International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 705 - 721
Опубликована: Янв. 1, 2025
The
metabolic
activity
of
tumor
cells
leads
to
the
acidification
surrounding
microenvironment,
which
provides
new
strategies
for
application
nanotechnology
in
cancer
therapy.Researchers
have
developed
various
types
pH-responsive
nanomaterials
based
on
acidic
microenvironment.This
review
an
in-depth
discussion
design
mechanisms,
drug-loading
strategies,
and
pathways
microenvironment-responsive
nanodrug
delivery
systems.These
materials
trigger
drug
release
upon
reaching
enhancing
therapeutic
targeting
reducing
toxicity
healthy
cells.pH-responsive
include
organic
nanomaterials,
inorganic
composite
nanomaterials.Additionally,
this
outlines
prospects,
challenges
aiming
promote
development
clinical
translation
field.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 116951 - 116951
Опубликована: Июнь 19, 2024
The
emerging
strategy
of
biomimetic
nanoparticles
(NPs)
via
cellular
membrane
camouflage
holds
great
promise
in
cancer
therapy.
This
scholarly
review
explores
the
utilization
membranes
derived
from
diverse
entities;
blood
cells,
immune
stem
and
bacterial
cells
as
examples
NP
coatings.
camouflaging
endows
NPs
with
nuanced
tumor-targeting
abilities
such
self-recognition,
homotypic
targeting,
long-lasting
circulation,
thus
also
improving
tumor
therapy
efficacy
overall.
comprehensive
examination
encompasses
a
variety
cell
camouflaged
(CMCNPs),
elucidating
their
underlying
targeted
mechanisms
delineating
strategies
for
anti-cancer
applications.
Furthermore,
systematically
presents
synthesis
source
materials
methodologies
employed
order
to
construct
characterize
these
CMCNPs,
specific
emphasis
on
use
treatment.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 8, 2024
Abstract
Mitochondria
occupy
a
central
role
in
the
biology
of
most
eukaryotic
cells,
functioning
as
hub
oxidative
metabolism
where
sugars,
fats,
and
amino
acids
are
ultimately
oxidized
to
release
energy.
This
crucial
function
fuels
variety
cellular
activities.
Disruption
mitochondrial
is
common
feature
many
diseases,
including
cancer,
neurodegenerative
conditions
cardiovascular
diseases.
Targeting
tumor
cell
with
multifunctional
nanosystems
emerges
promising
strategy
for
enhancing
therapeutic
efficacy
against
cancer.
review
comprehensively
outlines
pathways
metabolism,
emphasizing
their
critical
roles
energy
production
metabolic
regulation.
The
associations
between
aberrant
initiation
progression
cancer
highlighted,
illustrating
how
these
disruptions
contribute
oncogenesis
sustainability.
More
importantly,
innovative
strategies
employing
nanomedicines
precisely
target
therapy
fully
explored.
Furthermore,
key
challenges
future
directions
this
field
identified
discussed.
Collectively,
provides
comprehensive
understanding
current
state
potential
nanomedicine
targeting
offering
insights
developing
more
effective
therapies.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10712 - 10712
Опубликована: Окт. 5, 2024
Within
the
field
of
nanomedicine,
which
is
revolutionizing
cancer
treatment,
solid
lipid
nanoparticles
(SLNs)
have
shown
advantages
over
conventional
chemotherapy
when
tested
on
cells
in
preclinical
studies.
SLNs
proven
to
be
an
innovative
strategy
for
treatment
triple-negative
breast
cells,
providing
greater
efficiency
than
existing
treatments
various
The
encapsulation
antineoplastic
drugs
has
facilitated
a
sustained,
controlled,
and
targeted
release,
enhances
therapeutic
reduces
adverse
effects.
Moreover,
surface
can
modified
increase
efficiency.
For
instance,
coating
these
particles
with
polyethylene
glycol
(PEG)
decreases
their
opsonization,
resulting
longer
life
circulatory
system.
creation
positively
charged
cationic
(cSLNs),
achieved
by
utilization
surfactants
or
ionic
lipids
structural
groups,
increases
affinity
cell
membranes
plasma
proteins.
Hyaluronic
acid
been
added
so
that
distinct
pH
tumor
would
stimulate
release
drug
and/or
genetic
material.
current
review
summarizes
recent
research
SLNs,
focusing
transport
agents
cytotoxic
effect
cancer.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 27, 2025
Direct
reprogramming
has
garnered
considerable
attention
due
to
its
capacity
directly
convert
differentiated
cells
into
desired
cells.
Fibroblasts
are
frequently
employed
in
studies
their
abundance
and
accessibility.
However,
they
also
the
key
drivers
progression
of
fibrosis,
a
pathological
condition
characterized
by
excessive
extracellular
matrix
deposition
tissue
scarring.
Furthermore,
initial
stage
typically
involves
deactivating
fibrotic
pathways.
Hence,
direct
offers
valuable
method
regenerate
target
for
repair
while
simultaneously
reducing
tendencies.
Understanding
link
between
fibrosis
could
help
develop
effective
strategies
treat
damaged
with
potential
risk
fibrosis.
This
review
summarizes
advances
reveals
anti-fibrosis
effects
various
organs
such
as
heart,
liver,
skin.
we
dissect
mechanisms
influenced
molecules
including
TGF-β
signaling,
mechanical
inflammation
epigenetic
modifiers,
metabolic
regulators.
Innovative
methods
fibroblast
like
small
molecules,
CRISPRa,
modified
mRNA,
challenges
cellular
heterogeneity
senescence
faced
vivo
reprogramming,
discussed.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 4201 - 4234
Опубликована: Апрель 1, 2025
Although
immunotherapy
has
made
significant
progress
in
cancer
treatment,
its
limited
responsiveness
greatly
hindered
widespread
clinical
application.
The
Warburg
effect
tumor
cells
creates
a
microenvironment
(TME)
characterized
by
hypoxia,
low
glucose
levels,
and
high
lactate
which
severely
inhibits
the
antitumor
immune
response.
Consequently,
targeting
metabolism
to
reprogram
TME
is
considered
an
effective
strategy
for
reversing
immunosuppression
evasion.
Numerous
studies
have
been
conducted
on
enhancing
efficacy
through
delivery
of
modulators
via
nanocarriers.
This
review
provides
comprehensive
overview
metabolic
characteristics
tumors
their
impacts
system,
as
well
nanodelivery
strategies
enhance
immunotherapy.
These
include
inhibiting
key
glycolytic
enzymes,
blocking
transporters,
utilizing
oxidase
oxidase.
Furthermore,
this
article
reviews
recent
advancements
synergistic
therapy
involving
metabolism-targeted
combined
with
other
treatments,
such
chemotherapy,
radiotherapy
(RT),
phototherapy,
Finally,
we
discuss
limitations
future
prospects
nanotechnology
therapy,
hoping
provide
new
directions
ideas
improve
Nanotechnology,
Год журнала:
2024,
Номер
35(46), С. 465102 - 465102
Опубликована: Авг. 15, 2024
Triple-negative
breast
cancer
(TNBC)
is
considered
the
most
aggressive
form
of
owing
to
negative
expression
targetable
bioreceptors.
Epithelial
mesenchymal
transition
(EMT)
associated
with
metastatic
abilities
its
critical
feature.
As
an
attempt
target
TNBC,
nanotechnology
was
utilised
augment
effects
drug
repurposing.
Concerning
that,
a
combination
therapeutic
module
structured
one
aspects
being
repurposed
antihistamine,
promethazine
hydrochloride
loaded
PLGA
nanoparticles.
The
as-synthesized
nanoparticles
were
217
nm
in
size
and
fluoresced
at
522
nm,
rendering
them
suitable
for
theranostic
applications
too.
second
feature
common
histone
deacetylase
inhibitor,
suberoylanilide
hydroxamic
acid
(SAHA),
used
as
pre-treatment.
Experimental
studies
demonstrated
efficient
cellular
internalisation
significant
innate
anti-proliferative
potential.
use
SAHA
sensitised
cells
nanoparticle
treatment.
Mechanistic
showed
increase
ROS
generation,
mitochondrial
dysfunction
followed
by
apoptosis.
Investigations
into
protein
also
revealed
reduction
proteins
like
vimentin
1.90
fold;
while
epithelial
marker
E-Cadherin
1.42
fold,
thus
indicating
altered
EMT
dynamics.
Further
findings
provided
better
insight
benefits
potentiated
targeting
tumor
spheroids
that
mimic
solid
tumors
TNBC.
Thus,
this
study
paves
avenue
more
rational
translational
validation
combining
nanotherapeutics
