Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 715 - 736

Опубликована: Янв. 31, 2025

Major depressive disorder (MDD) is a global health concern. Studies have demonstrated that oleanolic acid (OA) has regulatory effect on MDD. However, OA poorly soluble, low oral bioavailability, and faces challenges in crossing the blood-brain barrier. In this study, building upon previous formulation of cubic liquid crystal nanoparticles (OA-LCNP), we combined with thermosensitive gel for nasal administration investigated pharmacological effects OA-LCNP (OANG) depression. This study aimed to evaluate OANG depression symptoms rats. was prepared using Poloxamer F127 F68 as matrix, ratios were investigated. The pharmacokinetics studied rats, content determined chromatography-mass spectrometry (LC-MS). evaluated chronic unpredictable mild stress (CUMS) model phase transition temperature 34°C, release from slow according Higuchi kinetic equation. AUC0-t brain tissue after 1.21 times observed intravenous administration. Additionally, brain-targeting efficiency nasal-brain direct transfer 29.91% 9.44% higher, respectively, than those administration, indicating capability delivery system. Network analysis revealed anti-depressant may be linked neuroactive ligand-receptor interactions, PPAR signaling pathway, efferocytosis pathways. Experimental results CUMS rats showed significantly affected interleukin (IL)-4, IL-6, acetylcholinesterase, acetylcholine, 5-hydroxytryptamine, brain-derived neurotrophic factor, improved depression-like behavior measured by sucrose preference, forced swimming, box shuttle tests. drug system specific properties exerts effects.

Язык: Английский

Nir Light Triggering Photosensitive Pda/Sa Hydrogel to Control Ibuprofen Release

Опубликована: Янв. 1, 2025

Язык: Английский

Pitaya stem polysaccharide promotes wound healing by modulating macrophage polarization via single-cell RNA sequencing evidence

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142653 - 142653

Опубликована: Март 1, 2025

Язык: Английский