Extracellular Vesicle, Год журнала: 2024, Номер 4, С. 100059 - 100059
Опубликована: Дек. 1, 2024
Язык: Английский
Biomedical Materials, Год журнала: 2024, Номер 19(3), С. 032004 - 032004
Опубликована: Апрель 9, 2024
Abstract Electrospinning technique converts polymeric solutions into nanoscale fibers using an electric field and can be used for various biomedical clinical applications. Extracellular vesicles (EVs) are cell-derived small lipid enriched with biological cargo (proteins nucleic acids) potential therapeutic In this review, we discuss extending the scope of electrospinning by incorporating stem EVs, particularly exosomes, nanofibers their effective delivery to target tissues. The parameters during biopolymers limit stability functional properties cellular products. However, careful consideration process requirements, these significantly improve stability, leading longevity, effectiveness, sustained localized release. Electrospun known encapsulate or surface-adsorb payloads such as proteins, enzymes, acids. Small specifically have recently attracted attention researchers working on regeneration tissue engineering because broad distribution enormous agents. This review focuses current developments in delivering molecules, a special emphasis exosomes. It also suggests prospective approaches that adapted safely combine two systems exponentially enhance benefits engineering, medical device coating, drug
Язык: Английский
Процитировано
2
Biomedical Physics & Engineering Express, Год журнала: 2024, Номер 10(4), С. 045001 - 045001
Опубликована: Апрель 19, 2024
Extracellular vesicles (EVs) have been recognized as one of the promising specific drugs for myocardial infarction (MI) prognosis. Nevertheless, low intramyocardial retention EVs remains a major impediment to their clinical application. In this study, we developed silk fibroin/hydroxypropyl cellulose (SF/HPC) composite hydrogel combined with AC16 cell-derived targeted modification by folic acid treatment acute repair. were functionalized distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG-FA) via noncovalent interaction targeting and accelerating
Язык: Английский
Процитировано
2
European Polymer Journal, Год журнала: 2024, Номер unknown, С. 113457 - 113457
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 54 - 80
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
1
Cancer Drug Resistance, Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements chemotherapeutic agents targeted therapies, cancers develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications delivery because of natural origin, biocompatibility, ability cross biological barriers. Using the unique properties EVs could enhance accumulation at target sites, minimize systemic toxicity, precisely specific cells. Here, we discuss characteristics functionalization EVs, mechanisms engineered overcome resistance. This review provides comprehensive overview EV-based systems overcoming We highlight revolutionize offer promising strategies more effective modalities.
Язык: Английский
Процитировано
1
BioMedInformatics, Год журнала: 2024, Номер 4(2), С. 1531 - 1555
Опубликована: Июнь 9, 2024
In vaccine development, many use the spike protein (S protein), which has multiple “spike-like” structures protruding from spherical structure of coronavirus, as an antigen. However, there are concerns about its effectiveness and toxicity. When S is used in a vaccine, ability to attack viruses may be weak, eliciting immunity will only last for short period time. Moreover, it cause “antibody-dependent immune enhancement”, can enhance infections. addition, three-dimensional (3D) epitopes essential functional analysis structure-based design. Additionally, during viral infection, large amounts extracellular vesicles (EVs) secreted infected cells, function communication network between cells coordinate response infection. Under conditions where SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) molecular vaccination produces overwhelming glycoprotein, significant proportion overproduced intracellular glycoprotein transported via EVs. Therefore, important understand infection mechanisms SARA-CoV-2 EV-dependent EV-independent uptake into model processes based on 3D structural features at interaction sites.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Процитировано
0
Biomacromolecules, Год журнала: 2024, Номер unknown
Опубликована: Сен. 12, 2024
Critical limb ischemia (CLI) is a peripheral arterial disease resulting from chronic inflammation of vascular systems. Recent studies have shown that inhibiting macrophage has the potential to treat CLI, and extracellular vesicles (EVs) endothelial cells can inhibit activation. However, limited cell-targeting capabilities rapid clearance EVs injection site limit in vivo application EVs. Here, we modified with platelet membranes (pM/EVs) boost inhibition effects on developed an injectable alginate-based collagen composite (ACC) hydrogel for localized delivery pM/EVs (pM/EVs@ACC) CLI treatment. We found effectively vitro. Furthermore, pM/EVs@ACC treatment significantly promotes recovery functions, restoring feet' blood supply relieving inflammation. Our findings provide compelling evidence system mediating promising strategy
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106189 - 106189
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0
Clinica Chimica Acta, Год журнала: 2024, Номер 565, С. 120011 - 120011
Опубликована: Окт. 20, 2024
Язык: Английский
Процитировано
0