Design and biomedical application of Cr3+-doped gallate near-infrared persistent luminescence nanoprobes

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159183 - 159183

Опубликована: Янв. 5, 2025

Язык: Английский

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Drug delivery for platinum therapeutics

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 503 - 523

Опубликована: Фев. 11, 2025

Язык: Английский

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Supramolecular charge-reversal pillar[6]arenes-oxaliplatin system for cancer therapy with reduced toxicity and enhanced efficacy

Journal of Industrial and Engineering Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137479 - 137479

Опубликована: Март 1, 2025

Язык: Английский

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Quantification of Cisplatin Encapsulated in Nanomedicine: An Overview

Biosensors, Год журнала: 2025, Номер 15(5), С. 293 - 293

Опубликована: Май 6, 2025

Cisplatin, which kills cancer cells mainly through DNA crosslinking, has been widely used as a first-line chemotherapeutic agent although it also causes severe side effects. To improve anticancer outcomes, various types of cisplatin-based nanomedicines have developed, either direct incorporation or coordination cisplatin within nanoparticles (NPs). During the formulation and characterization cisplatin-loaded NPs, quantitative determination is crucial for both clinically newly developed NPs. While NPs facilitate delivery, use different nanomaterials inevitably complicates its increases cost quantification. Currently, there still significant demand an accurate, simple, cost-effective method to determine in would screening quality control nanomedicines. This review aims discuss main strategies quantifying cisplatin, following summary Application examples are provided, key features each quantification strategy compared. In addition, NP-based electrochemical sensors included emerging approach characterizing loaded Rational selection appropriate according principle specific drug-delivery settings highly recommended.

Язык: Английский

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Bone marrow microenvironment-targeted yolk-shell nanoparticle enhances acute myeloid leukemia chemotherapy by preventing endothelial cell/ECM-mediated adhesion

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164084 - 164084

Опубликована: Май 1, 2025

Язык: Английский

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Synthesis and In Vitro Bioactivity of Symmetrical Enediynes Based on Maleimide and Propargylamides

ChemistrySelect, Год журнала: 2025, Номер 10(21)

Опубликована: Май 28, 2025

Abstract Natural enediynes, characterized by the (Z)‐1,5‐diyn‐3‐ene core, are among most potent antitumor agents, functioning through DNA‐damaging diradicals generated via Bergman or Myers–Saito cyclization. Despite their promising therapeutic potential, clinical application is limited due to scarcity. To address this limitation, we developed a new class of symmetrical maleimide‐based acyclic enediynes featuring propargylamide moieties, which exhibit excellent thermal reactivity maleimide‐assisted rearrangement and cycloaromatization mechanism. These compounds demonstrated high efficiency in generating biradicals at physiological temperatures, as confirmed electron paramagnetic resonance (EPR) analysis. Additionally, vitro assays revealed DNA cleavage ability significant cytotoxicity against tumor cells, with half‐maximal cytotoxic concentrations (CC 50 ) low 1.98 µM. Confocal laser scanning microscopy indicated substantial cellular uptake damage HeLa cells. Our findings underscore potential these novel targeted cancer therapy, positioning them candidates for both traditional chemotherapy antibody‐drug conjugate (ADC) payloads.

Язык: Английский

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Vascular-Targeted Nanoplatform for Enhanced Immunotherapy via Synergistic Thrombosis and Hypoxia-Activated Chemotherapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 30, 2025

Tumor vasculature plays a crucial role in sustaining cancer progression, making vascular-targeted strategies highly promising for therapy. Herein, we develop nanoplatform (ThT@ZRR) that synergistically integrates thrombin-induced thrombosis with hypoxia-activated chemotherapy to amplify antitumor immunity. ThT@ZRR consists of thrombin and tirapazamine (TPZ) coloaded within ZIF-8 nanoparticles cloaked by RGD-modified red blood cell membranes. Upon tumor accumulation, pH-responsive release induces localized thrombosis, disrupting flow exacerbating hypoxia, which, turn, enhances TPZ activation. This cascade not only direct killing but also triggers robust immune responses. The combined effects thrombosis-induced inflammatory signals TPZ-mediated immunogenic death promote dendritic maturation, CD8+ T-cell infiltration, pro-inflammatory macrophage polarization, fostering microenvironment conducive Notably, exhibited potent efficacy murine melanoma (B16F10) triple-negative breast (4T1) models distinct vascular architectures, highlighting its adaptability heterogeneous microenvironments. By integration embolization, chemotherapy, synergistic thrombosis- ICD-driven activation, this offers strategy enhancing immunotherapy overcoming resistance solid tumors.

Язык: Английский

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Hyaluronic acid-coated Zein Nanoparticle-Mediated Resveratrol Therapy for the Reduction of Cisplatin-Associated Nephrotoxicity

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 736, С. 150873 - 150873

Опубликована: Окт. 23, 2024

Язык: Английский

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LncRNA-Mediated Regulation of Cisplatin Response in Breast Cancer

Pathology - Research and Practice, Год журнала: 2024, Номер 264, С. 155716 - 155716

Опубликована: Ноя. 7, 2024

Язык: Английский

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