Nanoformulation-assisted microneedle transdermal drug delivery system: An innovative platform enhancing rheumatoid arthritis treatment
Yao Wendong,
Yan Xingxing,
Xie Xianze
и другие.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117219 - 117219
Опубликована: Июль 30, 2024
A
transdermal
delivery
system
offers
high
bioavailability
and
favorable
patient
adherence,
constituting
an
optimal
approach
for
localized
administration
in
rheumatoid
arthritis
(RA)
treatment.
However,
the
stratum
corneum
(SC)
impedes
efficiency
of
conventional
drug
systems.
Microneedles
(MNs)
can
temporarily
create
micropores
within
SC,
enabling
distribution
via
bypassing
this
barrier
enhancing
effectiveness.
Notably,
MNs
provide
a
painless
method
through
skin
may
directly
modulate
inflammation
immune
cells
by
delivering
drugs
lymphatic
during
administration.
MN
is
not
suitable
with
low
water
solubility
stability.
Additionally,
major
concerns
exist
regarding
safety
using
highly
cytotoxic
drugs,
given
that
it
could
result
local
concentration
at
site.
While
exhibit
some
degree
targeted
to
inflammatory
environment,
their
targeting
remains
suboptimal.
Nanoformulations
have
potential
significantly
address
limitations
RA
treatment
improving
targeting,
solubility,
stability,
biocompatibility.
Therefore,
review
provides
concise
overview
advantages,
disadvantages,
mechanisms
different
types
It
specifically
focuses
on
application
advantages
combining
nanoformulation
summarizes
current
trends
development
nanoformulations
combined
field
treatment,
offering
theoretical
support
future
advancements
clinical
applications.
Язык: Английский
Innovative approaches to asthma treatment: harnessing nanoparticle technology
Discover Nano,
Год журнала:
2025,
Номер
20(1)
Опубликована: Фев. 8, 2025
In
the
domain
of
respiratory
illnesses,
asthma
remains
a
critical
obstacle.
The
heterogeneous
nature
this
chronic
inflammatory
disease
poses
challenges
during
its
treatment.
Glucocorticoid-based
combination
drug
therapy
now
dominates
clinical
treatments
for
asthma;
however,
glucocorticoid
resistance,
numerous
adverse
effects,
incidence
inadequate
delivery,
and
other
factors
need
development
more
effective
therapies.
recent
years,
there
has
been
extensive
research
on
nanotechnology
in
medicine.
It
shown
studies
that
these
delivery
systems
can
greatly
enhance
targeting
bioavailability
decrease
toxicity
medication.
Nanoparticle
offer
improved
therapeutic
efficacy
compared
to
conventional
administration
techniques.
Nanotechnology
enables
advancements
precision
medicine,
offering
benefits
conditions
such
as
asthma.
This
review
will
examine
consider
when
formulating
medications,
well
role
nanomaterials
their
mechanisms
action
pulmonary
medicine
Язык: Английский
Tolerogenic nanovaccines for the treatment of type I allergic diseases
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 664 - 685
Опубликована: Фев. 17, 2025
Язык: Английский
The H2S-releasing multifunctional composite ionic liquid facilitates topical melittin delivery for psoriasis treatment through RONS scavenging and inflammation inhibition
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160972 - 160972
Опубликована: Фев. 1, 2025
Язык: Английский
Drug-loaded microneedle patches containing regulatory T cell-derived exosomes for psoriasis treatment
Meitong Ou,
Jiahui Cao,
Ran Luo
и другие.
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Tough and waterproof microneedles overcome mucosal immunotolerance by modulating antigen release patterns
Journal of Controlled Release,
Год журнала:
2025,
Номер
382, С. 113740 - 113740
Опубликована: Апрель 16, 2025
Язык: Английский
A comprehensive overview of tolerogenic vaccine adjuvants and their modes of action
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 20, 2024
Tolerogenic
vaccines
represent
a
therapeutic
approach
to
induce
antigen-specific
immune
tolerance
disease-relevant
antigens.
As
general
immunosuppression
comes
with
significant
side
effects,
including
heightened
risk
of
infections
and
reduced
anti-tumor
immunity,
by
vaccination
would
be
game
changing
in
the
treatment
immunological
conditions
such
as
autoimmunity,
anti-drug
antibody
responses,
transplantation
rejection,
hypersensitivity.
promoting
tolerogenic
antigen
presenting
cells,
regulatory
T
B
or
suppressing
depleting
pathogenic
cells.
The
design
vary
greatly,
but
they
all
deliver
without
adjuvant.
adjuvants
are
molecules
which
mediate
anti-inflammatory
immunoregulatory
effects
enhance
vaccine
efficacy
modulating
environment
favor
response
antigen.
act
through
several
mechanisms,
immunosuppression,
modulation
cytokine
signaling,
vitamin
synapse
signaling.
This
review
seeks
provide
comprehensive
examination
currently
utilized
vaccines,
describing
their
mechanism
action
examples
use
human
clinical
trials
animal
models
disease.
Язык: Английский