Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy DOI Open Access
Qi Sun, Mengling Liu,

Hetian Ren

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid‐induced TNF receptor (GITR) and sensitivity to reactive oxygen species (ROS). This study develops a near‐infrared (NIR)‐responsive hollow nanocomplex (HPDA‐OPC/DTA‐1) using polydopamine nanoparticles (HPDA), endowed with thermogenic antioxidative properties, specifically targeting Tregs activate antitumor immunity. The GITR agonist DTA‐1, combined antioxidant oligomeric proanthocyanidins (OPC) deplete Tregs. However, depletion alone may not sufficiently trigger robust immune responses. HPDA nanocarrier enhances capacities, supporting photothermal immunotherapy. HPDA‐OPC/DTA‐1 demonstrates NIR responsiveness for both therapy (PTT) OPC release, while facilitating via DTA‐1 reducing ROS levels, thereby reviving Notably, intratumoral CD4 + CD25 FOXP3 exhibited 4.08‐fold reduction alongside 49.11‐fold increase in CD8 cells/Tregs relative controls. Enhanced dendritic (DCs) maturation immunogenic cell death (ICD) induction further demonstrate that alleviates immunosuppression activates Ultimately, observed inhibitory effect (tumor volume: 6.75‐fold versus control) an over 80% survival rate highlight therapeutic potential combining targeting, strategy, immunotherapy effective cancer treatment.

Язык: Английский

Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy DOI Open Access
Qi Sun, Mengling Liu,

Hetian Ren

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Abstract In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid‐induced TNF receptor (GITR) and sensitivity to reactive oxygen species (ROS). This study develops a near‐infrared (NIR)‐responsive hollow nanocomplex (HPDA‐OPC/DTA‐1) using polydopamine nanoparticles (HPDA), endowed with thermogenic antioxidative properties, specifically targeting Tregs activate antitumor immunity. The GITR agonist DTA‐1, combined antioxidant oligomeric proanthocyanidins (OPC) deplete Tregs. However, depletion alone may not sufficiently trigger robust immune responses. HPDA nanocarrier enhances capacities, supporting photothermal immunotherapy. HPDA‐OPC/DTA‐1 demonstrates NIR responsiveness for both therapy (PTT) OPC release, while facilitating via DTA‐1 reducing ROS levels, thereby reviving Notably, intratumoral CD4 + CD25 FOXP3 exhibited 4.08‐fold reduction alongside 49.11‐fold increase in CD8 cells/Tregs relative controls. Enhanced dendritic (DCs) maturation immunogenic cell death (ICD) induction further demonstrate that alleviates immunosuppression activates Ultimately, observed inhibitory effect (tumor volume: 6.75‐fold versus control) an over 80% survival rate highlight therapeutic potential combining targeting, strategy, immunotherapy effective cancer treatment.

Язык: Английский

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