Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158616 - 158616
Опубликована: Дек. 1, 2024
Nano Letters, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.
Язык: Английский
Процитировано
3
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161177 - 161177
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 4, 2025
Chimeric antigen receptor (CAR) immune cell therapies have revolutionized oncology, particularly in hematological malignancies, yet their efficacy against solid tumors remains limited due to challenges such as dense stromal barriers and immunosuppressive microenvironments. With advancements nanobiotechnology, researchers developed various strategies methods enhance the CAR tumor treatment. In this Review, we first outline structure mechanism of CAR-T (T, T cell), CAR-NK (NK, natural killer), CAR-M (M, macrophage) deeply analyze potential these cells treatment they face. Next, explore how biomaterials can optimize treatments by improving microenvironment, controlling release, promoting infiltration, enhancing efficacy. Finally, summarize current solutions, emphasize effective combination therapy, look forward its future clinical application strategies. This Review provides important theoretical perspectives practical guidance for development more
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216557 - 216557
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Recent investigations have underscored the significant role of manganese ions (Mn2+) in immunization, particularly through activation cGAS-STING pathway, which enhances antitumor immune responses. However, rapid metabolism free Mn2+ following administration limits its effectiveness as an adjuvant. To address these challenges, microneedles (MNs) hyaluronic acid containing Sparfloxacin (SP) and zinc-manganese sulfide (ZMS) are prepared for postoperative situ treatment triple-negative breast cancer (TNBC) to prevent recurrence combat wound infection. ZMS/SP (ZS)-loaded MNs exhibit strong antimicrobial antibiofilm properties that crucial preventing infections. Moreover, generation reactive oxygen species by disrupts oxidative balance, effectively activating immunogenic cell death facilitating release cytokines. ZS significantly suppressed tumor growth, reduced lung metastasis, promoted healing. These effects accompanied notable increases infiltration activation, is consistent with gene sequencing results. Activation pathway further improved immunity. findings highlight potential effective safe utilizes immunostimulatory enhance local systemic responses prevention TNBC metastasis.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 13, 2025
Abstract Analyzing the relationship between tumor O 2 microenvironment (TOME) and immune during radiotherapy regulating it will provide new insights into combination of immunotherapy. In experiments, is observed that exacerbation hypoxia after activated HIF pathway, which, in turn, led to T‐cell exhaustion by upregulating PD‐L1 expression promoting infiltration MDSCs. To address this, a manganese ion‐doped Au–Pt nanozyme‐coated modulator (Mn‐Nz‐M) designed prepared reengineer TOME. First, high catalase activity Mn‐Nz‐M efficiently generated at tumor‐site, modulating TOME improving efficacy. More importantly, studies vitro vivo showed Mn‐Nz‐M‐mediated improvement can reverse PD‐1 + T cell post activate function. Additionally, Mn 2+ released from simultaneously amplify cGAS‐STING pathway NK cells for anti‐tumor activity. This reengineering strategy radio‐immunotherapy not only eliminates primary solid tumors but also inhibits metastasis, providing potential therapeutic targets enhancing interaction
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2024, Номер unknown, С. 217350 - 217350
Опубликована: Ноя. 1, 2024
Pancreatic cancer remains one of the most challenging malignancies to treat due its late-stage diagnosis, aggressive progression, and high resistance existing therapies. This review examines latest advancements in early detection, therapeutic strategies, with a focus on emerging biomarkers, tumor microenvironment (TME) modulation, integration artificial intelligence (AI) data analysis. We highlight promising including microRNAs (miRNAs) circulating DNA (ctDNA), that offer enhanced sensitivity specificity for early-stage diagnosis when combined multi-omics panels. A detailed analysis TME reveals how components such as cancer-associated fibroblasts (CAFs), immune cells, extracellular matrix (ECM) contribute therapy by creating immunosuppressive barriers. also discuss interventions target these components, aiming improve drug delivery overcome evasion. Furthermore, AI-driven analyses are explored their potential interpret complex data, enabling personalized treatment strategies real-time monitoring response. conclude identifying key areas future research, clinical validation regulatory frameworks AI applications, equitable access innovative comprehensive approach underscores need integrated, outcomes pancreatic cancer.
Язык: Английский
Процитировано
2
Chemical Biology & Drug Design, Год журнала: 2024, Номер 104(6)
Опубликована: Дек. 1, 2024
ABSTRACT Non‐small‐cell lung cancer (NSCLC) stands as a primary contributor to cancer‐related deaths worldwide. It has been demonstrated that Lycorine (LYD), naturally occurring active sesquiterpene present in Chinese medicinal plants, exhibits anti‐cancer properties across various cell lines. However, the underlying mechanisms of LYD‐induced anti‐tumor NSCLC are not fully known. This study LYD significantly reduced proliferation and induced apoptosis by increasing intracellular ROS levels. The inhibition using N‐acetylcysteine (NAC) eliminated effects LYD, resulting increased viability. Additionally, treatment activated STING pathway expression CXCL10, CXCL9 CCL5 cells. Mechanistically, was found reduce protein levels P70S6K S6K, which key proteins involved growth survival. Notably, vivo experiments inhibited H358 xenograft LLC1 tumor, exhibiting activity elevating CD8 + T cells mouse model. Our findings suggest possesses potent inducing through generation modulating chemokines. Furthermore, also exerts its antitumor inhibiting crucial growth. Overall, shows promise potential therapeutic agent for treatment.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158616 - 158616
Опубликована: Дек. 1, 2024
Процитировано
0