Magnetic Field Driven Ceria Nanosystems for Mitochondria Targeted Therapy of Ischemic Stroke

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Nanomedicine based brain targeting strategies have emerged as a promising avenue for ischemic stroke (IS) treatment. However, conventional approaches face significant challenges in manipulating biodistribution and achieving efficient to attain adequate therapeutic effects. Here, this limitation is overcame by developing magnetic field driven, mitochondria‐targeted ceria nanosystem (MMTCe) nanosystem. By anchoring nanoparticles the cell membrane, targeted delivery of achieved through use an external field, which turn targets damaged mitochondria repairs microenvironment. MMTCe exhibits superior accumulation within vitro blood barrier (BBB) model rat stroke. This mediates mitochondrial function, thereby inhibiting oxidative stress aberrant activation microglial cells, ultimately inducing rebalancing Complemented favorable biosafety profile, top‐down fabrication provides general strategy diseases informs development magnetically driven systems.

Язык: Английский

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Leveraging nature’s nanocarriers: Translating insights from extracellular vesicles to biomimetic synthetic vesicles for biomedical applications

Science Advances, Год журнала: 2025, Номер 11(9)

Опубликована: Фев. 26, 2025

Naturally occurring extracellular vesicles (EVs) and synthetic nanoparticles like liposomes have revolutionized precision diagnostics medicine. EVs excel in biocompatibility cell targeting, while offer enhanced drug loading capacity scalability. The clinical translation of is hindered by challenges including low yield heterogeneity, whereas face rapid immune clearance limited targeting efficiency. To bridge these gaps, biomimetic (SVs) emerged as innovative platforms, combining the advantageous properties liposomes. This review emphasizes critical aspects EV biology, such mechanisms EV-cell interaction source-dependent functionalities modulation, tissue regeneration, informing SV engineering. We reviewed a broad array SVs, with focus on lipid bilayered functionalized proteins. These include cell-derived nanovesicles, protein-functionalized liposomes, hybrid vesicles. By addressing current highlighting opportunities, this aims to advance SVs for transformative biomedical applications.

Язык: Английский

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Nanoparticles Designed Based on the Blood‐Brain Barrier for the Treatment of Cerebral Ischemia‐Reperfusion Injury

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Cerebral ischemia-reperfusion injury (CI/RI) is currently considered a significant factor affecting the prognosis of ischemic stroke. The blood-brain barrier (BBB) plays multiple roles in treatment ofCI/RI. BBB leakage allows bloodborne toxins to exacerbate stroke pathology. Yet as physiological that separates blood from brain, also poses obstacle therapeutic drug delivery. Therefore, it essential consider both crossing and repairing process CI/RI. Leveraging exceptional benefits nanoparticles (NPs) for penetration targeted repair, numerous NPs are developed promising delivery platforms. Considering complex role CI/RI, this review delves into strategies designing cross BBB, focusing on peptide-modified NPs, cell-mediated cell membrane-derived BBB-modulating NPs. Additionally, summarizes design targeting endothelial cells (ECs), astrocytes, those aimed at regulating microenvironment repair BBB. On basis, reveals prospects challenges designed around CI/RI treatment. And highlights need combine permeability promotion nanoparticle based achieve more effective

Язык: Английский

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PI3K/AKT Pathway: A Potential Therapeutic Target in Cerebral Ischemia-Reperfusion Injury

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177505 - 177505

Опубликована: Март 1, 2025

Язык: Английский

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Cryptotanshinone-loaded biomimetic pH-sensitive liposomes for the treatment of liver fibrosis

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106496 - 106496

Опубликована: Дек. 1, 2024

Язык: Английский

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