RSC Advances, Год журнала: 2025, Номер 15(22), С. 17255 - 17265
Опубликована: Янв. 1, 2025
The CDDP@PPy@Fe 3 O 4 nanoplatform delivers cisplatin via magnetic targeting (reducing systemic toxicity) and enables NIR-triggered photothermal conversion for synergistic chemo-photothermal therapy against OSCC.
Язык: Английский
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 288, С. 117427 - 117427
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
4
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Synergistic photodynamic/photothermal therapy (PDT/PTT) can be used to target cancer cells by locally generating singlet oxygen species or increasing temperature under laser irradiation. This approach offers higher tumor ablation efficiency, lower therapeutic dose requirements, and reduced side effects compared single treatment approaches. However, the efficiency of PDT/PTT is still limited low levels within solid tumors caused abnormal vasculature altered cell metabolism. To address these challenges, we developed multifunctional nanoparticles with high catalytic activity for converting hydrogen peroxide (H2O2) into (O2). Using poly(styrene-co-maleic anhydride) (PSMA) as a cross-linker, generated compact, highly fluorescent Pdots, poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b']dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT) near-infrared photosensitizer both photodynamic photothermal applications, incorporated manganese (Mn) ions catalyze H2O2-to-O2 conversion. These Mn-doped Pdots significantly enhance O2 production, achieving an enhanced 1O2 quantum yield from 0.46 0.64 addition H2O2, goal improving PDT efficiency. With this rational design, produced H2O2-to-1O2 ability potential use in PDT. For our generate conversion 53%. In vitro studies using human MCF7 adenocarcinoma confirmed biocompatibility absence exposure pronounced killing effect irradiation synergistic PDT/PTT. results highlight promise overcoming limitations, balancing performance PDT/PTT, enhancing efficacy vitro.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
Breast cancer utilizes diverse immunosuppressive mechanisms to evade immune surveillance, thereby impairing immunotherapeutic effects. In this work, a chimeric peptide functionalized immunostimulant (designated as aGlyR) is fabricated boost photodynamic immunotherapy through PD-L1 deglycosylation and CD47 inhibition. The photosensitizer protoporphyrin IX (PpIX) conjugated via hydrophilic PEG8 linker, yielding the Fmoc-K(PpIX)-PEG8-GFTATPPAPDSPQEP. This could self-assemble into nanomicelles capable of encapsulating inhibitor RRx-001, generating multifunctional aGlyR. vitro in vivo results indicate that therapy (PDT) aGlyR disrupt breast cells trigger immunogenic cell death (ICD), leading release tumor-associated antigens (TAAs) activation immunological cascades. Additionally, component degradation PD-L1, which restores T cell-mediated activity. Concurrently, RRx-001 blocks pathway, disrupting antiphagocytic signaling activating innate responses. synergistic immunomodulatory approach effectively reverses complex factors, significantly enhancing effects conventional treatments.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
We have developed self-assembled nanoparticles (BODIPY 4 -PEG NPs) that exhibit excellent imaging performance and photothermal conversion efficiency.
Язык: Английский
Процитировано
0
Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(5)
Опубликована: Апрель 8, 2025
ABSTRACT Generally, single cancer treatment is insufficient to achieve ideal therapeutic effect. Multimodal therapy has the potential overcome efficacy challenges and reveals great promise in enhancing Herein, a combination system (DOX@Fe‐PBC) based on chemotherapy, chemodynamic (CDT), ferroptosis was constructed by loading anticancer drug doxorubicin hydrochloride (DOX) into Fe‐based metal–organic framework (Fe‐PBC). In simulated tumor microenvironment, released DOX be DNA intercalator topoisomerase II inhibitor realize chemotherapy (CT) iron ions were delivered induce Fenton reaction, which boost generation of •OH, resulting enhancement effect (CDT). Meantime, could consume glutathione (GSH) reduce expression peroxidase 4 (GPX4); then, lipid peroxides (LPO) accumulated ferroptosis. DOX@Fe‐PBC provided an effective strategy CDT, treatment.
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 694, С. 137688 - 137688
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216781 - 216781
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0
Nanoscale Horizons, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Schematic of the action mechanism Pira–Gem co-loaded mPEG- b -PLA-LA nanoparticles on a cancer cell.
Язык: Английский
Процитировано
0
RSC Advances, Год журнала: 2025, Номер 15(22), С. 17255 - 17265
Опубликована: Янв. 1, 2025
The CDDP@PPy@Fe 3 O 4 nanoplatform delivers cisplatin via magnetic targeting (reducing systemic toxicity) and enables NIR-triggered photothermal conversion for synergistic chemo-photothermal therapy against OSCC.
Язык: Английский
Процитировано
0