Biometallic ions and derivatives: a new direction for cancer immunotherapy
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 15, 2025
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Язык: Английский
Albumin-based delivery systems: Recent advances, challenges, and opportunities
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 375 - 395
Опубликована: Фев. 9, 2025
Язык: Английский
Immunomodulatory metal-based biomaterials for cancer immunotherapy
Journal of Controlled Release,
Год журнала:
2024,
Номер
375, С. 249 - 268
Опубликована: Сен. 12, 2024
Язык: Английский
Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers
European Journal of Cancer,
Год журнала:
2024,
Номер
213, С. 115069 - 115069
Опубликована: Окт. 11, 2024
Язык: Английский
Conjugation of PDLA onto MgO Microspheres: Comparison between Solution Grafting and Melt Grafting Methods
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
MgO
microspheres
modified
by
solution
and
melt
grafting
methods
were
used
to
assess
the
effect
of
reaction
temperature
on
PDLA
graft
ratio,
resulting
in
varied
surface
morphologies
controllable
degradability
when
analyzed
kinetic
modeling.
Язык: Английский
Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140442 - 140442
Опубликована: Янв. 1, 2025
Язык: Английский
Mechanism and application prospect of magnesium-based materials in cancer treatment
Journal of Magnesium and Alloys,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Advances in cancer diagnosis and therapy by alginate-based multifunctional hydrogels: A review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
283, С. 137707 - 137707
Опубликована: Ноя. 18, 2024
Язык: Английский
A Stemness‐Enhanced Eye Drop Stimulates Corneal Regeneration via Sustained Release of Versican and Providing Lubricated Substrate
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Abstract
Stem
cells
are
vital
for
tissue
regeneration,
and
their
dysfunction
can
lead
to
diseases
like
aplastic
anemia
Alzheimer's
disease.
Limbal
epithelial
stem
(LESCs)
maintain
corneal
transparency
as
the
sole
source
of
epithelium.
Dysfunction
or
deficiency
LESCs
causes
opacity,
neovascularization
blindness,
known
limbal
cell
(LSCD).
Current
LSCD
treatment
mainly
relies
on
transplantation,
which
faces
challenges
limited
sources
immune
rejection,
making
therapy
challenging
often
ineffective.
This
study
introduces
a
cell‐free,
stemness‐enhanced
eye
drop
(SEED
@
)
stimulate
autologous
regeneration.
SEED
,
thermosensitive
Pluronic
F‐127
hydrogel
loaded
with
versican,
promote
proliferation,
chemotaxis,
migration
while
maintaining
stemness
via
Wnt/β‐catenin
signaling
pathway.
In
vivo,
alone
lubricate
cornea
repair
in
mouse
alkali
burn
model.
addition,
forms
thin,
transparent
layer
ocular
surface,
enabling
sustained
versican
release
up
24
h.
Notably,
twice‐daily
application
significantly
accelerated
regeneration
rabbit
model,
achieving
approximately
95%
by
day
14.
Collectively,
shows
great
potential
treating
offers
promising
drug
delivery
platform
diseases.
Язык: Английский