Improved wound care via novel dextran and boric acid loaded wound healing gel in excision mice wound model
Nosheen Maqbool,
Zakir Ali,
Sibgha Batool
и другие.
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106586 - 106586
Опубликована: Янв. 1, 2025
Язык: Английский
Fabrication of oral sustained release capecitabine loaded nanostructured lipid carriers with improved bioavailability and prolonged anticancer effects
Journal of Molecular Liquids,
Год журнала:
2025,
Номер
421, С. 126852 - 126852
Опубликована: Янв. 5, 2025
Язык: Английский
Development of Paroxetine Loaded Nanotransferosomal Gel for Intranasal Delivery with Enhanced Antidepressant Activity in Rats
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
246, С. 114351 - 114351
Опубликована: Ноя. 7, 2024
Язык: Английский
Physicochemical characterization and in vivo assessment of novel apixaban-loaded polymeric nano-aggregates
Journal of Pharmaceutical Investigation,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Язык: Английский
A thermoresponsive system of niclosamide for colon specific delivery in ulcerative colitis: Bioavailability and safety investigation
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106641 - 106641
Опубликована: Янв. 1, 2025
Язык: Английский
Improved biopharmaceutical performance of chlorpromazine-nanostructured lipid carriers: In vitro release, pharmacokinetics and toxicity testing
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106885 - 106885
Опубликована: Апрель 1, 2025
Язык: Английский
Comparative analysis of novel modified drug delivery systems for improving the oral bioavailability of water-insoluble tadalafil using copovidone, TPGS and hydroxypropyl-β-cyclodextrin
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
186, С. 118039 - 118039
Опубликована: Апрель 8, 2025
Язык: Английский
Thermoresponsive biomaterial system of Irinotecan and Curcumin for the treatment of colorectal cancer: In-vitro and in-vivo investigations
Aleena Maryiam,
Sibgha Batool,
Zakir Ali
и другие.
Pharmaceutical Development and Technology,
Год журнала:
2024,
Номер
30(1), С. 37 - 56
Опубликована: Дек. 27, 2024
This
study
aims
to
develop
a
thermoresponsive
biomaterial
system
of
irinotecan
(IRT)
and
curcumin
(CUR)
nano-transferosomal
gel
(IRT-CUR-NTG)
for
targeting
colorectal
cancer
(CRC).
The
IRT-CUR-NTs
were
statistically
optimized
loaded
into
poloxamer-based
thermosensitive
gel.
Transmission
electron
microscopy
(TEM),
Differential
scanning
calorimetry
(DSC)
Fourier-transform
infrared
spectroscopy
(FTIR)
the
performed,
whereas
pH,
gelation
time,
temperature,
mucoadhesive
strength
IRT-CUR-NTG
investigated.
In-vitro
release
anticancer
analyses
explored
using
HT29
cells.
Additionally,
in-vivo
pharmacokinetics
was
investigated
followed
by
histopathological
examination
analysis.
PS,
PDI,
ZP,
%EE
IRT
CUR
found
be
136.15
nm,
0.143,
-15.5
mV,
95.05%
85.12%,
respectively.
exhibited
spherical
shape
with
no
chemical
interactions
among
constituents.
Similarly,
homogenous
suitable
rectal
administration.
manifested
prolonged
profiles
CUR.
Moreover,
significantly
enhanced
(4-fold)
bioavailability
toxicity
observed
when
compared
conventional
more
effective
against
cell
lines.
In-vivo
antitumor
analysis
demonstrated
reduced
tumor
volume
mass
after
treatment
IRT-CUT-NTG,
indicating
improved
effect.
It
can
concluded
that
is
cancer.
Язык: Английский
Fabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib–Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management
Maha M. Ghalwash,
Amr Gamal,
Nada H. Mohammed
и другие.
Pharmaceuticals,
Год журнала:
2024,
Номер
18(1), С. 31 - 31
Опубликована: Дек. 30, 2024
Basal
cell
skin
cancer
(BCSC)
develops
when
cells
proliferate
uncontrollably.
Sonidegib
(SDB)
is
a
therapeutic
option
for
the
treatment
of
BCSC
by
inhibiting
hedgehog
signaling.
The
problems
with
SDB's
low
solubility,
poor
bioavailability,
resistance,
targeting,
and
first-pass
action
make
it
less
effective
taken
orally.
This
investigation
set
out
to
design
an
intratumoral
in
situ
pH-sensitive
hydrogel
SDB-invasomes
(IPHS-INV)
that
can
effectively
treat
improving
sustainability,
efficacy
while
also
reducing
its
resistance
undesirable
side
effects.
Numerous
S-INV
formulations
were
developed
using
Box-Behnken
Design
Expert
tested
before
settling
on
optimum
formulation.
An
experimental
7,
12-dimethylbenzanthracene
(DMBA)
carcinoma
rat
model
was
used
vivo
studies
IPHS-INV
formulation
after
combined
chitosan.
Phospholipids
(1.72%
w/w),
cholesterol
(0.15%
ethanol
(1%
v/v),
cineole
(1.5%
v/v)
shown
be
optimal
components
SDB-invasome
outperformed
permeation
bioavailability
free
SDB
7.14
6
times,
respectively,
sustained
release
57.41%.
showed
decrease
tumor
volume
99.05%
reduction
hypercellular
tumors,
indicating
anti-cancer
activity.
maintained
higher
concentration
targeting
These
findings
support
use
as
strategy
BCSC.
Язык: Английский