(KIRC)
esophageal
(ESCA)
patients.
Promoter
hypomethylation
elevated
prognosis.
mutations
were
rare;
indicating
driven
by
overexpression
rather
than
genetic
alterations.
Positive
correlations
inhibitory
MHC
genes
suggested
CCL5's
fostering
an
immunosuppressive
tumor
microenvironment.
increased
infiltration,
particularly
CD8
T
cells
macrophages.
did
not
influence
drug
sensitivity.
resulted
reduced
migration,
underscoring
critical
dynamics.
Our
highlights
progression
prognosis,
ESCA.
modulating
microenvironment
potential
as
a
therapeutic
target
warrant
further
investigation.
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Apigenin,
a
widely
distributed
bioactive
flavonoid,
has
recently
gained
excellent
attention
among
researchers
as
an
effective
anticancer
drug
that
can
alternate
cancer
signaling
pathways,
induce
programmed
cell
death,
and
reduce
tumor
growth
in
various
types.
Despite
its
impressive
anti-neoplastic
activity,
high
hydrophobicity
nonspecific
biodistribution
make
apigenin
difficult
for
pharmaceutical
application.
We
highlighted
the
therapeutic
potential
of
derivatives
different
types,
along
with
their
mechanism
action.
Nanoengineered
delivery
systems
have
remarkable
applications
minimizing
degradation
enhancing
efficacy
drugs
sustained
release,
prolonged
blood
retention
time,
reduced
off-target
toxicities.
This
review
evaluated
explored
molecular
interactions
this
novel
flavonoid
pathways
to
selectively
inhibit
neoplastic
development
multiple
To
ensure
complete
coverage
research
area,
google
scholar,
PubMed,
web
science
were
used
find
not
only
most
relevant,
but
also
connected
similar
articles.
A
comprehensive
overview
nanotherapy
treatment
establish
platform
overcome
difficulties
application
efficient
clinical
translation
from
bench
bedside.
