KAISO Promotes Poor Prognosis in Hepatocellular Carcinoma Patients by Enhancing Neutrophil Infiltration via IGFBP1
Abstract
Background
KAISO
is
a
transcriptional
regulator
involved
in
gene
expression,
cell
proliferation,
and
apoptosis,
linked
to
cancer
prognosis
tumor
aggressiveness,
making
it
potential
bi-omarker
therapeutic
target.
Methods:
We
used
bioinformatics
analyses
evaluate
expression
its
effect
on
survival
across
33
types
of
pan-cancer.
also
examined
the
link
between
immune
infiltration.
To
investigate
control
down-stream
proteins
by
KAISO,
we
dual-luciferase
reporter
assays,
electrophoretic
mobility
shift
assays
(EMSA),
chromatin
immunoprecipitation
(ChIP).
Additionally,
validated
role
regulating
infiltration
using
subcutaneous
model
animals
human
samples.
Results:
Our
research
revealed
that
crucial
growth
progression
various
malignancies,
including
hepatocellular
carcinoma
(HCC).
demonstrated
high
associated
with
poor
HCC.
was
found
regulate
transcription
IGFBP1
neutrophil
influence
HCC
pro-liferation
through
cycle-related
molecular
pathways.
Finally,
confirmed
reducing
can
inhibit
growth.
Conclusion:
findings
suggest
could
be
an
important
biomarker
target
for
patients.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Язык: Английский