Evaluating Mg2⁺- doped Cu-Zn ferrite nanoparticles for hyperthermia and their biocompatibility in normal and cancer cells
Ceramics International,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advancing Cancer Drug Delivery with Nanoparticles: Challenges and Prospects in Mathematical Modeling for In Vivo and In Vitro Systems
Cancers,
Год журнала:
2025,
Номер
17(2), С. 198 - 198
Опубликована: Янв. 9, 2025
Mathematical
models
are
crucial
for
predicting
the
behavior
of
drug
conjugate
nanoparticles
and
optimizing
delivery
systems
in
cancer
therapy.
These
simulate
interactions
among
nanoparticle
properties,
tumor
characteristics,
physiological
conditions,
including
resistance
targeting
specificity.
However,
they
often
rely
on
assumptions
that
may
not
accurately
reflect
vivo
conditions.
In
vitro
studies,
while
useful,
fully
capture
complexities
environment,
leading
to
an
overestimation
nanoparticle-based
therapy
effectiveness.
Advancements
mathematical
modeling,
supported
by
preclinical
data
artificial
intelligence,
vital
refining
therapies
improving
their
translation
into
effective
clinical
treatments.
Язык: Английский
Natural bimolecular system consisting of quercetin and ellagic acid enhances phototherapy
Materials Letters,
Год журнала:
2025,
Номер
unknown, С. 138275 - 138275
Опубликована: Фев. 1, 2025
Язык: Английский
Synergistic approach of PEGylated photothermal agent and immunomodulator in cancer immunotherapy
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Апрель 11, 2025
Photothermal
therapy
(PTT)
utilizes
photothermal
agents
(PTAs)
to
generate
heat
at
the
local
tumor
site
that
leads
ablation
upon
photoirradiation
a
specific
wavelength
of
light.
Currently,
most
available
PTAs
have
weak
selectivity
and
depositing
ability,
which
poor
therapeutic
outcomes.
PEGylation
improves
outcomes,
prolongs
systemic
circulation
time,
enhances
accumulation,
reduces
risk
clearance
by
immune
system.
This
paper
reviews
recent
developments
PEGylated
in
cancer
from
2019
2023,
highlighting
their
antitumour
efficacy
response
post-therapy
with
agents,
current
challenges
strategies.
review
aims
foster
knowledge
dissemination
on
application
nanomedicine
an
immunological
perspective
encourage
clinical
translation
these
nanomaterials.
Язык: Английский
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13302 - 13302
Опубликована: Дек. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Язык: Английский
Nanoparticle accumulation and penetration in 3D tumor models: the effect of size, shape, and surface charge
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 24, 2025
Preclinical
studies
have
demonstrated
that
nanoparticles
(NPs)
hold
significant
potential
for
advancing
cancer
therapy
by
enhancing
therapeutic
efficacy
while
reducing
side
effects.
Their
effectiveness
in
solid
tumors
is,
however,
often
constrained
insufficient
accumulation
and
penetration.
Understanding
how
the
physicochemical
properties
of
NPs
–
such
as
size,
shape,
surface
charge
influence
their
interaction
with
cells
within
tumor
is
critical
optimizing
NP
design.
In
this
study,
we
addressed
challenge
inconsistent
behavior
systematically
evaluating
uptake
both
2D
3D
models,
penetration
spheroids.
Our
results
showed
larger
exhibited
higher
internalization
rates
models
but
limited
Furthermore,
negatively
charged
consistently
achieved
superior
deeper
than
neutral
positively
NPs.
Spherical
outperformed
rod-shaped
These
findings
underscore
importance
carefully
tailoring
to
complex
microenvironment
improved
outcomes
real
tumors.
Язык: Английский
Current Research in Drug-Free Cancer Therapies
Akshaya Andavar,
Varsha Rajesh Bhagavathi,
J Cousin
и другие.
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 341 - 341
Опубликована: Март 26, 2025
Cancer
treatment
has
historically
depended
on
conventional
methods
like
chemotherapy,
radiation,
and
surgery;
however,
these
strategies
frequently
present
considerable
limitations,
including
toxicity,
resistance,
negative
impacts
healthy
tissues.
In
addressing
challenges,
drug-free
cancer
therapies
have
developed
as
viable
alternatives,
utilizing
advanced
physical
biological
to
specifically
target
tumor
cells
while
reducing
damage
normal
This
review
examines
several
strategies,
such
high-intensity
focused
energy
beams,
nanosecond
pulsed
electric
fields,
photothermal
therapy
well
the
use
of
inorganic
nanoparticles
promote
selective
apoptosis.
We
also
investigate
significance
targeting
microenvironment,
precision
medicine,
immunotherapy
in
progression
personalized
therapies.
Although
approaches
demonstrate
significant
promise,
challenges
scalability,
safety,
regulatory
obstacles
must
be
resolved
for
clinical
application.
paper
presents
an
overview
current
research
therapies,
emphasizing
recent
advancements,
underlying
scientific
principles,
steps
required
implementation.
Язык: Английский
Heterogeneity of tumor biophysical properties and their potential role as prognostic markers
Опубликована: Дек. 19, 2024
Progress
in
our
knowledge
of
tumor
regulatory
mechanisms
and
complexity
led
to
the
understanding
physical
parameters
cancer
cells
their
microenvironment,
including
mechanical,
thermal,
electrical
properties,
solid
stress,
liquid
pressure,
as
critical
regulators
progression
potential
prognostic
markers
associated
with
clinical
outcomes.
The
biological
hallmarks
abnormalities
tumors
are
mutually
reinforced,
promoting
a
vicious
cycle
progression.
A
comprehensive
analysis
is
for
developing
more
robust
diagnostic
improving
treatment
efficiency.
Like
traits,
features
characterized
by
inter-
intratumoral
heterogeneity.
dynamic
changes
properties
during
result
highlight
necessity
spatial
temporal
settings.
This
review
focuses
on
basis
tumor-specific
state-of-the-art
methods
analyses,
perspective
translation.
importance
disease
therapy
resistance,
well
current
strategies
monitor
target
traits
clinics,
highlighted.
Язык: Английский
Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8641 - 8660
Опубликована: Авг. 1, 2024
Osteosarcoma
is
the
predominant
primary
malignant
bone
tumor
that
poses
a
significant
global
health
challenge.
MicroRNAs
(miRNAs)
regulate
gene
expression
are
associated
with
osteosarcoma
pathogenesis.
Thus,
miRNAs
potential
therapeutic
targets
for
osteosarcoma.
Nanoparticles,
widely
used
targeted
drug
delivery,
facilitate
miRNA-based
treatment.
Numerous
studies
have
focused
on
miRNA
delivery
using
nanoparticles
to
inhibit
progress
of
Polymer-based,
lipid-based,
inorganic-based
and
extracellular
vesicles
were
deliver
treatment
They
can
be
modified
enhance
loading
capabilities.
Also,
was
combined
traditional
therapies,
example
chemotherapy,
treat
Consequently,
offers
promising
avenues
osteosarcoma,
providing
renewed
hope
patients.
This
review
emphasizes
utilizing
in
treatment,
then
introduced
summarized
detail.
And
it
also
discusses
prospects
clinical
applications.
Язык: Английский
Nanoparticle Accumulation and Penetration in 3D Tumor Models: the Effect of Size, Shape, and Surface Charge
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
Preclinical
studies
have
demonstrated
that
nanoparticles
(NPs)
hold
significant
potential
for
advancing
cancer
therapy
by
enhancing
therapeutic
efficacy
while
reducing
side
effects.
Their
effectiveness
in
solid
tumors
is,
however,
often
constrained
insufficient
accumulation
and
penetration.
Understanding
how
the
physicochemical
properties
of
NPs
–
such
as
size,
shape,
surface
charge
influence
their
interaction
with
cells
within
tumor
is
critical
optimizing
NP
design.
In
this
study,
we
addressed
challenge
inconsistent
behavior
systematically
evaluating
uptake
both
2D
3D
models,
penetration
spheroids.
Our
results
showed
larger
exhibited
higher
internalization
rates
models
but
limited
Furthermore,
negatively
charged
consistently
achieved
superior
deeper
than
neutral
positively
NPs.
Spherical
outperformed
rod-shaped
These
findings
underscore
importance
carefully
tailoring
to
complex
microenvironment
improved
outcomes
real
tumors.
Язык: Английский