Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer DOI
Xing Li, Kun Yuan, Yisheng Yin

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local drug delivery systems based on nanomaterials offer promising strategies address issue by modifying release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with chemotherapy. In study, we utilized electrospun nanofibrous mats loaded docetaxel for sustained delivery. vitro experiments demonstrated that these implantable drug-loaded effectively inhibited prostate cancer cell growth, induced cycle arrest, promoted apoptosis. animal models, exhibited prominent therapeutic positive postoperatively. Importantly, docetaxel-loaded modulated immune microenvironment suppressing M2-like macrophages, increasing ratio between M1- CD8+ T-cell infiltration. Local administration reduced toxicity compared summary, developed an mat localized delivery, which offers a prospective strategy managing after surgery.

Язык: Английский

Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer DOI
Xing Li, Kun Yuan, Yisheng Yin

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local drug delivery systems based on nanomaterials offer promising strategies address issue by modifying release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with chemotherapy. In study, we utilized electrospun nanofibrous mats loaded docetaxel for sustained delivery. vitro experiments demonstrated that these implantable drug-loaded effectively inhibited prostate cancer cell growth, induced cycle arrest, promoted apoptosis. animal models, exhibited prominent therapeutic positive postoperatively. Importantly, docetaxel-loaded modulated immune microenvironment suppressing M2-like macrophages, increasing ratio between M1- CD8+ T-cell infiltration. Local administration reduced toxicity compared summary, developed an mat localized delivery, which offers a prospective strategy managing after surgery.

Язык: Английский

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