Computational analysis of controlled drug release from porous polymeric carrier with the aid of Mass transfer and Artificial Intelligence modeling

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 18, 2024

Язык: Английский

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Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Polymers, Год журнала: 2024, Номер 16(13), С. 1890 - 1890

Опубликована: Июль 2, 2024

Today, polymeric drug delivery systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with sodium taurinate (PKT) or potassium sulfanilate (PKSK) employed carriers for Vancomycin infections. Modified PKs were easily prepared by the Paal–Knorr reaction loaded at a variable pH. All polymers characterized FT-IR, DSC, TGA, SEM, elemental analysis. Antimicrobial activity was tested Gram-positive Staphylococcus aureus ATCC 25923 correlated to different pHs used its loading (between 2.3 8.8). particular, minimum inhibitory concentrations achieved PKT PKSK similar, 0.23 μg/mL 0.24 μg/mL, respectively, i.e., six times lower than that alone. The use of aliphatic has thus demonstrated be promising way obtain very efficient DDS.

Язык: Английский

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Mechanochemical Release of 9,10-Diphenylanthracene via Flex-Activation of Its 1,4-Diels–Alder Adduct

ACS Macro Letters, Год журнала: 2024, Номер unknown, С. 14 - 19

Опубликована: Дек. 16, 2024

Flex-activated mechanophores capable of releasing small molecules utilize bond bending to facilitate their mechanochemical activation without compromising the overall macromolecular architecture, which have great potential in various applications. However, development such remains underexplored. Here we report a novel flex-activated mechanophore based on 1,4-Diels-Alder (DA) adduct 9,10-diphenylanthracene (DPA) with acetylenedicarboxylate (ADC). Compression mechanophore-crosslinked polymer networks mechanochemically activates weakly fluorescent DPA-ADC undergo retro-DA reaction accompany release highly DPA (quantum yield close unity), as confirmed by fluorescence spectroscopy and gas chromatography-mass spectrometry (GC-MS) analysis. As new member family mechanophores, this fluorogenic possesses promising applications stress sensing damage detection.

Язык: Английский

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Mechanochemical generation of nitrogen-centred radicals for the formation of tertiary amines in polymers

RSC Mechanochemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

Carbamoylketoximes of N -pentenyl-substituted secondary amines give access to cyclic tertiary amine bases by a subsequent 5- exo-trig cyclization after homolytic bond scission the mechanophore induced through polymer mechanochemistry.

Язык: Английский

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