Biodegradable Polymers for Application as Robust Immunomodulatory Biomaterial Carrier Systems

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

Abstract The field of immunotherapeutics is rapidly evolving with the advent cell therapies, complex biologics, and a host other compounds. Polymeric carriers are often used to tune safety efficacy profiles these novel drugs. Despite their prevalence in pre‐clinical clinical applications, non‐degradable materials present delivery challenges including diffusion‐limited release, frustrated phagocytosis, limited clearance. In contrast, biodegradable polymeric systems provide safer alternative addition displaying advantageous properties for immunotherapies. this review, discussion polymers poly(lactic‐co‐glycolic acid) (PLGA), poly(beta‐amino esters) (PBAEs), acetalated dextran (Ace‐DEX), chitosan, alginate, hyaluronic acid (HA) as immunomodulatory biomaterial suggest that variety can be generate tailored formulations different therapeutic payloads disease indications. These carrier enhance immunotherapies via tunable degradation rates, enhanced antigen‐presentation, inherent biomaterials, among mechanisms. Polymers formulated applications synthetic, semi‐synthetic, or naturally derived. Therefore, it crucial consider environmental impact polymer sources, particle fabrication methods, solvent usage sustainably develop effective therapies field.

Язык: Английский

Application of in-silico approaches in subunit vaccines: Overcoming the challenges of antigen and adjuvant development

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113629 - 113629

Опубликована: Март 1, 2025

Язык: Английский