Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis
Journal of Controlled Release,
Год журнала:
2025,
Номер
380, С. 297 - 316
Опубликована: Фев. 7, 2025
Язык: Английский
The Gut Microbiota‐Xanthurenic Acid‐Aromatic Hydrocarbon Receptor Axis Mediates the Anticolitic Effects of Trilobatin
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
Current
treatments
for
ulcerative
colitis
(UC)
remain
limited,
highlighting
the
need
novel
therapeutic
strategies.
Trilobatin
(TLB),
a
naturally
derived
food
additive,
exhibits
potential
anti‐inflammatory
properties.
In
this
study,
dextran
sulfate
sodium
(DSS)‐induced
animal
model
is
used
to
investigate
effects
of
TLB
on
UC.
It
found
significantly
alleviates
DSS‐induced
UC
in
mice,
as
evidenced
by
reduction
disease
activity
index,
an
increase
colon
length,
improvement
histopathological
lesions.
Furthermore,
treatment
results
decrease
proinflammatory
cytokines
and
cytokines.
mitigates
modulating
intestinal
microbiota,
particularly
Akkermansia
,
which
enhances
tryptophan
metabolism
upregulates
production
xanthurenic
acid
(XANA).
To
confirm
role
TLB‐induced
microbiota
changes,
experiments
are
performed
with
pseudogerm‐free
mice
fecal
transplantation.
also
identified
XANA
key
metabolite
that
mediates
TLB's
protective
effects.
Both
markedly
activate
aromatic
hydrocarbon
receptor
(AhR).
Administration
AhR
antagonist
abrogates
their
effects,
thereby
confirming
involvement
underlying
mechanism.
conclusion,
study
reveals
mechanism
through
correcting
imbalances,
regulating
metabolism,
enhancing
production,
activating
AhR.
Язык: Английский
The therapeutic potential of nanoencapsulated anti-inflammatory drugs delivered to the gut
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 3
Опубликована: Фев. 5, 2025
Язык: Английский
Microbially synthesized nanomaterials: Advances and applications in biomedicine
Precision medicine and engineering.,
Год журнала:
2025,
Номер
unknown, С. 100019 - 100019
Опубликована: Фев. 1, 2025
Язык: Английский
Oral Antioxidant-Engineered Probiotics for the Treatment of Radiation-Induced Colitis
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Radiation
colitis
is
an
inflammatory
response
induced
by
damage
to
colonic
tissue
from
radiation
therapy
that
primarily
affects
patients
undergoing
abdominal
or
pelvic
treatments.
In
this
study,
we
designed
a
selenium-loaded
probiotic
(EcN-Se@SA)
encapsulated
in
sodium
alginate
gel
for
the
oral
treatment
of
colitis.
Selenium
nanoparticles
(Se
NPs)
exhibit
antioxidant,
anti-inflammatory,
ferroptosis,
and
repair-promoting
properties.
To
enhance
therapeutic
efficacy
Se
NPs
radiation-induced
colitis,
combined
with
Escherichia
coli
Nissle
1917
them
hydrogel.
The
resulting
EcN-Se@SA
formulation
not
only
withstands
gastric
acid
intestinal
fluids
but
also
remains
colon
cecum
extended
periods.
Oral
administration
attenuates
X-ray-induced
mice
through
its
antioxidant
anti-inflammatory
effects,
macrophage
reprogramming,
inhibition
ferroptosis
histiocytes.
This
work
introduces
promising
candidate
Язык: Английский
Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment
Theranostics,
Год журнала:
2025,
Номер
15(8), С. 3289 - 3315
Опубликована: Фев. 18, 2025
Inflammatory
bowel
disease
(IBD)
is
a
chronic
condition
affecting
the
intestines,
marked
by
immune-mediated
inflammation.
This
known
for
its
recurrent
nature
and
challenges
it
presents
in
treatment.
Recently,
probiotic
have
gained
attention
as
promising
alternative
to
traditional
small
molecular
drugs
monoclonal
antibody
chemotherapies
IBD.
Probiotic,
recognized
"living"
therapeutic
agent,
offers
targeted
treatment
with
minimal
side
effects
flexibility
biological
modifications,
making
them
highly
effective
IBD
management.
comprehensive
review
latest
advancements
engineering
probiotic-based
materials,
ranging
from
basic
mechanisms
modification
techniques
used
It
delves
deep
into
how
produces
intestinal
environment
discusses
various
strategies
enhance
probiotic's
efficacy,
including
genetic
modifications
formulation
improvements.
Additionally,
addresses
challenges,
practical
application
conditions,
future
research
directions
of
therapies
treatment,
providing
insights
their
feasibility
potential
clinical
implications.
Язык: Английский