Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164172 - 164172
Опубликована: Май 1, 2025
Язык: Английский
Materials & Design, Год журнала: 2025, Номер unknown, С. 113839 - 113839
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Myocardial infarction (MI) remains one of the leading causes mortality worldwide, necessitating advanced therapeutic strategies to address resulting electrical disconnection and pathological remodeling. This study developed a conductive hydrogel by covalently cross-linking silk fibroin hyaluronic acid, integrating MXene nanosheets mimic extracellular matrix (ECM). Results demonstrated that incorporation significantly enhanced hydrogel's conductivity, with SH-M5 exhibiting highest conductivity 0.32 S/m. The effectively improved signal transmission recovery left ventricular function in myocardial infarction. These findings underscore transformative role enhancing functional properties hydrogels for repair. unique capacity integrate mechanical reinforcement, biocompatibility, presenting promising platform treating advancing regenerative medicine.
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Abstract Myocardial infarction (MI) causes cardiac dysfunction and threatens global health. Timely reperfusion following MI unavoidably contributes to additional cardiomyocyte death, a phenomenon known as myocardial ischemia/reperfusion injury (I/RI). The surge in free radicals extensive loss significantly promote the progression toward heart failure, condition that remains major therapeutic challenge. Development of microRNA (miRNA)‐based therapeutics for I/RI is hindered by poor intracellular delivery miRNA its rapid degradation vivo. Nanozymes with enzyme‐mimetic activities offer promising platforms while concurrently mitigating oxidative stress. Hollow ceria nanozymes decorated gold nanoparticles (AuNPs) are developed deliver miR‐486, whose cavernous rooms enable them accommodate miRNA. Elevated miR‐486 expression shown suppress apoptosis alleviate I/RI. Equipped target peptide, miR‐486@CeO 2 /Au‐pep integrated superior enzyme‐mimicking functions than single entity, reactive oxygen species (ROS) scavenging, improved delivery. In mice, can specifically accumulate at escape from lysosomes, which further boosts bioactivity cardiomyocytes. These combined effects confer cardioprotection inhibit adverse ventricle remodeling. nanosystem through synergetic works provides an effective approach treating
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111339 - 111339
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 23, 2025
Postmyocardial infarction (MI), oxidative stress and insufficient blood supply contribute to impaired cardiac repair, while the subsequent formation of fibrotic scar tissue, characterized by poor electrical conductivity, further exacerbates dysfunction. Here, we compounded angiogenesis-promoting peptide (KRX) with effective pro-angiogenic effects conductive material carboxylated carbon nanotubes (CNTs) through electrostatic interaction, thus preparing CNT/KRX. Subsequently, prepared electroactive hydrogel (Gel@CK) compounding CNT/KRX natural polysaccharide hydrogel. This design endows both conductivity function promoting angiogenesis. In vitro, showed scavenging reactive oxygen species (ROS), cell compatibility, promoted endothelial MI model, significantly angiogenesis mitigated stress. Furthermore, it effectively shortened Q wave, R wave S (QRS) interval enhanced tissue integration. The indices measured echocardiography tests immunohistochemical analyses indicate that has improved reduced infarct size. composite demonstrates remarkable therapeutic potential for cardiovascular diseases dual modulation myocardial microenvironment activity.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164172 - 164172
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0