Biomimetic Nanoparticles for Targeted Therapy of Liver Disease

RSC Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Liver fibrosis is a progressive and fatal condition characterized by stiffness scarring of the liver due to excessive buildup extracellular matrix (ECM) proteins. If left untreated, it can progress cirrhosis hepatocellular carcinoma (HCC)-one fastest-rising causes cancer mortality in United States. Despite increased prevalence infections, exposure toxins, unhealthy lifestyles, there are no effective treatments available. Recent advances nanomedicine lead more targeted strategies for treating diseases than existing treatments. In particular, use biomimetic nanoparticles (NPs) such as liposomes cell-membrane-coated NPs interest. functionalized with cell membranes mimic properties source used provide inherent immune evasion ability, homologous adhesion, prolonged circulation. This review explores types coatings, different cargoes delivered through various treatment modalities, type core targeting HCC.

Язык: Английский

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Recent advances in exploring the properties and applications of hyaluronan

Deleted Journal, Год журнала: 2024, Номер 1(3), С. 100039 - 100039

Опубликована: Авг. 27, 2024

Hyaluronan (HA) is a naturally occurring polysaccharide in the organism. As one of main components extracellular matrix, it plays an important role regulating various cellular processes, including proliferation, differentiation, inflammation, and immunity, through interaction with HA receptors. widely found human body, particularly skin joints, thus playing crucial functioning these tissues. The aging occurrence osteoarthritis are related to loss HA. Supplementing appropriate areas can delay or prevent processes. Common methods supplementation include topical application injection into joint cavities, both which have shown efficacy restoring levels improving tissue function. In recent years, studies that oral administration also similar effects. Oral first passes gastrointestinal tract then enters liver blood circulation. Therefore, addition supplementing content exert beneficial effects on liver, such as enhancing barrier function tract, intestinal flora, reducing inflammation. Supplementation has numerous benefits for skin, orthopedic disorders, liver. understand mechanisms exerts This article describes basic properties reviews its relationship diseases, well applications areas.

Язык: Английский

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 318 - 336

Опубликована: Окт. 18, 2024

Язык: Английский

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Sequential system based on ferritin delivery system and cell therapy for modulating the pathological microenvironment and promoting recovery

International Journal of Pharmaceutics, Год журнала: 2024, Номер 664, С. 124607 - 124607

Опубликована: Авг. 17, 2024

Язык: Английский

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Dual-targeting galactose-functionalized hyaluronic acid modified lipid nanoparticles delivering silybin for alleviating alcoholic liver injury

International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124662 - 124662

Опубликована: Сен. 4, 2024

Язык: Английский

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The nanocrystal-loaded liposome of tanshinone IIA with high drug loading and stability towards efficient liver fibrosis reversion

Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер 63, С. 102797 - 102797

Опубликована: Ноя. 27, 2024

Язык: Английский

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