Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110802 - 110802
Опубликована: Дек. 1, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101609 - 101609
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Molecular Medicine, Год журнала: 2025, Номер 31(1)
Опубликована: Март 12, 2025
Abstract X-linked Alport syndrome (XLAS) caused by COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of disrupted, suffer from life-threatening renal disease, mechanism which remains unclear. Renal fibrosis characteristic pathology observed in kidney tissue. However, molecular path loss-of-function to fibrotic largely unknown. On basis previously established mouse model, our study revealed an activated CD44-TGFβ signaling known strongly promote fibrosis, along with increased level low weight hyaluronan (LMW-HA) instead high (HMW-HA), activate CD44-dependent TGFβ tissues. Additionally, synthase 2 (HAS2), enzyme primarily responsible for HA production, was found be upregulated XLAS. In particular, vitro studies knockdown human kidney-derived HEK-293 cells can upregulate HAS2 at both RNA and protein levels. The novel contribution finding deficiency may lead overexpression accumulation signaling, thereby promoting possibly suggesting CD44 are potential therapeutic targets impeding
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 26, 2025
Activation of cGAS-STING signaling pathway and accumulation reactive oxygen nitrogen species (RONS) are important issues facing the treatment rheumatoid arthritis (RA). Here, we report a biomimetic nano-Chinese medicine (HA-RM-Cel-BR) for RA immunotherapy based on STING inhibition celastrol (Cel) RONS clearance bilirubin (BR). HA-RM-Cel-BR is constructed by carrier-free self-assembly active ingredients Cel BR from traditional Chinese medicine, then camouflaged hyaluronic acid (HA)-modified red blood cell membranes (RM). prolongs circulation time through RM camouflage, targets inflamed joints HA modification, remodels joint immune microenvironment clearance. More importantly, shows excellent therapeutic effects rat model, significantly reduces hepatotoxicity associated with Cel. Our work provides new strategy ingredients.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113258 - 113258
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(45), С. 62693 - 62709
Опубликована: Ноя. 4, 2024
Acute kidney injury (AKI) is a dynamic process associated with inflammation, oxidative stress, and lipid peroxidation, in which mitochondrial mitophagy macrophage polarization play critical role the pathophysiology. Based on expression of CD44 receptor renal tubular epithelial cells (RTECs) activated M1 macrophages being abnormally increased, accompanied by up-regulation reactive oxygen species (ROS) during AKI, conjugates bilirubin (BR), an endogenous antioxidant has property anti-inflammation, chondroitin sulfate (CS) CD44-targeting could be promising therapeutic carrier. In this study, we develop CD44-targeted/ROS-responsive CS-BR-mediated multifunctional liposome loading celastrol (CS-BR@CLT) for targeted therapy AKI. CS-BR@CLT shown to selectively accumulate AKI mouse kidneys via targeting receptors. Treatment significantly ameliorates acute caused ischemia-reperfusion protects function. Mechanistically, inhibits apoptosis, mitochondria, promotes autophagy, regulates polarization, alleviates interstitial inflammation. Overall, our study demonstrates that strategy ameliorate injury.
Язык: Английский
Процитировано
2
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)
Опубликована: Авг. 18, 2024
Pulmonary hypertension (PH) is a life-threatening cardiovascular disease with lack of effective treatment options. Nanozymes, though promising for PH therapy, pose safety risks due to their metallic nature. Here, non-metallic nanozyme reported the monocrotaline (MCT)-induced therapeutic mechanism involving ROS/TGF-β1 signaling. The synthesized melanin-polyvinylpyrrolidone-polyethylene glycol (MPP) nanoparticles showcase ultra-small size, excellent water solubility, high biocompatibility, and remarkable antioxidant capacity. MPP are capable effectively eliminating ROS in isolated pulmonary artery smooth muscle cells (PASMCs) from rats, significantly reduce PASMC proliferation migration. In vivo results model demonstrate that increase acceleration time, decrease wall thickening PCNA expression lung tissues, as evidenced by echocardiograpy, histology immunoblot analysis. Additionally, improve running capacity, Fulton index, attenuate right ventricular fibrosis MCT-PH rats using treadmill test, picrosirius red, trichrome Masson staining. Further transcriptomic biochemical analyses reveal inhibiting ROS-driven activation TGF-β1 PA which exert effect. This study provides novel approach treating nanozymes based on well-understood mechanism.
Язык: Английский
Процитировано
1
Cell Stress and Chaperones, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
1
Burns & Trauma, Год журнала: 2024, Номер 12
Опубликована: Янв. 1, 2024
Abstract Acute kidney injury (AKI), a common disease in which renal function decreases rapidly due to various etiologic factors, is an important risk factor for chronic (CKD). The pathogenesis of AKI leading CKD complex, and effective treatments are still lacking, seriously affects the prognosis quality life patients with disease. Nanomedicine, discipline at intersection medicine nanotechnology, has emerged as promising avenue treating diseases ranging from CKD. Increasing evidence validated therapeutic potential nanomedicine AKI; however, little attention been paid its effect on In this review, we systematically emphasize major pathophysiology AKI-to-CKD transition summarize treatment effects transition. Furthermore, discuss key role regulation targeted drug delivery, inflammation, oxidative stress, ferroptosis, apoptosis during Additionally, review demonstrates that integration into nephrology offers unprecedented precision efficacy management conditions CKD, including design preparation multifunctional nanocarriers overcome biological barriers deliver therapeutics specifically cells. summary, holds significant revolutionizing transition, thereby providing opportunity future diseases.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 282 - 296
Опубликована: Дек. 20, 2024
Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts iron ions from excess myoglobin in kidneys, which mediates overproduction reactive species with onset overload via Fenton reaction, thus inducing ferroptosis and leading to renal dysfunction. Unfortunately, there are no effective treatments for AKI other than supportive care. Herein, we developed a multifunctional nanoplatform (MPD) by covalently bonding melanin nanoparticles (MP NPs) deferoxamine. The has good dispersion physiological stability, excellent chelating performance ions, broad-spectrum scavenging activity. Furthermore, cellular experiments showed that NPs possessed high biocompatibility, antiapoptotic activity, antioxidant properties, strong capacity Fe2+ mitigate overload, protecting intracellular mitochondria oxidative stress. Meanwhile, intrinsic photoacoustic imaging capability allows real-time monitoring MPD NPs' target uptake metabolic behavior healthy mice. Most importantly, led downregulation pathway targeting ferroptosis, effectively rescuing function vivo, mitigating stress inflammatory responses, inhibiting tubular cell apoptosis. offers novel therapeutic strategy RM-induced AKI.
Язык: Английский
Процитировано
1
Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110802 - 110802
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0