Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 22, 2024
While
met
with
initial
and
ground-breaking
success
targeting
blood
borne
cancers,
cellular
immunotherapy
remains
significantly
hindered
in
the
context
of
solid
tumors
by
tumor
microenvironment.
Focused
ultrasound,
conjunction
microbubbles,
has
found
tremendous
potential
as
a
targeted
local
drug/gene
delivery
technique
for
cancer
therapy.
The
specific
immunomodulating
effects
this
on
immune
cells,
including
T-cells,
remain
unexplored.
Here,
freshly
isolated
human
we
examine
how
focused
ultrasound
can
viably
modulate
cell
membrane
permeability
influence
secretion
over
90
cytokines,
chemokines
other
analytes
relevant
to
potent
response
against
cancer.
We
determine
that
microbubble-mediated
modulates
secretome
time-dependent
manner
–
ranging
~0.1-3.6-fold
changes
concentration
given
cytokine
compared
sham
controls
48
hours
post-treatment
(
e.g.
IL-1β,
TNF-α,
CX3CL1,
CCL21).
Further,
general
trend
negative
correlation
between
secreted
viable
ultrasound-assisted
negligible
loss
viability.
Taken
together,
data
presented
here
highlights
enhance
T-cell
key
pro-immune
pathways,
offering
novel
approach
augment
therapies
tumors.
Cellular
immunotherapy
remains
hindered
in
the
context
of
solid
tumors
due
to
immunosuppressive
microenvironment,
which
key
endothelial
cell
adhesion
molecules
(CAM)
are
suppressed.
Microbubble‐mediated
focused
ultrasound
is
being
explored
for
targeted
and
can
exert
local
shear
stress
upon
neighboring
cells.
However,
fluid
microbubble‐induced
modulation
immunobiology
not
well
understood.
Herein,
influence
both
types
on
human
vein
(HUVEC)
brain
(HBEC‐5i)
CAM
expression
secretion
over
90
cytokines
using
acoustically
coupled
microscopy
examined.
Fluid
flow
results
time‐dependent
expression,
where
ICAM‐1
peaked
at
4
h
(1.98‐fold,
p
<
0.001,
HUVEC)
24
(1.56‐fold,
HBEC‐5i).
While
some
chemokines
significantly
enhanced
(up
16.2‐fold;
0.001)
from
(e.g.,
IL‐8,
MCP‐1,
MCP‐3),
others
differentially
expressed
CCL5,
CXCL‐16,
SDF‐1).
Under
ultrasound,
increased
(≈1.4‐fold,
0.01)
resulted
significant
large‐magnitude
(
0.05)
differential
20
cytokines,
most
have
immune‐activating
function
within
a
subset
those
induced
by
shear‐flow.
regulates
secretome
toward
an
immune
recruitment
paradigm,
thus
may
reinforce
tumor
cellular
efforts.
Cancers,
Год журнала:
2025,
Номер
17(7), С. 1211 - 1211
Опубликована: Апрель 2, 2025
Glioblastoma
(GBM)
remains
a
challenging
cancer
to
treat
with
limited
effective
therapies.
Standard
treatments,
including
surgery,
radiotherapy,
chemotherapy,
targeted
therapy,
and
immunotherapy,
offer
marginal
survival
benefits
but
are
often
by
side
effects
drug
resistance.
Temozolomide
is
the
most
commonly
used
chemotherapy;
however,
resistance
lack
of
efficacy
in
recurrent
GBM
hinder
its
success.
Tumor
treating
fields
(TTFields),
novel
non-invasive
modality
that
utilizes
alternating
electric
fields,
have
recently
emerged
as
promising
treatment
for
GBM.
TTFields
work
disrupting
function
mitotic
spindle
inducing
apoptosis
cells.
They
can
be
especially
when
combined
other
enhance
delivery
paired
chemotherapy
increasing
permeability
blood-brain
barrier
cell
membranes,
leading
more
tumor
inhibition.
Similarly,
increase
sensitivity
radiation
therapy
improve
therapies,
such
sorafenib
particularly
extra-cranial
tumors.
The
Optune
device,
primary
medical
device
TTFields'
delivery,
offers
convenient
versatile
option,
allowing
remote
care
exhibiting
fewer
adverse
effects.
This
review
discusses
potential
valuable
addition
treatment,
combination
highlights
device's
clinical
applications.
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Апрель 5, 2025
The
World
Health
Organization's
2021
classification
of
central
nervous
system
neoplasms
incorporated
molecular
and
genetic
features
for
classifying
gliomas.
Classification
gliomas
located
in
deep-seated
structures
became
a
clinical
conundrum
given
the
absence
crucial
pathological
data.
Advances
noninvasive
imaging
modalities
offered
virtual
biopsy
as
novel
solution
to
this
problem
by
identifying
surrogate
radiomic
signatures.
Liquid
biopsies
blood
or
cerebrospinal
fluid
provided
another
enormous
opportunity
genomic,
metabolomic
proteomic
We
summarize
appraise
current
state
evidence
with
regards
liquid
care
patients
PubMed,
Embase
Google
Scholar
were
searched
on
7/30/2024
relevant
articles
published
after
year
2013
English
language.
A
large
body
preclinical
preliminary
suggests
that
is
possible
combined
use
multiple
conjunction
machine
learning
radiomics.
Likewise,
focused
ultrasound
may
be
valuable
tool
obtain
genomic
data
regarding
glioma
minimally
invasive
manner.
These
will
likely
become
an
integral
part
future.
Journal of Analytical Science & Technology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 8, 2025
Abstract
Conventional
chemotherapy
is
often
constrained
by
the
toxic
effects
of
anticancer
drugs,
particularly
in
drug-resistant
tumours
requiring
high
doses
for
efficacy.
This
challenge
underscores
need
innovative
strategies
to
deliver
medications
effectively
while
minimizing
systemic
toxicity.
Ultrasound-assisted
drug
delivery
has
emerged
as
a
promising
approach,
enhancing
localized
concentrations,
thereby
improving
treatment
outcomes
and
reducing
side
effects.
principles
recent
advancements
ultrasound-assisted
are
highlighted.
The
article
also
describes
strategy
involving
use
ultrasound-responsive
carriers
(URCs)
vivo
synthesis.
These
URCs
can
transport
two
precursors
(prodrugs).
Targeted
ultrasound
exposure
triggers
release
prodrugs,
leading
local
synthesis
"parent
drug”
that
cytotoxic
malignant
cells.
In
addition,
HIFU
(high-intensity
focused
ultrasound)
magnetic
nanoparticles
binary
discussed
detail.
method
could
minimize
harm
healthy
tissues
organs,
significantly
efficacy
toxicity
targeted
outcomes.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Abstract
mRNA
therapy
is
a
promising
approach
in
oncology,
offering
innovative
applications
such
as
tumor
vaccines,
protein
replacement
therapy,
cell
and
gene
therapy.
However,
challenges
stability
delivery
efficiency
must
be
addressed.
Advances
system
technologies
are
crucial
for
precise
delivery,
enhancing
treatment
safety
efficacy.
The
development
of
systems
requires
accurate
organ
or
targeting,
intelligent
release
mechanisms,
optimized
administration
routes.
This
review
outlines
the
well
utilization
nonviral
vectors,
encompassing
organic,
inorganic,
biomimetic
systems.
It
further
elucidates
strategies
passive
active
vector
targeting
examines
recent
advances
realm
stimuli‐responsive
that
sensitive
to
pH
ultrasound.
Additionally,
addresses
noninvasive
designed
oral
pulmonary
administration.
current
emerging
trends
discussed,
potential
mitigate
these
issues
emphasized.
ECS Journal of Solid State Science and Technology,
Год журнала:
2024,
Номер
13(6), С. 067001 - 067001
Опубликована: Июнь 3, 2024
The
unique
properties
of
light
underlie
the
perspectives
quantum
photonic
technologies,
optical
interconnects,
and
a
wide
range
new
sensors.Some
most
dangerous
deadly
diseases
are
tumors,
cancers,
brain
lesions,
which
expensive
to
detect
treat.
Therefore,
low-cost
accurate
method
diagnose
them
can
prevent
treat
progress
this
disease.
In
work,
we
used
precise
topological
valley
crystal
(TVPC)
for
detection.
TVPC
is
an
important
transmitting
controlling
in
device.
valley-spin
locking
topology
state
provides
robust
transfer
low
propagation
loss
at
desired
path.In
order
design,
by
finding
edge
band
within
first
bulk
gap
146.4
THz–155.9
THz,
model
design
ring
resonator
(TRS)were
realized.
We
proposed
biosensorbyusing
hexagonal
lattice
air
holes
silicon
slab
with
compact
size
22.95
μ
m
×
10
m.
quality
factor
sensitivity
best
value
2.905
4
9021
nm
RIU
−1
respectively.
This
be
implemented
on
Complementary
Metal-Oxide-Semiconductor
(CMOS)
technology
as
high-sensitivity
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 22, 2024
While
met
with
initial
and
ground-breaking
success
targeting
blood
borne
cancers,
cellular
immunotherapy
remains
significantly
hindered
in
the
context
of
solid
tumors
by
tumor
microenvironment.
Focused
ultrasound,
conjunction
microbubbles,
has
found
tremendous
potential
as
a
targeted
local
drug/gene
delivery
technique
for
cancer
therapy.
The
specific
immunomodulating
effects
this
on
immune
cells,
including
T-cells,
remain
unexplored.
Here,
freshly
isolated
human
we
examine
how
focused
ultrasound
can
viably
modulate
cell
membrane
permeability
influence
secretion
over
90
cytokines,
chemokines
other
analytes
relevant
to
potent
response
against
cancer.
We
determine
that
microbubble-mediated
modulates
secretome
time-dependent
manner
–
ranging
~0.1-3.6-fold
changes
concentration
given
cytokine
compared
sham
controls
48
hours
post-treatment
(
e.g.
IL-1β,
TNF-α,
CX3CL1,
CCL21).
Further,
general
trend
negative
correlation
between
secreted
viable
ultrasound-assisted
negligible
loss
viability.
Taken
together,
data
presented
here
highlights
enhance
T-cell
key
pro-immune
pathways,
offering
novel
approach
augment
therapies
tumors.
