Robust Injectable Hydrogels for Hemophilic Arthropathy via Anti‐Inflammation, Iron Removal and Cartilage Protection DOI
Jianhua Zhang,

Jian Zhong,

Bo Liang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract Hemophilic arthropathy (HA), a form of arthritis associated with joint bleeding, presents extra challenges in treatment due to intermittent bleeding‐induced iron‐overloading, oxidative stress, and inflammation. Conventional therapeutic approaches have predominantly concentrated on achieving hemostasis reducing inflammation, yet they fallen short effectively managing iron overload safeguarding cartilage, resulting less‐than‐ideal outcomes. To address these issues, series injectable hydrogels is facilely fabricated via one‐step assembly polyphenols, chelators, lipoic acid. In vitro investigations demonstrate that the not only good performances antioxidation anti‐inflammation, but also exhibit promising prospects removal, adhesion resistance, wear resistance. Moreover, vivo studies are further carried out indicate diminished inflammatory response, ameliorative iron‐overload‐related lesion indicators, cartilage preservation. This class robust multifunctional composed clinically available drugs along commonly used commercial ingredients would offer new opportunities toward efficient HA.

Язык: Английский

Platelet-rich plasma-derived exosomes have the novel ability to alleviate insertional Achilles tendinopathy by promoting tenogenesis in tendon stem/progenitor cells DOI Creative Commons

A Zhang,

Qing Xie,

Shixiang Guo

и другие.

Biomaterials Advances, Год журнала: 2025, Номер 173, С. 214272 - 214272

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
Robust Injectable Hydrogels for Hemophilic Arthropathy via Anti‐Inflammation, Iron Removal and Cartilage Protection DOI
Jianhua Zhang,

Jian Zhong,

Bo Liang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract Hemophilic arthropathy (HA), a form of arthritis associated with joint bleeding, presents extra challenges in treatment due to intermittent bleeding‐induced iron‐overloading, oxidative stress, and inflammation. Conventional therapeutic approaches have predominantly concentrated on achieving hemostasis reducing inflammation, yet they fallen short effectively managing iron overload safeguarding cartilage, resulting less‐than‐ideal outcomes. To address these issues, series injectable hydrogels is facilely fabricated via one‐step assembly polyphenols, chelators, lipoic acid. In vitro investigations demonstrate that the not only good performances antioxidation anti‐inflammation, but also exhibit promising prospects removal, adhesion resistance, wear resistance. Moreover, vivo studies are further carried out indicate diminished inflammatory response, ameliorative iron‐overload‐related lesion indicators, cartilage preservation. This class robust multifunctional composed clinically available drugs along commonly used commercial ingredients would offer new opportunities toward efficient HA.

Язык: Английский

Процитировано

0