Materials Today Bio, Год журнала: 2024, Номер 29, С. 101358 - 101358
Опубликована: Ноя. 23, 2024
Язык: Английский
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер 1880(2), С. 189285 - 189285
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 470 - 483
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
6
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 1, 2025
ABSTRACT Iron‐based nanomaterials (IBNMs) have been widely applied in biomedicine applications including magnetic resonance imaging, targeted drug delivery, tumor therapy, and so forth, due to their unique magnetism, excellent biocompatibility, diverse modalities. Further research on its enormous biomedical potential is still ongoing, new features are constantly being tapped demonstrated. Among them, various types of IBNMs demonstrated significant cancer therapy capabilities by regulating the microenvironment (TME). In this review, a variety iron oxide‐based (IONMs), iron‐based complex conjugates (ICCs), single atom (ISANMs) will be introduced, advantages TME would also emphasized. Besides, recent progress for diagnosis treatment through strategy modulating summarized, overcoming hypoxia, acidity, decreasing redox species, immunoregulation. Finally, challenges opportunities field briefly discussed. This review expected contribute future design development next‐generation TME‐modulate treatment.
Язык: Английский
Процитировано
0
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Abstract Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its immunosuppressive microenvironment and the immune privilege. Immunotherapy activating system T lymphocyte infiltration holds great promise against GBM. However, brain’s low immunogenicity difficulty of crossing blood-brain barrier (BBB) hinder therapeutic efficacy. Recent advancements in immune-actuated particles for targeted drug delivery have shown potential overcome these obstacles. These interact with BBB by rapidly reversibly disrupting structure, thereby significantly enhancing targeting penetrating delivery. The also minimizes long-term damage. At GBM, demonstrated effective chemotherapy, chemodynamic therapy, photothermal therapy (PTT), photodynamic (PDT), radiotherapy, or magnetotherapy, facilitating tumor disruption promoting antigen release. Additionally, components retained autologous tumor-associated antigens presented them dendritic cells (DCs), ensuring prolonged activation. This review explores mechanisms existing strategies, role nanomaterials immunotherapy. We discuss innovative particle-based approaches designed traverse mimicking innate functions improve outcomes tumors. Graphical
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 14
Опубликована: Янв. 13, 2025
Background Ferroptosis is a cell death mode caused by excessive accumulation of lipid peroxides disturbance intracellular metabolic pathway, which closely related to iron and cholesterol metabolism homeostasis. Its regulation within the hypoxic tumor microenvironment (TME) has potential improve effectiveness immunotherapy. The predictive role ferroptosis in gastric cancer (GC) hypoxia TME, particularly relation TME immune infiltration, not been fully explained. Methods By analyzing mRNA expression data hypoxia-related genes, prediction model was constructed evaluate further value clinical characteristics, immunotherapy efficacy cancer, essential genes were validated. Results Two distinct molecular states ferroptosis-hypoxia identified GC. Notably, patients with high risk scores (FHRS) displayed significant levels epithelial-mesenchymal transition (EMT), associated unfavorable prognosis, increased chemoresistance, heightened immunosuppression. Conclusions This study demonstrates that under conditions significantly affects modulation microenvironment. FHRS can independently predict prognosis cancer. Assessing status individual will help selecting more suitable regimens providing better understanding characteristics predicting immunotherapeutic outcomes.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101530 - 101530
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1752 - 1752
Опубликована: Фев. 19, 2025
Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.
Язык: Английский
Процитировано
0
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 8 - 8
Опубликована: Март 7, 2025
Photodynamic and photothermal therapies with IR780 have gained exponential interest, their photophysical properties demonstrated promise for use in antitumor antimicrobial chemotherapy. its derivatives are valuable labeling nanostructures different chemical compositions vitro vivo fluorescence monitoring studies the near-infrared (NIR) spectrum. The current literature is abundant on this topic, particularly applications treatment of types cancer using laser illumination to produce photodynamic (PDT), (PTT), and, more recently, sonodynamic therapy (SDT) approaches cell death. This review aims update state art concerning photosensitizer as a theranostic agent PDT, PTT, SDT, photoacoustic (PA) effects, imaging associated nanocarriers. concerns period from 2017 2024, considering, specifically, effects found preclinical experiments. Some aspects stability nanostructured systems will be discussed based evidence leakage nanocarrier consequences reliable analysis biological data.
Язык: Английский
Процитировано
0
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104691 - 104691
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(7), С. 7239 - 7257
Опубликована: Июль 8, 2024
Photodynamic therapy (PDT) can not only directly eliminate cancer cells, but also stimulate antitumor immune responses. It affects the expression of checkpoints. The purpose this review is to collect, analyze, and summarize recent news about PDT checkpoints, along with their inhibitors, identify future research directions that may enhance effectiveness approach. A search for articles published between January 2023 March 2024 was conducted in PubMed/MEDLINE. Eligibility criteria were as follows: (1) papers describing (2) original papers, (3) new reports field (4) both vitro vivo papers. Exclusion included written a language other than Polish or English, before 2023. 24 data on checkpoints have been since These information effects attempts associate ICI molecules modulate improve immunosuppressive environment tumor, resolve PDT-related problems. They focused development nanoparticles delivery photosensitizers drugs selectively tumor. effect level associated activity system has fully elucidated further, area are divergent, indicating complexity interaction system. PDT-based strategies shown beneficial utility enhancing induction response by participating triggering immunogenic cell death, exposure tumor antigens, release various alarm signals together promote activation dendritic cells components demonstrated, result induced therapy. enables multifaceted regulation tumor’s environment, which potential achieve better efficacy. current presented evidence PDT’s ability association ICIs inducing an effective against cells. However, these studies at early stage many more observations need be made confirm indicated contribute further strategies.
Язык: Английский
Процитировано
3