The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

и другие.

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 4 - 22

Опубликована: Дек. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Язык: Английский

Metal-Bearing Nanomaterials for Oral Antibacteria: Mechanisms and Applications DOI Creative Commons

Ke Quan,

Yuqing Zeng, Sijia Gao

и другие.

Advanced Sensor and Energy Materials, Год журнала: 2025, Номер unknown, С. 100141 - 100141

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Intracellular in-situ activated enzyme/prodrug strategy based on tris(triazole)-Cu+ complex for cooperative catalytic cancer therapy DOI

Tian Qiu,

Lan Yang,

Yupeng Zhu

и другие.

Nano Today, Год журнала: 2025, Номер 62, С. 102715 - 102715

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0
A Comprehensive Review on Stimuli-Responsive Nanomaterials: Advancements in Wound Healing and Tissue Regeneration DOI

M. Bellarmin,

J. Nandhini,

Karthikeyan Elumalai

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

Процитировано

0
Applications of smart responsive nanomaterials in the theranostics of gastrointestinal malignancies: Current status and future perspectives DOI
Wenpeng Huang,

Jingwei Zhou,

Yutong Liang

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216641 - 216641

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
Effects of Bare and PEG Coated Gold Nanoparticles on RRM2 Protein: A Pathway Analysis and MD Simulations Approach DOI
Ajit Kumar Singh, Anupam Nath Jha

BioNanoScience, Год журнала: 2025, Номер 15(2)

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
Application of magnetic aldehyde-functionalized ionic liquids for immobilization of acetylcholinesterase DOI

Mingxin Dong,

Yikang Shu,

Ran Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143101 - 143101

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures DOI Creative Commons
Dalton Bermudez, Thomas Lilieholm, Walter F. Block

и другие.

Journal of Magnetic Resonance Imaging, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, rare neurologic disorder where genetic mutation prevents dopamine production brain. Affected children fail to develop normal motor cognitive functions. MRI‐guided intraparenchymal delivery of AADC localized gray matter regions—specifically substantia nigra ventral tegmental area—has enabled brain produce dopamine, resulting dramatic improvements physical outcomes. The need target only small region simplifies surgical approach. However, broader neurodegenerative conditions has progressed more slowly than expected, despite significant global investment. Clinical efficacy depends heavily on accurate therapeutics via direct infusion, cerebrospinal fluid (CSF) administration, or both. Inadequate image guidance during clinical trials makes it difficult distinguish between true drug inefficacy failure. We highlight how increasing use MRI pre‐surgical simulation real‐time monitoring is accelerating development neurological diseases. This manuscript explores MRI's role guiding delivery, particularly using Convection Enhanced Delivery (CED). contributes across treatment timeline—from planning infusion validating therapeutic coverage. describe supports controlled distribution treatments its potential enable distributions needed correcting widespread anomalies. also detail structural anatomical sequences (T1, T2, Time Flight, Diffusion Tensor Imaging (DTI)) can help model likely distributions. Finally, we provide an outlook advanced DTI‐based algorithms poroelastic theory could further improve modeling dynamics. Current MRI‐based technologies be integrated enhanced CED effectiveness, especially very young pediatric patients. Evidence Level 1. Technical Efficacy Stage 4.

Язык: Английский

Процитировано

0
The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

и другие.

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 4 - 22

Опубликована: Дек. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Язык: Английский

Процитировано

1