Extracellular Matrix-Inspired Dendrimer Nanogels Encapsulating Cyclophosphamide for Systemic Sclerosis Treatment

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Cyclophosphamide has a certain therapeutic effect on treating systemic sclerosis (SSc), while difficulties exist in controlling severe systematic side effects and enhancing targeting capacity. Here, inspired from the natural extracellular matrix composition, we propose cyclophosphamide-encapsulated nanogel based dendritic polymers polyamidoamine (PAMAM) for SSc treatment. We combine bovine serum albumin generation 5 (G5) PAMAM dendrimers with polyphenol modification to obtain nanogels featured antioxidant anti-inflammatory effects. The can possess excellent biocompatibility prevent fibroblasts oxidative stress damage TGF-β-mediated activation. Furthermore, bleomycin-induced mouse model, dendrimer encapsulating cyclophosphamide also exhibit ability attenuate fibrosis by modulating immunity, suppressing inflammation, reducing collagen synthesis. These findings underscore value of this polymer treatment chronic SSc, indicating its broader potential clinical applications.

Язык: Английский

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Ultrasound-Driven Nitric Oxide Generation for Enhanced Sonodynamic–Photothermal Therapy

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Recently, green gas therapy based on nitric oxide (NO) has gained considerable attention in cancer treatment. The supplementation of exogenous NO and its controlled release represent promising strategies for adjuvant tumor therapy. In this study, we developed a novel ultrasound (US)-triggered generation nanoplatform that integrates therapy, sonodynamic photothermal (PTT) into collaborative therapeutic modality. An environmentally friendly biomacromolecule, polydopamine, was employed to coload chlorin e6 (Ce6) donor (BNN6), resulting the nanocomposite PDA-Ce6/BNN6 (PCB). A single US stimulus simultaneously activated Ce6 produce reactive oxygen species (ROS) promoted BNN6 NO. dual effects ultrasonic mechanical action physiological modulation by substantially improved local vascular function enhanced cell permeability, thereby increasing targeted accumulation PCB within tumors. Reactive nitrogen (RNS) derived from ROS further exacerbated oxidative damage sensitivity cells hyperthermia. Both vitro vivo experiments demonstrated stimulation NO/ROS/RNS combined with PTT effectively inhibited growth proliferation. findings suggest extracorporeal can significantly amplify efficacy offer new insights developing other aimed at physically regulating deep

Язык: Английский

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Ph/Gsh Dual-Responsive Janus-Type Au@H-Mp@Dox Mr Molecular Imaging Nanomotor for Combined Photothermal/Chemotherapeutic Treatment of Pancreatic Cancer

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanomolecular machines: Pioneering precision medicine for neoplastic diseases through advanced diagnosis and treatment

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(8), С. 167486 - 167486

Опубликована: Авг. 30, 2024

Язык: Английский

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A highly permeable nanoplatform based on functionalized carbon dots for synergistic reactive oxygen/nitrogen species tumor therapy

Materials Today Nano, Год журнала: 2024, Номер unknown, С. 100532 - 100532

Опубликована: Окт. 1, 2024

Язык: Английский

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