RSC Mechanochemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 18, 2024
Carbamoylketoximes of N -pentenyl-substituted secondary amines give access to cyclic tertiary amine bases by a subsequent 5- exo-trig cyclization after homolytic bond scission the mechanophore induced through polymer mechanochemistry.
Язык: Английский
Macromolecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Contemporary polymer network materials, such as hydrogels and elastomers, require not only enhanced mechanical properties but also adaptability during or after use. Polymer mechanochemistry, which utilizes force to induce chemical reactions within polymers, has shown great potential in meeting these demands. This Perspective will explore how mechanophores, when integrated into networks, can regulate microscale fracture pathways, either strengthening weakening the materials. Additionally, it examine force-induced bond scission trigger additional adaptively adjust structures for on-demand functions. These force-activated could lead strategies strengthening, reshaping, patterning materials through growth, or, conversely, result extensive material degradation. The highlight of tough double mechanochemical that use energy drive an efficient controllable manner. opens up new possibilities developing force-triggered "living materials" similar biological systems.
Язык: Английский
Процитировано
1
ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability penetrate deep tissue with spatial temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical chemical effects ultrasonication for controlled activation prodrugs. In polymer mechanochemistry, materials scientists exploit sonomechanical effect acoustic cavitation mechanochemically activate force-sensitive On other hand, researchers sonodynamic therapy adopt fundamentally distinct methodologies, utilizing sonochemical (e.g., generation reactive oxygen species) ultrasound presence sonosensitizers induce transformations that This cross-disciplinary review comprehensively examines these two divergent yet interrelated approaches, both which originated from cavitation. It highlights molecular design strategies potential diverse therapeutic contexts, chemotherapy immunotherapy gene methods, discusses future directions this rapidly advancing domain.
Язык: Английский
Процитировано
7
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 17, 2025
Cancer continues to be one of the leading causes death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, surgery have limitations. RNA therapy vaccines hold considerable promise an alternative for their ability enable personalized with improved efficacy reduced side effects. The principal approach is induce a specific immune response against cells. However, major challenge in immunotherapy predict which patients will respond treatment monitor vaccine during treatment. Theragnostics, integration diagnostic therapeutic capabilities into single hybrid platform system, has potential address these challenges by enabling real-time monitoring while allowing endogenously controlled adjustments. In this article, we review current state-of-the-art theragnostics including imaging agents, biomarkers, other tools relevant cancer, application development personalization. We also discuss opportunities further clinical translation vaccines.
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(2)
Опубликована: Фев. 1, 2025
ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.
Язык: Английский
Процитировано
0
ACS Applied Optical Materials, Год журнала: 2024, Номер 2(9), С. 1764 - 1769
Опубликована: Март 5, 2024
Optical force probes (OFPs) are mechanochemically latent sensors that visualize stress and strain at the molecular level by changing their optical properties upon force-induced bond scission. Yet, incorporation of mechanochemical responsivity into established fluorophore motifs is difficult, which why red- near-infrared (NIR)-excited OFPs rarely reported. Here, an approach to solve this issue presented, relying on triplet–triplet annihilation photon upconversion (TTA UC). based Diels–Alder adducts anthracene maleimide used as annihilators, a phthalocyanine derivative triplet sensitizer. By annihilator motif in center linear polymer chains subsequent ultrasonication, activated. In combination with sensitizer red excitation, TTA UC leads yellow emission only after scission but not its pristine form. Thereby, activated demonstrated excitation energies low NIR light.
Язык: Английский
Процитировано
3
Polymer, Год журнала: 2024, Номер 298, С. 126920 - 126920
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
3
Опубликована: Июнь 19, 2024
Today, polymeric Drug Delivery Systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with taurinate (PKT) or sulfanilate (PKSK) employed biocompatible carriers for Vancomycin infections. Mod-ified PKs were easily prepared by Paal-Knorr reaction loaded at variable pH. All polymers characterized FT-IR, DSC, TGA, SEM elemental analysis. Antimicrobial activity was tested Gram positive Staphylococcus aureus ATCC 25923 correlated to the different pH used its loading (between 2.3 8.8). Distinctively, minimum inhibitory con-centrations achieved PKT PKSK are similar, 0.23μg/mL 0.24μg/mL respectively, i.e. six times lower that alone. The use of aliphatic has thus demonstrated be a promising way obtain very efficient DDS.
Язык: Английский
Процитировано
2
Smart Materials in Medicine, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
Chemistry - A European Journal, Год журнала: 2024, Номер 30(57)
Опубликована: Авг. 5, 2024
Covalent polymer chains are known to undergo mechanochemical events when subjected mechanical forces. Such force-coupled reactions, like C-C bond scission in homopolymers, typically occur a non-selective manner but with higher probability at the mid-chain. In contrast, block copolymers (BCPs), composed of two or more chemically distinct linked by covalent bonds, have recently been shown exhibit significantly different reactivities and selectivities. These differences may be attributable atypical conformations adopted their chains, compared regular random coil. Beyond individual molecules, BCPs self-assemble into ordered aggregates solution, non-covalent interactions between lead meaningful acceleration activation embedded force-sensitive motifs. Furthermore, microphase segregation bulk creates periodically dispersed polydomains, locking blocks specific which also affect reactivity, morphologies influencing reactivity varying extents. This review summarizes studies mechanochemistry over past decades, from molecular level assemblies, up materials.
Язык: Английский
Процитировано
1
Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101375 - 101375
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1