Applications of polymeric nanoparticles in drug delivery for glioblastoma
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Glioblastoma
(GBM)
remains
one
of
the
most
aggressive
and
treatment-resistant
brain
tumors,
necessitating
innovative
therapeutic
approaches.
Polymer-based
nanotechnology
has
emerged
as
a
promising
solution,
offering
precise
drug
delivery,
enhanced
blood-brain
barrier
(BBB)
penetration,
adaptability
to
tumor
microenvironment
(TME).
This
review
explores
diverse
applications
polymeric
nanoparticles
(NPs)
in
GBM
treatment,
including
delivery
chemotherapeutics,
targeted
therapeutics,
immunotherapeutics,
other
agents
for
radiosensitization
photodynamic
therapy.
Recent
advances
multifunctional
polymer
highlight
their
potential
overcome
challenges
that
brought,
such
heterogeneity
tumor,
BBB
limitation,
immunosuppressive
TME,
consideration
biocompatibility
safety.
Meanwhile,
future
directions
address
these
are
also
proposed.
By
addressing
obstacles,
polymer-based
represents
transformative
strategy
improving
treatment
outcomes,
paving
way
more
effective
patient-specific
therapies.
Язык: Английский
Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Bioorthogonal
catalysis
has
revolutionized
the
field
of
chemical
biology
by
enabling
selective
and
controlled
transformations
within
living
systems.
Research
converged
on
development
innovative
catalyst
scaffolds,
seeking
to
broaden
scope
bioorthogonal
reactions,
boost
their
efficiency,
surpass
limitations
conventional
catalysts.
This
review
provides
a
comprehensive
overview
latest
advancements
in
research
based
different
scaffold
materials.
Through
an
in-depth
analysis
fabrication
strategies
applications
catalysts,
this
discusses
design
principles,
mechanisms
action,
these
novel
catalysts
biology.
Current
challenges
future
directions
exploring
diversity
are
also
highlighted.
The
integration
diverse
scaffolds
offers
exciting
prospects
for
precise
manipulation
biomolecules
therapeutic
In
addition,
fills
gaps
previous
reviews,
such
as
fully
summarizing
presented
materials
applied
emphasizing
potential
impact
advancing
chemistry,
offering
field.
Язык: Английский
Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142798 - 142798
Опубликована: Апрель 1, 2025
Язык: Английский
Light-Triggered Bioorthogonal Nanozyme Hydrogels for Prodrug Activation and Treatment of Bacterial Biofilms
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Bioorthogonal
nanozymes
offer
in
situ
activation
of
pro-dyes
and
prodrugs
using
abiotic
chemical
transformations.
Bacterial
infections,
especially
biofilm-associated
are
extremely
difficult
to
treat
due
obstacles
such
as
poor
antibiotic
penetration
the
rising
threat
resistance.
Spatiotemporal
control
bioorthogonal
catalysis
provides
a
strategy
for
"on-demand"
generation
therapeutics,
effectively
localizing
therapeutic
action
minimizing
side
effects.
Here,
we
present
fabrication
visible-light-responsive
alginate
hydrogel
beads
embedded
with
polyzymes
(PZs).
Exposure
405
nm
light
induces
reduction
Fe(III)
Fe(II),
triggering
dissolution
PZ-gel
concomitant
release
polyzyme.
This
approach
enabled
selective
prodrug
Linezolid,
last-in-line
Gram-positive
bacterial
enabling
targeted
eradication
multidrug-resistantStaphylococcus
aureus
biofilms.
Overall,
use
biomaterial
along
noninvasive
visible
offers
nontoxic
platform
spatiotemporal
antibiotics
through
activation.
Язык: Английский
Injectable sodium alginate/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca2+-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
307, С. 141841 - 141841
Опубликована: Март 8, 2025
Язык: Английский